Tripchlorolide protects neuronal cells from microglia-mediated Β-amyloid neurotoxicity through inhibiting NF-κB and JNK signaling

GLIA

Volumn 57, Issue 11, 2009, Pages 1227-1238

  Pan, Xiao Dong ^a,b   Chen, Xiao Chun ^a,b   Zhu, Yuan Gui ^a,b   Chen, Li Min ^a,b   Zhang, Jing ^a,b   Huang, Tian Wen ^a,b   Ye, Qin Yong ^a   Huang, Hua Pin ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b BEIJING HOSPITAL   (China)

Author keywords

Alzheimer's disease; Mitogen activated protein kinase; Neuroinflammation; Nuclear factor B; Tripterygium

Indexed keywords

AMYLOID BETA PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRITE; PLANT EXTRACT; PROSTAGLANDIN E2; PYRROLIDINE DITHIOCARBAMATE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TRIPCHLOROLIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; EMBRYO; ENZYME INHIBITION; ENZYME REPRESSION; IN VITRO STUDY; MICROGLIA; MOUSE; NERVE CELL STIMULATION; NERVOUS SYSTEM INFLAMMATION; NEUROMODULATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRIPTERYGIUM; TRIPTERYGIUM WILFORDII;

AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CELL LINE; CELLS, CULTURED; DITERPENES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROIMMUNOMODULATION; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B P50 SUBUNIT; PEPTIDE FRAGMENTS; PHENANTHRENES;

EID: 69749088327     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20844     Document Type: Article

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