Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease

Hepatology International

Volumn 2, Issue 1, 2008, Pages 39-49

  Deaciuc, Ion V ^a   Song, Zhenyuan ^a   Peng, Xuejun ^b   Barve, Shirish S ^a   Song, Ming ^a   He, Qiang ^a   Knudsen, Thomas B ^c   Singh, Amar V ^c   McClain, Craig J ^d  

^a University of Louisville School of Medicine   (United States)

^b TAKEDA PHARMACEUTICALS   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Fatty liver; Gene profiling; High carbohydrate diet; Mouse

Indexed keywords

CARBOHYDRATE; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; FEEDING; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE SEQUENCE; GENOME; MALE; MOLECULAR DYNAMICS; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRITION; PATHOGENESIS; PRIORITY JOURNAL; UPREGULATION;

EID: 69749108932     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-007-9025-2     Document Type: Article

References (40)

1. McClain CJ, Mokshagundam PL, Barve SS, Song Z, Hill DB, Chen T, Deaciuc I. Mechanisms of non-alcoholic steatohepatitis. Alcohol 2004;34:67-79.
2. Den Boer M, Voshol PG, Kuipers F, Havekes LM, Romijn JA. Hepatic steatosis: A mediator of the metabolic syndrome. Lessons from animal models. Artherioscl Thromb Vasc Biol 2004;24:644-9.
3. Koteish A, Diehl AM. Animal models of steatosis. Semin Liver Dis 2001;21:89-104.
4. Lieber CS, Leo MA, Mak KM, Xu Y, Cao Q, Ren C, et al. Model of non-alcoholic steatohepatitis. Am J Clin Nutr 2004;79:502-9.
5. Nanji AA. Animal models of nonalcoholic fatty liver disease and steatohepatitis. Clin Liver Dis 2004;8:559-74.
6. Portincasa P, Grattagliano I, Palmieri VO, Palasciano G. Nonalcoholic steatohepatitis: Recent advances from experimental models to clinical management. Clin Biochem 2005;38:203-17.
7. Deng QG, She H, Cheng JH, French SW, Koop DR, Xion S, et al. Steatohepatitis induced by intragastric overfeeding in mice. Hepatology 2005;42:905-14.
8. Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. Diet associated steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol 2003;39:978-83.
9. Friedman HA, Nylund B. Intestinal fat digestion, absorption and transport. Am J Clin Nutr 1980;33:1108-39.
10. Foufelle F, Girard J, Ferre P. Regulation of lipogenic enzyme expression by glucose in liver and adipose tissue: A review of the potential cellular and molecular mechanisms. Adv Enzyme Regul 1996;36:199-226.
11. Flatt JP. Conversion of carbohydrate to fat in the adipose tissue: An energy-yielding and, therefore, self-limiting process. J Lip Res 1970;11:131-43.
12. Basciano H, Federico L, Adeli K. Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab 2005;2:5. doi: 10.1186/1743-7075-2-5.
13. Diraison F, Yankah V, Letexier D, Dusserre E, Jones P, Beylot M. Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans. J Lipid Res 2003;44:846-53.
14. Hudgins L, Hellerstein M, Seidman C, Seidman C, Neese R, Diakun J, et al. Human fatty acid synthesis is stimulated by eucaloric low fat, high carbohydrate diet. J Clin Invest 1996;97:2081-91.
15. Schwartz JM, Linfoot P, Dare D, Aghajanian K. Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low carbohydrate and low-fat, high carbohydrate isoenergetic diets. Am J Clin Nutr 2003;77:43-50.
16. Quintanilha AT, Packer L, Davies JM, Racanelli TM, Davies KJ. Membrane effects of vitamin E deficiency: Bioenergetic and surface charge density studies of skeletal muscle and liver mitochondria. Ann NY Acad Sci 1982;393:32-47.
17. Deaciuc IV, Peng X, D'Souza NB, Shedlofsky SI, Burikhanov R. Microarray gene analysis of the liver in a rat model of chronic, voluntary alcohol uptake. Alcohol 2004;32:113-27.
