Large-scale gene profiling of the liver in a mouse model of chronic, intragastric ethanol infusion

Journal of Hepatology

Volumn 40, Issue 2, 2004, Pages 219-227

  Deaciuc, Ion V ^a   Doherty, Dennis E ^b   Burikhanov, Ravshan ^b   Lee, Eun Y ^b   Stromberg, Arnold J ^c   Peng, Xuejun ^c   De Villiers, Willem J S ^b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alcohol induced liver injury; cDNA microarrays; Intragastric ethanol infusion; Large scale gene expression; Necrosis; Steatohepatitis; Total RNA

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; GLUCOSE; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATHETER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEATH; DIET; DOWN REGULATION; ENZYME ASSAY; FATTY LIVER; FEEDING; GASTROTOMY; GENE EXPRESSION PROFILING; GENE TECHNOLOGY; GENETIC ANALYSIS; HEPATITIS; INFUSION; LIQUID; LIVER HISTOLOGY; LIVER NECROSIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA; PRIORITY JOURNAL; RNA ANALYSIS; SCALE UP; STOMACH; UNINDEXED SEQUENCE; UPREGULATION;

EID: 1642450614     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2003.10.021     Document Type: Article

References (43)

1. Morimoto M., Hagbjörg A.-L., Nanji A.A., Ingelman-Sundberg M., Lindros K.O., Fu P.C., et al. Role of cytochrome P450 2E1 in alcohol liver disease pathogenesis. Alcohol. 10:1993;459-464.
2. Ronis M.J.J., Huang J., Crouch J., Mercado C., Irby D., Valentine C.R., et al. Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats. J Pharmacol Exp Ther. 264:1993;944-950.
3. Gordon A.S., Collier K., Diamond I. Ethanol regulation of adenosine receptor-stimulated cAMP levels in a cloned cell line: an invitro model of cellular tolerance to ethanol. Proc Natl Acad Sci USA. 83:1986;2105-2108.
4. L proteins. Oncogene. 21:2002;32-43.
5. S messenger RNA. Nature (London). 333:1988;848-850.
6. Deaciuc I.V., Fortunato F., D'Souza N.B., Hill D.B., Schmidt J., Lee E.Y., McClain C.J. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide. Alcohol Clin Exp Res. 23:1999;349-356.
7. Deaciuc I.V., D'Souza N.B., de Villiers W.J.S., Burikhanov R., Sarphie T.G., Hill D.B., McClain C.J. Inhibition of caspases in vivo protects the rat liver against alcohol-induced sensitization to bacterial lipopolysaccharide. Alcohol Clin Exp Res. 25:2001;935-943.
8. Deaciuc I.V., D'Souza N.B., Burikhanov R., Lee E.Y., Tarba C.N., McClain C.J., de Villiers W.J.S. Epidermal growth factor protects the liver against alcohol-induced injury and sensitization to bacterial lipopolysaccharide. Alcohol Clin Exp Res. 26:2002;864-874.
9. Deaciuc I.V., Fortunato F., D'Souza N.B., Hill D.B., McClain C.J. Chronic alcohol exposure of rats exacerbates apoptosis in hepatocytes and sinusoidal endothelial cells. Hepatol Res. 19:2002;306-324.
10. Koteish A., Yang S.Q., Lin H.Z., Huand X., Diehl A.M. Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting N-terminal kinase and caspase-3 activation. J Biol Chem. 277:2002;13037-13044.
11. Yacoub L.K., Fogt F., Griniuviene B., Nanji A.A. Apoptosis and Bcl-2 protein expression in experimental alcoholic liver disease in the rat. Alcohol Clin Exp Res. 19:1995;854-859.
12. 2 and cyclooxygenase-2. J Biol Chem. 275:2000;20136-20145.
13. Takase S., Takada A., Urashima S., Enyama K., Fujii M. Changes in the markers related to collagen synthesis in the liver of chronically alcohol-treated rats. Gastroenterol Jpn. 27:1992;54-60.
14. Zern M.A., Leo M.A., Giambrone M.A., Lieber C.S. Increased type I procollagen mRNA levels and in vitro protein synthesis in the baboon model of chronic alcoholic liver disease. Gastroenterology. 89:1985;1123-1131.
15. Deaciuc I.V. Alcohol and cytokine networks. Alcohol. 14:1997;421-430.
16. Lu S.C., Huang Z.Z., Yang J.M., Tsukamoto H. Effect of ethanol and high-fat feeding on hepatic γ-glutamylcysteine synthetase subunit expression in the rat. Hepatology. 30:1999;209-214.
17. Cassini A., Galli G., Salazano R., Ceni E., Francheschelli F., Rotella C.M., Surrenti C. Acetaldehyde induces c-fos and c-jun proto-oncogenes in fat storing cells culture through protein kinase C activation. Alcohol Alcohol. 29:1994;303-314.
