Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats

Neurochemistry International

Volumn 54, Issue 5-6, 2009, Pages 363-371

  Kanemaru, Kazuya ^a   Nishi, Kyoko ^a   Hasegawa, Shu ^a   Diksic, Mirko ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Antidepressant treatment; Autoradiography; Depression model; Tracer study

Indexed keywords

CITALOPRAM; SEROTONIN; SODIUM CHLORIDE; TRYPTOPHAN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DEPRESSION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RADIOGRAPHY; RAT; SEROTONINERGIC SYSTEM; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CITALOPRAM; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DRUG RESISTANCE; GENETIC PREDISPOSITION TO DISEASE; RAPHE NUCLEI; RATS; RATS, INBRED STRAINS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SPECIES SPECIFICITY; UP-REGULATION;

ANIMALIA; RATTUS;

EID: 61449173676     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.01.005     Document Type: Article

References (81)

1. Auerbach S.B., and Hjorth S. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn Schmiedebergs Arch. Pharmacol. 352 (1995) 597-606
2. Baxter Jr. L.R., Schwartz J.M., Phelps M.E., Mazziotta J.C., Guze B.H., Selin C.E., Gerner R.H., and Sumida R.M. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch. Gen. Psychiatry 46 (1989) 243-250
3. 11C]methyl-l-tryptophan PET study. Neurochem. Int. 52 4-5 (2008) 701-708
4. Blier P., de Montigny C., and Chaput Y. A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence. J. Clin. Psychiatry 51 Suppl. (1990) 14-20 (discussion 21, review)
5. 1A agonists and selective 5-HT reuptake inhibitors on the 5-HT system. Neuropsychopharmacology 15 2 (1996) 213-216
6. Bloxam D.L., and Curzon G. A study of proposed determinants of brain tryptophan concentration in rats after portocaval anastomosis or sham operation. J. Neurochem. 31 5 (1978) 1255-1263
7. Bosker F.J., Klompmakers A.A., and Westenberg H.G. Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat. Neuropharmacology 34 5 (1995) 501-508
8. Bremner J.D., Innis R.B., Salomon R.M., Staib L.H., Ng C.K., Miller H.L., Bronen R.A., Krystal J.H., Duncan J., Rich D., Price L.H., Malison R., Dey H., Soufer R., and Charney D.S. Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Arch. Gen. Psychiatry 54 (1997) 364-374
9. Breuer M.E., Groenink L., Oosting R.S., Westenberg H.G., and Olivier B. Long-term behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats. Biol. Psychiatry 61 8 (2007) 990-995
10. 1A receptors. Br. J. Pharmacol. 142 3 (2004) 469-478
11. Cryan J.F., Page M.E., and Lucki I. Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test. Eur. J. Pharmacol. 436 3 (2002) 197-205
12. Cryan J.F., and Mombereau C. In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol. Psychiatry 9 4 (2004) 326-357
13. Dilsaver S.C. Cholinergic mechanisms in depression. Brain Res. 396 3 (1986) 285-316
14. Dobson C.F., Tohyama Y., Diksic M., and Hamel E. Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain. Cephalalgia 24 1 (2004) 2-11
15. Dremencov E., Newman M.E., Kinor N., Blatman-Jan G., Schindler C.J., Overstreet D.H., and Yadid G. Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment. Neuropharmacology 48 1 (2005) 34-42
16. El Khoury A., Gruber S.H., Mørk A., and Mathé A.A. Adult life behavioral consequences of early maternal separation are alleviated by escitalopram treatment in a rat model of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 30 3 (2006) 535-540
17. Garattini S., and Samanin R. Biochemical hypotheses on antidepressant drugs: a guide for clinicians or a toy for pharmacologists?. Psychol. Med. 18 2 (1988) 287-304
18. Geyer M.A., Petersen L.R., Rose G.J., Horwitt D.D., Light R.K., Adams L.M., Zook J.A., Hawkins R.L., and Mandell A.J. The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: tactile startle. J. Pharmacol. Exp. Ther. 207 3 (1978) 837-847
19. Goodwin G.M. How do antidepressants affect serotonin receptors? The role of serotonin receptors in the therapeutic and side effect profile of the SSRIs. J. Clin. Psychiatry 57 Suppl. 4 (1996) 9-13
20. Grubbs F. Procedures for detecting outlying observations in samples. Technometrics 11 1 (1969) 1-21
21. +-enriched medium. J. Neurochem. 33 5 (1979) 1031-1042
22. Hasegawa S., Nishi K., Watanabe A., Overstreet D.H., and Diksic M. Brain 5-HT synthesis in the flinders sensitive line rat model of depression: an autoradiographic study. Neurochem. Int. 48 5 (2006) 358-366
23. Hasegawa S., Watanabe A., Nguyen K.Q., Debonnel G., and Diksic M. Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study. Psychopharmacology (Berlin) 179 4 (2005) 781-790
