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Volumn 190, Issue 2, 2009, Pages 215-223

ABCC1, ABCC2 and ABCC3 are implicated in the transepithelial transport of the myco-estrogen zearalenone and its major metabolites

Author keywords

ABC transporters; Caco 2 cells; Epithelial cells; Mycotoxin; Zearalenol; Zearalenone

Indexed keywords

ABC TRANSPORTER; ALPHA ZEARALENOL; BETA ZEARALENOL; GLUCURONIDE; MULTIDRUG RESISTANCE PROTEIN 1; MYCOTOXIN; PROTEIN ABCC1; PROTEIN ABCC2; PROTEIN ABCC3; RHODAMINE 123; UNCLASSIFIED DRUG; VERLUKAST; ZEARALENONE;

EID: 69449104493     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.07.021     Document Type: Article
Times cited : (27)

References (58)
  • 1
    • 0031834404 scopus 로고    scopus 로고
    • P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels
    • Anderle P., Niederer E., Rubas W., Hilgendorf C., Spahn-Langguth H., Wunderli-Allenspach H., Merkle H., and Langguth P. P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels. J. Pharm. Sci. 87 (1998) 757-762
    • (1998) J. Pharm. Sci. , vol.87 , pp. 757-762
    • Anderle, P.1    Niederer, E.2    Rubas, W.3    Hilgendorf, C.4    Spahn-Langguth, H.5    Wunderli-Allenspach, H.6    Merkle, H.7    Langguth, P.8
  • 2
    • 0035286778 scopus 로고    scopus 로고
    • Caco-2 monolayers in experimental and theoretical predictions of drug transport
    • Artursson P., Palm K., and Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug. Deliv. 46 (2001) 27-43
    • (2001) Adv. Drug. Deliv. , vol.46 , pp. 27-43
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 4
    • 33747762650 scopus 로고    scopus 로고
    • Genotoxicity assessment of deoxynivalenol in the Caco-2 cell line model using the Comet assay
    • Bony S., Carcelen M., Olivier L., and Devaux A. Genotoxicity assessment of deoxynivalenol in the Caco-2 cell line model using the Comet assay. Toxicol. Lett. 166 (2006) 67-76
    • (2006) Toxicol. Lett. , vol.166 , pp. 67-76
    • Bony, S.1    Carcelen, M.2    Olivier, L.3    Devaux, A.4
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 7 (1976) 248-254
    • (1976) Anal. Biochem. , vol.7 , pp. 248-254
    • Bradford, M.1
  • 6
    • 31844455959 scopus 로고    scopus 로고
    • Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
    • Deeley R.G., and Cole S.P.C. Substrate recognition and transport by multidrug resistance protein 1 (ABCC1). FEBS Lett. 580 (2006) 1103-1111
    • (2006) FEBS Lett. , vol.580 , pp. 1103-1111
    • Deeley, R.G.1    Cole, S.P.C.2
  • 7
    • 0030787532 scopus 로고    scopus 로고
    • A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limits of the Caco-2 model
    • Delie F., and Rubas W. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limits of the Caco-2 model. Crit. Rev. Ther. Drug 14 (1997) 221-286
    • (1997) Crit. Rev. Ther. Drug , vol.14 , pp. 221-286
    • Delie, F.1    Rubas, W.2
  • 8
    • 0343306779 scopus 로고    scopus 로고
    • Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein
    • Essodaigui M., Broxterman H.J., and Garnier-Suillerot A. Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein. Biochemistry 37 (1998) 2243-2250
    • (1998) Biochemistry , vol.37 , pp. 2243-2250
    • Essodaigui, M.1    Broxterman, H.J.2    Garnier-Suillerot, A.3
  • 11
    • 34547840227 scopus 로고    scopus 로고
    • Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone
    • Fink-Gremmels J., and Malekinejad H. Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone. Anim. Feed Sci. Technol. 137 (2007) 326-341
    • (2007) Anim. Feed Sci. Technol. , vol.137 , pp. 326-341
    • Fink-Gremmels, J.1    Malekinejad, H.2
  • 12
    • 0028986245 scopus 로고
    • The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance
    • Gekeler V., Ise W., Sanders K.H., Ulrich W.R., and Beck J. The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance. Biochem. Biophys. Res. Commun. 208 (1995) 345-352
    • (1995) Biochem. Biophys. Res. Commun. , vol.208 , pp. 345-352
    • Gekeler, V.1    Ise, W.2    Sanders, K.H.3    Ulrich, W.R.4    Beck, J.5
  • 13
    • 0032744001 scopus 로고    scopus 로고
    • Structural, mechanistic and clinical aspects of MRP1
