Rho GTPases are involved in the regulation of NF-κB by genotoxic stress

Experimental Cell Research

Volumn 264, Issue 2, 2001, Pages 244-249

  Gnad, Renate ^a   Kaina, Bernd ^a   Fritz, Gerhard ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

HMG CoA reductase inhibitor; NF B; Rho GTPases; Stress signaling

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN B; DOXORUBICIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEVINOLIN; RHO FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; DNA BINDING; GENE EXPRESSION; GENOTOXICITY; HELA CELL; HUMAN; HUMAN CELL; ISOPRENYLATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FAMILY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

EID: 0035298097     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5165     Document Type: Article

References (31)

1. The NF-kB and IkB proteins: New discoveries and insights
2. Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C
3. An essential role for NF-kB in preventing TNF-a-induced cell death
4. Suppression of TNF-a-induced apoptosis by NF-kB
5. TNF and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kB
6. Sequential DNA damage-independent and -dependent activation of NF-kB by UV
7. Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms
8. Three paths to stress relief
9. Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases
10. Activation of the nuclear factor kappaB by Rho, Cdc42 and Rac1 proteins
11. Activation of the small GTPase Cdc42 by inflammatory cytokines TNF(alpha) and IL-1 and by the Epstein-Barr virus transforming protein LMP1
12. Protein prenylation: More than just glue?
13. Prenyl proteins in eukaryotic cells: A new type of membrane anchor
14. Regulation of the mevalonate pathway
15. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
16. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
17. Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors
18. Statins for prevention of stroke
19. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
20. Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton
21. The mutant plasmacytoma cell line S107 allows the identification of distinct pathways leading to NF-kB activation
22. Heterodimer formation of c-Jun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein
23. IkappaBα degradation and nuclear factor-κB DNA binding are insufficient for interleukin-1B and tumor necrosis factor α-induced κB-dependent transcription
24. Lovastatin-mediated G1 arrest through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase
25. Glucosylation of Rho proteins by Clostridium difficile toxin B
26. The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins
27. NF-kappaB activation by tumor necrosis factor requires the Akt serine-threonine kinase
28. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
29. HMG-CoA reductase inhibition: Anti-inflammatory effects beyond lipid lowering
30. Pravastatin: An antithrombotic effect independent of the cholesterol-lowering effect
31. Suppression of TNF-alpha-induced apoptosis by NF-kappaB