24. Heim C., and Nemeroff C.B. The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. Biol. Psychiatry 46 11 (1999) 1509-1522
25. Hiemke C., and Härtter S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol. Ther. 85 1 (2000) 11-28
26. Hyttel J. Neurochemical characterization of a new potent and selective serotonin uptake inhibitor: Lu 10-171. Psychopharmacology (Berlin) 51 3 (1977) 225-233
27. Invernizzi R., Belli S., and Samanin R. Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Res. 584 1-2 (1992) 322-324
28. Janowsky D.S., and Risch S.C. Cholinomimetic and anticholinergic drugs used to investigate an acetylcholine hypothesis of affective disorders and stress. Drug Dev. Res. 4 (1984) 125-142
29. Janowsky D.S., Overstreet D.H., and Nurnberger Jr. J.I. Is cholinergic sensitivity a genetic marker for the affective disorders?. Am. J. Med. Genet. 54 4 (1994) 335-344
30. Jeltsch-David H., Koenig J., and Cassel J.C. Modulation of cholinergic functions by serotonin and possible implications in memory: general data and focus on 5-HT(1A) receptors of the medial septum. Behav. Brain Res. 195 1 (2008) 86-97
31. Kanemaru K., Hasegawa S., Nishi K., and Diksic M. Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats: an autoradiographic evaluation. Brain Res. Bull. 77 (2008) 214-220
32. Kelly J.P., Wrynn A.S., and Leonard B.E. The olfactory bulbectomized rat as a model of depression: an update. Pharmacol. Ther. 74 3 (1997) 299-316
33. Kiss J.P. Theory of active antidepressants: a nonsynaptic approach to the treatment of depression. Neurochem. Int. 52 1-2 (2008) 34-39
34. 11C]methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. Eur. Neuropsychopharmacol. 16 3 (2006) 220-223
35. 1A receptors. J. Pharmacol. Exp. Ther. 282 3 (1997) 1581-1590
36. Liu S., Wen S.W., McMillan D., Trouton K., Fowler D., and McCourt C. Increased neonatal readmission rate associated with decreased length of hospital stay at birth in Canada. Can. J. Public Health 91 1 (2000) 46-50
37. Mayberg H.S. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br. Med. Bull. 65 (2003) 193-207
38. Mayberg H.S., Brannan S.K., Tekell J.L., Silva J.A., Mahurin R.K., McGinnis S., and Jerabek P.A. Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol. Psychiatry 48 8 (2000) 830-843
39. Milne R.J., and Goa K.L. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs 41 3 (1991) 450-477
40. Mück-Seler D., Jevric-Causevic A., and Diksic M. Influence of fluoxetine on regional serotonin synthesis in the rat brain. J. Neurochem. 67 6 (1996) 2434-2442
41. Muraki I., Inoue T., Hashimoto S., Izumi T., Ito K., and Koyama T. Effect of subchronic lithium treatment on citalopram-induced increases in extracellular concentrations of serotonin in the medial prefrontal cortex. J. Neurochem. 76 2 (2001) 490-497
42. 1B/1D receptor antagonist GR 127,935 on anxiolytic effect of citalopram in conditioned fear stress in the rat. Eur. J. Pharmacol. 586 1-3 (2008) 171-178
43. Nagahiro S., Takada A., Diksic M., Sourkes T.L., Missala K., and Yamamoto Y.L. A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats. J. Cereb. Blood Flow Metab. 10 1 (1990) 13-21
44. Nelson N. Presynaptic events involved in neurotransmission. J. Physiol. Paris 87 3 (1993) 171-178
45. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., and Monteggia L.M. Neurobiology of depression. Neuron 34 (2002) 13-25
46. 1B receptors, compared to control rats. Neurochem. Int. 54 5-6 (2008) 299-307
47. Nishizawa S., Benkelfat C., Young S.N., Leyton M., Mzengeza S., de Montigny C., Blier P., and Diksic M. Differences between males and females in rates of serotonin synthesis in human brain. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 5308-5313
48. O'Neil M.F., and Moore N.A. Animal models of depression: are there any?. Hum. Psychopharmacol. 18 4 (2003) 239-254
49. Okazawa H., Yamane F., Blier P., and Diksic M. Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain. J. Neurochem. 72 (1999) 2022-2031
50. Overstreet D.H. Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists. Behav. Genet. 32 5 (2002) 335-348
51. Overstreet D.H., Keeney A., and Hogg S. Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression. Eur. J. Pharmacol. 492 2-3 (2004) 195-201
52. Overstreet D.H., Daws L.C., Schiller G.D., Orbach J., and Janowsky D.S. Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression. Pharmacol. Biochem. Behav. 59 4 (1998) 777-785
53. Overstreet D.H., Russell R.W., Helps S.C., and Messenger M. Selective breeding for sensitivity to the anticholinesterase DFP. Psychopharmacology (Berlin) 65 1 (1979) 15-20
