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Guarantor of the article: Björn Moum, M.D., Ph.D. Specific author contributions: All of the authors of this paper have contributed in planning of the study and writing of the manuscript. With the exception of Geir Aamodt, all of the authors have also participated in the collection of the data. Financial support: This study has been financially supported by the European Community (Grant QLG4-CT-200-01414). The work was also supported by a research fellowship grant from the Department of Medical Research, Sörlandet Hospital, Norway. Potential competing interests: None.
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