18. Järveläinen HA, Fang C, Ingelman-Sundberg M, Lindros KO. Effect of chronic administration of endotoxin and ethanol on rat liver pathology and proinflammatory and antiinflammatory cytokines. Hepatology 1999;29:1602-14.
19. Bulera SJ, Eddy SM, Ferguson E, Jatkoe TA, Reindel JF, Bleavins MR, et al. RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology 2002;33:1239-58.
20. Deaciuc IV, Doherty DE, Burikhanov R, Lee EY, Stromberg AJ, Peng X, et al. Large-scale gene profiling of the liver in a mouse model of chronic, intragastric ethanol infusion. J Hepatol 2004;40:219-27.
21. Spencer AF, Lowenstein JM. The supply of precursors for the synthesis of fatty acids. J Biol Chem 1962;237:3640-8.
22. Wise EM, Ball EG. Malic enzyme and lipogenesis. Proc Natl Acad Sci USA 1964;52:1255-63.
23. Müller-Wieland D, Kotzka J. SREBP-1: Gene regulatory key to syndrome X? Ann NY Acad Sci 2002;967:19-27.
24. Eberle D, Hegarty B, Bossard P, Ferre P, Foufelle F. SREBP transcription factors: Master regulators of lipid homeostasis. Biochimie 2004;86:839-48.
25. Tan NS, Michalik L, Desvregne B, Wahli W. Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes. J Steroid Biochem Mol Biol 2005;93:99-105.
26. Dela Pena A, Leclerq I, Field J, George J, Jones B, Farrell G. NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepetitis. Gastroenterology 2005;129:1663-74.
27. Louthan MV, Barve S, McClain CJ, Joshi-Barve S. Decreased serum adiponectin: An early event in pediatric non-alcoholic fatty liver disease. J Pediatr 2005;147:835-8.
28. Ballestar E, Wolffe AP. Methyl-CpG-binding proteins. Targeting specific gene repression. Eur J Biochem 2001;268:1-6.
29. El-Osta A, Wolffe AP. DNA methylation and histone deacetylation in the control of gene expression: Basic biochemistry to human development and disease. Gene Expr 2000;9:63-75.
30. Mehlman MA. Dangerous and cancer-causing properties of products and chemicals in the oil refining and petrochemical industry. VIII. Health effects of motor fuels: Carcinogenicity of gasoline - scientific update. Environ Res 1992;59(1):238-49.
31. Cave M, Deaciuc IV, Mendez C, Song Z, Joshi-Barve S, Barve S, et al. Nonalcoholic fatty liver disease: Predisposing factors and the role of nutrition. J Nutr Biochem 2007;18:184-95.
32. Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. Can Med Assoc J 2005;172:899-905.
33. Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004;114:147-52.
34. Browning JD, Szczepaniak LS, Dobbins R, Nurember P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology 2004;40:1387-95.
35. Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 2004;10:1-7.
36. Hamaguchi M, Kojima T, Takeda N, Taniguchi H, Fujii K, Omatsu T, et al. The metabolic syndrome as a predictor of non-alcoholic fatty liver disease. Ann Intern Med 2005;143:722-8.
37. Villafuerte BC, Phillips LS, Rane MJ, Zhao W. Insulin-response element-binding protein 1. A novel Akt substrate involved in transcriptional action of insulin. J Biol Chem 2004;279:36650-9.
38. Villafuerte BC, Kaytor EN. An insulin-response element-binding protein that ameliorates hyperglycemia in diabetes. J Biol Chem 2005;280:20010-20.
39. Foufelle F, Ferre P. Regulation of carbohydrate metabolism by insulin: role of transcription factor SREBP-1c in the hepatic transcriptional effects of the hormone. J Soc Biol 2001;195:243-8.
40. Griffin MJ, Sul HS. Insulin regulation of fatty acid synthase gene transcription: Roles of USF and SREBP-1c. Life 2004;56:595-600.