Augmentation with a 5-HT(1A), but not a 5-HT(1B) receptor antagonist critically depends on the dose of citalopram

European Journal of Pharmacology

Volumn 397, Issue 1, 2000, Pages 63-74

  Cremers, Thomas I F H ^a   De Boer, Peter ^b   Liao, Yi ^a   Bosker, Fokko J ^c   Den Boer, Johan A ^c   Westerink, Ben H C ^a   Wikström, Håkan V ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Janssen Cilag BV Netherlands   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

5 Hydroxytryptamine, serotonin (5 HT); 5 Hydroxytryptamine, serotonin (5 HT) reuptake inhibitor, selective; Citalopram; Hippocampus; Microdialysis; ventral

Indexed keywords

AUTORECEPTOR; CITALOPRAM; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BRAIN LEVEL; HIPPOCAMPUS; MALE; MICRODIALYSIS; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE;

ANIMALS; AUTORECEPTORS; CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HIPPOCAMPUS; INJECTIONS, SUBCUTANEOUS; MALE; OXADIAZOLES; PIPERAZINES; PYRIDINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN AGENTS; TIME FACTORS;

EID: 0034716977     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00247-8     Document Type: Article

References (41)

1. 1A receptor antagonist (S)-UH-301 blocks the (R)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat. J. Neural Transm.: Gen. Sect. 96:1994;179-186.
2. Artigas F., Perez V., Alvarez E. Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch. Gen. Psychiatry. 51:1994;248-251.
3. Auerbach S.B., Hjorth S. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn-Schmiedeberg's Arch. Pharmacol. 352:1995;597-606.
4. Baumann P. Clinical pharmacokinetics of citalopram and other selective serotonergic reuptake inhibitors (SSRI). Int. Clin. Psychopharmacol. 6(Suppl. 5):1992;13-20.
5. Bel N., Artigas F. Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: an in vivo microdialysis study. Eur. J. Pharmacol. 229:1992;101-103.
6. Berman R.M., Darnell A.M., Miller H.L., Anand A., Charney D.S. Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial. Am. J. Psychiatry. 154:1997;37-43.
7. Blier P., de Montigny C., Chaput Y. Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. J. Clin. Psychopharmacol. 7:1987;24S-35S.
8. Bosker F.J., Donker M.G., Klompmakers A.A., Kurata K., Westenberg H.G. 5-Hydroxytryptamine release in dorsal hippocampus of freely moving rats: modulation by pindolol. Prog. Neuropsychopharmacol. Biol. Psychiatry. 18:1994;765-778.
9. Bosker F.J., Klompmakers A.A., Westenberg H.G. Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat. Neuropharmacology. 34:1995;501-508.
10. 1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats. Psychopharmacology (Berlin). 117:1995;358-363.
11. Chaput Y., de Montigny C., Blier P. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 333:1986;342-348.
12. 1B autoreceptors in rat lateral geniculate nucleus. Brain Res. 760:1997;238-242.
13. Fredricson Overø K. Kinetics of citalopram in test animals; drug exposure in safety studies. Prog. Neuropsychopharmacol. Biol. Psychiatry. 6:1982;297-309.
14. Fuller R.W. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci. 55:1994;163-167.
15. 1B receptors with WAY 100,635 and GR 127,935. J. Neurochem. 68:1997;1159-1163.
16. Gundlah C., Hjorth S., Auerbach S.B. Autoreceptor antagonists enhance the effect of the reuptake inhibitor citalopram on extracellular 5-HT: this effect persists after repeated citalopram treatment. Neuropharmacology. 36:1997;475-482.
17. Gundlah C., Simon L.D., Auerbach S.B. Differences in hypothalamic serotonin between estrous phases and gender: an in vivo microdialysis study. Brain Res. 785:1998;91-96.
18. Hjorth S. Serotonin 5-HT1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study. J. Neurochem. 60:1993;776-779.
19. 1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis. Neuropharmacology. 33:1994;331-334.
20. 1A receptors or beta-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo. Eur. J. Pharmacol. 316:1996;43-47.
21. 1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology. 36:1997;461-465.
22. Hyttel J. Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs). Int. Clin. Psychopharmacol. 9(Suppl. 1):1994;19-26.
23. 1A receptors. Eur. J. Pharmacol. 260:1994;243-246.
24. 1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus. Neuropharmacology. 36:1997;467-473.
25. 1A autoreceptors of the dorsal and median raphe nuclei. J. Pharmacol. Exp. Ther. 269:1994;1268-1279.
26. Kreiss D.S., Lucki I. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. J. Pharmacol. Exp. Ther. 274:1995;866-876.
27. 1A autoreceptors of the dorsal and median raphe nuclei. Synapse. 25:1997;107-116.
28. 1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's Arch. Pharmacol. 352:1995;141-148.
29. McAskill R., Mir S., Taylor D. Pindolol augmentation of antidepressant therapy. Br. J. Psychiatry. 173:1998;203-208.
30. McQuade R., Sharp T. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J. Neurochem. 69:1997;791-796.
31. Moret C., Briley M. Serotonin autoreceptor subsensitivity and antidepressant activity. Eur. J. Pharmacol. 180:1990;351-356.
32. Moret C., Briley M. Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain. Eur. J. Pharmacol. 295:1996;189-197.
33. Øyehaug E., Ostensen E.T., Salvesen B. Determination of the antidepressant agent citalopram and metabolites in plasma by liquid chromatography with fluorescence detection. J. Chromatogr. 227:1982;129-135.
34. Perez V., Gilaberte I., Faries D., Alvarez E., Artigas F. Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment. Lancet. 349:1997;1594-1597.
35. 1D antagonist and 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J. Neurochem. 67:1996;1996-2204.
36. 1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. J. Neurochem. 68:1997;2593-2603.
37. Schoups A.A., De Potter W.P. Species dependence of adaptations at the pre-and postsynaptic serotonergic receptors following long-term antidepressant drug treatment. Biochem. Pharmacol. 37:1988;4451-4460.
38. 1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. Br. J. Pharmacol. 121:1997;941-946.
39. Sproule B.A., Naranjo C.A., Brenmer K.E., Hassan P.C. Selective serotonin reuptake inhibitors and CNS drug interactions. A critical review of the evidence. Clin. Pharmacokinet. 33:1997;454-471.
40. 1B/1D autoreceptors modulate dorsal raphe cell firing? In vivo electrophysiological studies in guinea pigs with GR127935. Neuropharmacology. 36:1997;559-567.
41. 1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphe nucleus. Neuropharmacology. 33:1994;393-402.