Effects of chronic fluoxetine treatment in the presence and absence of (±) pindolol: A microdialysis study

British Journal of Pharmacology

Volumn 130, Issue 4, 2000, Pages 797-804

  Dawson, L A ^a   Nguyen, H Q ^a   Smith, D I ^a   Schechter, L E ^a  

^a Neuroscience Research   (United States)

Author keywords

( )pindolol; 5 Hydroxytryptamine (5 HT, serotonin); 8 hydroxy 2 (di n propylamino)tetralin (8 OH DPAT); Fluoxetine; Frontal cortex; Microdialysis

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; FLUOXETINE; PINDOLOL; SEROTONIN; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFECT; FRONTAL CORTEX; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOXETINE; FRONTAL LOBE; MALE; MICRODIALYSIS; PINDOLOL; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS;

EID: 0034130350     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703378     Document Type: Article

References (52)

1. ARTIGAS, F., PEREZ, V. & ALVAREZ, E. (1994). Pindolol induces a rapid improvement of patients with depression treated with serotonin reuptake inhibitors. Arch. Gen. Psychiatry, 51, 248-251.
2. 1B receptors. Neuropharmacology, 35, 213-222.
3. BEL, N. & ARTIGAS, F. (1993). Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not raphe nuckei. Synapse, 15, 243-245.
4. BERMAN, R.M., DARNELL, A.M., MILLER, H.L., ANAND, A. & CHARNEY, D.S. (1997). Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial. Am. J. Psychiatry, 154, 37-43.
5. BLIER, P. & BERGERON, R. (1995). Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. J. Clin. Psychopharmacol., 15, 217-222.
6. BLIER, P. & DE MONTIGNY, C. (1994). Current advances and trends in the treatment of depression. Trends Pharmacol. Sci., 15, 220-226.
7. BLIER, P., DE MONTIGNY, C. & CHAPUT, Y. (1987). Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. J. Clin. Psychopharmacol., 7, 24-35.
8. BORDET, R., THOMAS, P. & DUPUIS, B. (1998). Effect of pindolol on onset of action of paroxetine in the treatment of major depression: intermediate analysis of a double-blind, placebo-controlled trial. Am. J. Psychiatry, 155, 1346-1351.
9. 1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats. Psychopharmacology, 117, 358-363.
10. 1A receptors in augmenting antidepressant activity in the mouse forced swimming test. Psychopharmacology, 136, 226-234.
11. 1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport, 10, 1441-1445.
12. CECI, A., BASCHIROTTO, A. & BORSINI, F. (1994). The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex. Neuropharmacology, 33, 709-713.
13. CHAPUT, Y., BLIER, P. & DE MONTIGNY, C. (1986). Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmeideberg's Arch. Pharmacol., 333, 342-348.
14. 1A autoreceptor in vivo. Br. J. Pharmacol., 124, 206-212.
15. 1A receptor antagonists on fluoxetine-induced changes in serotonin in rat frontal cortex. Eur. J. Pharmacol., 345, 41-46.
16. 1B/1D receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (±) pindolol. Neuropharmacologv, 39, 1044-1052.
17. DAWSON, L.A. & ROUTLEDGE, C. (1996). Differential effects of potassium channel blockers on extracellular levels of serotonin and dopamine in the striatum of conscious rats. Br. J. Pharmacol., 116, 3260-3264.
18. 1A receptor blockade, on extracellular concentrations of 5-HT: a microdialysis study. Soc. Neurosci. Abstr., 24, 438.11.
19. 1A receptors. Neurochem. Res., 21, 557-562.
20. FORNAL, C.A., MARTIN, F.J., METZLER, C.W. & JACOBS, B.L. (1999). Pindolol suppresses serotonergic neuronal activity and does not block the inhibition of serotonergic neurons produced by 8-hydroxy-2-(di-n-propylamino)tetralin in awake cats. J. Pharmacol. Exp. Ther., 291, 229-238.
21. 1A autoreceptors in the mechanism of action of serotonergic antidepressant drugs: recent findings from in vivo microdialysis studies. Fundam. Clin. Pharmacol., 10, 16-27.
22. 1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br. J. Pharmacol., 115, 1064-1070.