54. Overstreet D.H., Friedman E., Mathé A.A., and Yadid G. The flinders sensitive line rat: a selectively bred putative animal model of depression. Neurosci. Biobehav. Rev. 29 4-5 (2005) 739-759
55. Papp M., Nalepa I., Antkiewicz-Michaluk L., and Sánchez C. Behavioural and biochemical studies of citalopram and WAY 100635 in rat chronic mild stress model. Pharmacol. Biochem. Behav. 72 1-2 (2002) 465-474
56. Paxinos G., and Watson C. The Rat Brain Atlas in Stereotaxic Coordinates. Compact third edition (1997), Academic Press, New York
57. Perreau-Linck E., Beauregard M., Gravel P., Paquette V., Soucy J.P., Diksic M., and Benkelfat C. In vivo measurements of brain trapping of C-labelled α-methyl-l-tryptophan during acute changes in mood states. J. Psychiatry Neurosci. 32 6 (2007) 430-434
58. Petersén A., Wörtwein G., Gruber S.H., and Mathé A.A. Escitalopram reduces increased hippocampal cytogenesis in a genetic rat depression model. Neurosci. Lett. 436 (2008) 305-308
59. Plaznik A., Kostowski W., and Archer T. Serotonin and depression: old problems and new data. Prog. Neuropsychopharmacol. Biol. Psychiatry 13 5 (1989) 623-633
60. Raap D.K., and Van de Kar L.D. Selective serotonin reuptake inhibitors and neuroendocrine function. Life Sci. 65 12 (1999) 1217-1235
61. 11C]methyl-l-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Arch. Gen. Psychiatry 61 6 (2004) 556-563
62. 1B-receptor knockout mice. Brain Res. Bull. 70 1 (2006) 81-93
63. Russell R.W., Overstreet D.H., Messenger M., and Helps S.C. Selective breeding for sensitivity to DFP: generalization of effects beyond criterion variables. Pharmacol. Biochem. Behav. 17 5 (1982) 885-891
64. Rygula R., Abumaria N., Flügge G., Hiemke C., Fuchs E., Rüther E., and Havemann-Reinecke U. Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats. Behav. Pharmacol. 17 1 (2006) 19-29
65. Salomon R.M., Miller H.L., Delgado P.L., and Charney D. The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders. Int. Clin. Psychopharmacol. 8 Suppl. 2 (1993) 41-46
66. Sánchez C., Gruca P., Bien E., and Papp M. R-citalopram counteracts the effect of escitalopram in a rat conditioned fear stress model of anxiety. Pharmacol. Biochem. Behav. 75 4 (2003) 903-907
67. Sapolsky R.M., and Meaney M.J. Maturation of the adrenocortical stress response: neuroendocrine control mechanisms and the stress hyporesponsive period. Brain Res. 396 1 (1986) 64-76
68. 1A binding sites. Brain Res. Bull. 75 5 (2008) 545-555
69. Shayit M., Yadid G., Overstreet D.H., and Weller A. 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression. Brain Res. 980 1 (2003) 100-108
70. Slattery D.A., Hudson A.L., and Nutt D.J. Invited review: the evolution of antidepressant mechanisms. Fundam. Clin. Pharmacol. 18 1 (2004) 1-21
71. Soares J.C., and Mann J.J. The functional neuroanatomy of mood disorders. J. Psychiatric Res. 31 (1997) 393-432
72. 14C]methyl-l-tryptophan. Eur. Neuropsychopharmacol. 11 3 (2001) 193-202
73. Tohyama Y., Yamane F., Fikre Merid M., Blier P., and Diksic M. Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study. J. Neurochem. 80 5 (2002) 788-798
74. Tohyama Y., Mück-Seler D., and Diksic M. Acute flesinoxan treatment produces a different effect on rat brain serotonin synthesis than chronic treatment: an α-methyl-l-tryptophan autoradiographic study. Neurochem. Int. 51 8 (2007) 486-495
75. Vanier M., Tsuiki K., Grdisa M., Worsley K., and Diksic M. Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis. J. Neurochem. 64 2 (1995) 624-635
76. Vizi E.S., Orsó E., Osipenko O.N., Haskó G., and Elenkov I.J. Neurochemical, electrophysiological and immunocytochemical evidence for a noradrenergic link between the sympathetic nervous system and thymocytes. Neuroscience 68 4 (1995) 1263-1276
77. Watanabe A., Hasegawa S., Nishi K., Nguyen K.Q., and Diksic M. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain Res. Bull. 69 2 (2006) 101-108
78. Watanabe A., Tohyama Y., Nguyen K.Q., Hasegawa S., Debonnel G., and Diksic M. Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. J. Neurochem. 85 2 (2003) 469-475
79. Yadid G., Nakash R., Deri I., Tamar G., Kinor N., Gispan I., and Zangen A. Elucidation of the neurobiology of depression: insights from a novel genetic animal model. Prog. Neurobiol. 62 (2000) 353-378
80. 14C]methyl-l-tryptophan. Biochem. Pharmacol. 62 11 (2001) 1481-1489
81. Zangen A., Overstreet D.H., and Yadid G. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. J. Neurochem. 69 6 (1997) 2477-2483