18. Bulera S.J., Eddy S.M., Ferguson E., Jatkoe T.A., Reindel J.F., Bleavins M.R., De La Iglesia F.A. RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology. 33:2002;1239-1258.
19. Hansen T., Dangers M., Borlak J., Gerstmayer B., Tomiuk S., Hofmann K., Hübel F., et al. Compound profiling using cDNA array based differential expression of human and rat hepatocytes. Toxicol Sci. 66:2002;9-10. abstract 45.
20. Harries H.M., Fletcher S.T., Duggan C.M., Baker V.A. The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol In Vitro. 15:2001;309-405.
21. Hite R., Bowman M., Asileti U., Patel V., Smith R., Polavarapu R. Chronic alcohol induced tissue injury: microarray analyses of differential gene regulation. Fed Am Soc Exp Biol J. 16:2002;. Abstract 16713.
22. Shirota Y., Kaneko S., Honda M., Kawai H.F., Kobayashi K. Identification of differentially expressed genes in hepatocellular carcinoma with cDNA microarrays. Hepatology. 33:2001;832-840.
23. Shakel N.A., Gorrell M.D., McCaughan G.W. Gene array analysis and the liver. Hepatology. 36:2002;1313-1325.
24. Tsukamoto H., Reidelberger R.D., French S.W., Largman C. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol. 247:1984;R595-R599.
25. Järvelainen H.A., Ingelman-Sundberg M., Lindros K.O. Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and antiinflammatory cytokines. Hepatology. 29:1999;1503-1510.
26. Chomczinski P., Sacchi N. Single step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction. Anal Biochem. 62:1987;156-161.
27. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B. 57:1995;289-300.
28. French S.W. Intragastric ethanol infusion model for cellular and molecular studies of alcoholic liver disease. J Biomed Sci. 8:2001;20-27.
29. Uesugi T., Froh M., Arteel G.E., Bradford B.U., Wheeler M.D., Gäbele E., Isayama F., Thurman R.G. Role of lipopolysaccharide-binding protein in early alchol-induced liver injury in mice. J Immunol. 168:2002;2963-2969.
30. Yin M., Wheeler M.D., Kono H., Bradford B.U., Galucci R.M., Luster M.I., Thurman R.G. Essential role of tumor necrosis factor α in EtOH-induced liver injury in mice. Gastroenterology. 117:1999;942-952.
31. Watkins P.B. Role of cytochromes P450 in drug metabolism and hepatotoxicity. Semin Liv Dis. 10:1990;235-250.
32. Dalke D.D., Sorrell M.F., Casey C.A., Tuma D.J. Chronic ethanol administration impairs receptor- mediated endocytosis of epidermal growth factor by rat hepatocytes. Hepatology. 12:1990;1085-1091.
33. Brindley D.N. What factors control hepatic triacylglycerol accumulation in alcohol abuse? Biochem Soc Trans. 16:1998;251-253.
34. Polokoff M.A., Simon T.J., Harris R.A., Simon F.R., Iwahashi M. Chronic ethanol increases liver plasma membrane fluidity. Biochemistry. 24:1985;3114-3120.
35. Fernandez-Checa J.C., Ookhtens M., Kaplowitz N. Effects of chronic ethanol feeding on rat hepatocytic glutathione compartmentation, efflux and response to incubation with ethanol. J Clin Invest. 80:1987;57-62.
36. Hirano T., Kaplowitz N., Tsukamoto H., Kamimura S., Fernandez-Checa J.C. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology. 16:1992;1423-1427.
37. Tomita M., Itoh H., Ishikawa N., Higa A., Ide H., Murakumo Y., et al. Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell change. Biochem J. 311:1995;293-297.
38. Rodriguez S., Van Aken E., Van Bocx S., Attoub S., Nguyen Q.D., Westley B.R., et al. Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signaling. Fed Am Soc Exp Biol J. 17:2003;7-16.
39. Hoffmann F., Jagla W., Wiede A. Molecular medicine of TFF-peptides: from gut to brain. Histol Histopathol. 16:2001;319-334.
40. Nolan J.P., Camara D.S. Intestinal endotoxins and macrophages as mediators of liver injury. Trans Am Clin Chem Assoc. 100:1988;115-125.
41. Thurman R.G. Mechanisms of hepatic toxicity. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol. 275:1998;G605-G611.
42. Chang L.M.S., Bollum F.J. Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase. J Biol Chem. 246:1971;909-916.
43. Aroca P., Garcia-Borron J.C., Solano F., Lozano J.A. Regulation of mammalian melanogenesis I: partial purification and characterization of a dopachrom converting factor: dopachrome tautomerase. Biochim Biophys Acta. 1035:1990;266-275.