23. 4 receptors in rats. Naunyn-Schmiedeberg's Arch. Pharmacol., 356, 22-28.
24. 1B receptors. Neuropsychopharmacology, 21, 268-284.
25. 1B receptors with WAY100635 and GR127935. J. Neurochem., 68, 1159-1163.
26. GUNDLAH, C., HJORTH, S. & AUERBACH, S.B. (1997). Autoreceptor antagonists enhance the effect of the reuptake inhibitor citalopram on extracellular 5-HT: the effect persists after repeated citalopram treatment. Neuropharmacology, 36, 475-482.
27. 1A receptor-induced inhibition of 5-HT neuronal activity in the rat. Br. J. Pharmacol., 126, 1741-1750.
28. 1A autoreceptors by prolonged treatment with fluoxetine alone or with WAY100635. Soc. Neurosci. Abstr., 24, 687.12.
29. 1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study. J. Neurochem., 60, 776-779.
30. HJORTH, S. (1996). (-) Pindolol, but not buspirone, potentiates the citalopram-induced rise in extracellular 5-hydroxytryptamine. Eur. J. Pharmacol., 303, 183-186.
31. 1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis. Neuropharmacology, 33, 331-334.
32. 1A autoreceptors and the mode of action of selective serotonin reuptake inhibitors (SSRI). Behav. Brain Res., 73, 281-283.
33. 1A receptors or β-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo. Eur. J. Pharmacol., 316, 43-47.
34. HJORTH, S. & CARLSSON, A. (1985). (-)-Pindolol stereo specifically inhibits rat brain serotonin (5-HT) synthesis. Neuropharmacology, 24, 1143-1146.
35. HJORTH, S. & CARLSSON, A. (1986). Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors?. Eur. J. Pharmacol., 129, 131-138.
36. 1A (auto) receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology, 36, 461-465.
37. 1A receptors. Eur. J. Pharmacol., 260, 243-246.
38. 1A receptors in the effects of acute and chronic fluoxetine on extracellular serotonin in the frontal cortex. Pharmacol. Biochem. Behav., 54, 143-147.
39. 1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmeidebergs Arch. Pharmacol., 352, 141-148.
40. 1A agonist. J. Pharmacol. Exp. Ther., 279, 1035-1042.
41. MCASKILL, R., MIR, S. & TAYLOR, D. (1998). Pindolol augmentation of antidepressant therapy. Br. J. Psychiatry, 173, 203-208.
42. PAXINOS, G. & WATSON, C. (1986). The rat brain in stereotaxic coordinates. Academic Press, New York.
43. PEREZ, V., GILABERTE, I., FARIES, D., ALVAREZ, E. & ARTIGAS, F. (1997). Randomized, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment. Lancet, 349, 1594-1597.
44. 1A receptors: reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins. J. Pharmacol. Exp. Ther., 288, 98-106.
45. 1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology, 15, 349-360.
46. 1A antagonist WAY100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain. Neurosci. Letts., 219, 123-126.
47. RUTTER, J.J., GUNDLAH, C. & AUERBACH, S.B. (1994). Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neurosci. Letts., 171, 183-186.
48. SCHECHTER, L.E., MCGONIGLE, P. & BARRETT, J.E. (1999). Serotonergic antidepressants: Current and future perspectives. Curr. Opin. Cent. Periph. Nerv. Syst. Invest. Drugs, 1, 432-447.
49. 1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. Br. J. Pharmacol., 121, 941-946.
50. TOME, M.B., ISAAC, M.T., HARTE, R. & HOLLAND, C. (1997). Paroxetine and pindolol: a randomized trial of serotonergic autoreceptor blockade in the reduction of antidepressant latency. Int. Clin. Psychopharmacol., 12, 81-89.
51. ZANARDI, R., ARTIGAS, F., FRANCHINI, L., SFORZINI, L., GASPERINI, M., SMERALDI, E. & PEREZ, J. (1997). How long should pindolol be associated with paroxetine to improve the antidepressant response?. J. Clin. Psychopharmacol, 17, 446-450.
52. ZANARDI, R., FRANCHINI, L., GASPERINI, M., LUCCA, A., SMERALDI, E. & PEREZ, J. (1998). Faster onset of action of fluvoxamine in combination with pindolol in the treatment of delusional depression: a controlled study. J. Clin. Psychopharmacol., 18, 441-446.