    • Hipfner D.R., Deeley R.G., and Cole S.P. Structural, mechanistic and clinical aspects of MRP1. Biochim. Biophys. Acta 1461 (1999) 359-376
    • (1999) Biochim. Biophys. Acta , vol.1461 , pp. 359-376
    • Hipfner, D.R.1    Deeley, R.G.2    Cole, S.P.3
  • 14
    • 0033985306 scopus 로고    scopus 로고
    • Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2)
    • Hirohashi T., Suzuki H., Chu X.Y., Tamai I., Tsuji A., and Sugiyama Y. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2). J. Pharmacol. Exp. Ther. 292 (2000) 265-270
    • (2000) J. Pharmacol. Exp. Ther. , vol.292 , pp. 265-270
    • Hirohashi, T.1    Suzuki, H.2    Chu, X.Y.3    Tamai, I.4    Tsuji, A.5    Sugiyama, Y.6
  • 15
    • 0034723163 scopus 로고    scopus 로고
    • ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)
    • Hirohashi T., Suzuki H., Takikawa H., and Sugiyama Y. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J. Biol. Chem. 275 (2000) 2905-3291
    • (2000) J. Biol. Chem. , vol.275 , pp. 2905-3291
    • Hirohashi, T.1    Suzuki, H.2    Takikawa, H.3    Sugiyama, Y.4
  • 16
    • 0031839226 scopus 로고    scopus 로고
    • Parallel functional and immunological detection of human multidrug resistance proteins, P-glycoprotein and MRP1
    • Hollo Z., Homoloya L., Hegedus T., Muller M., Szakacs G., Jakab K., Antal F., and Sarkadi B. Parallel functional and immunological detection of human multidrug resistance proteins, P-glycoprotein and MRP1. Anticancer Res. 18 (1998) 2981-2987
    • (1998) Anticancer Res. , vol.18 , pp. 2981-2987
    • Hollo, Z.1    Homoloya, L.2    Hegedus, T.3    Muller, M.4    Szakacs, G.5    Jakab, K.6    Antal, F.7    Sarkadi, B.8
  • 17
    • 33646497418 scopus 로고    scopus 로고
    • Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines
    • Huang R., Murry D.J., Kolwankar D., Hall S.D., and Foster D.R. Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochem. Pharmacol. 71 (2006) 1695-1704
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1695-1704
    • Huang, R.1    Murry, D.J.2    Kolwankar, D.3    Hall, S.D.4    Foster, D.R.5
  • 18
  • 19
    • 0032926354 scopus 로고    scopus 로고
    • Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
    • Kònig J., Rost D., Cui Y., and Keppler D. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 29 (1999) 1156-1163
    • (1999) Hepatology , vol.29 , pp. 1156-1163
    • Kònig, J.1    Rost, D.2    Cui, Y.3    Keppler, D.4
  • 23
    • 22344452122 scopus 로고    scopus 로고
    • Estimated dietary exposure to principal food mycotoxins from the first French Total Diet Study
    • Leblanc J., Tard A., Volatier J., and Verger P. Estimated dietary exposure to principal food mycotoxins from the first French Total Diet Study. Food Addit. Contam. 22 (2005) 652-672
    • (2005) Food Addit. Contam. , vol.22 , pp. 652-672
    • Leblanc, J.1    Tard, A.2    Volatier, J.3    Verger, P.4
  • 24
    • 0347755366 scopus 로고    scopus 로고
    • Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR)
    • Lee C.H. Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR). Curr. Med. Chem. Anti-Cancer Agents. 4 (2004) 43-52
    • (2004) Curr. Med. Chem. Anti-Cancer Agents. , vol.4 , pp. 43-52
    • Lee, C.H.1
  • 25
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie E.M., Deeley R.G., and Cole S.P.C. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 204 (2005) 216-237
    • (2005) Toxicol. Appl. Pharmacol. , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.C.3
  • 27
    • 0030962253 scopus 로고    scopus 로고
    • ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene
    • Loe D.W., Stewart R.K., Massey T.E., Deeley R.G., and Cole S.P. ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. Mol. Pharmacol. 6 (1997) 1034-1041
    • (1997) Mol. Pharmacol. , vol.6 , pp. 1034-1041
    • Loe, D.W.1    Stewart, R.K.2    Massey, T.E.3    Deeley, R.G.4    Cole, S.P.5
  • 28
    • 26944450472 scopus 로고    scopus 로고
    • Enzyme kinetics of zearalenone biotransformation: pH and cofactor effects
    • Malekinejad H., Maas-Bakker R., and Fink-Gremmels J. Enzyme kinetics of zearalenone biotransformation: pH and cofactor effects. Arch. Toxicol. 79 (2005) 547-553
    • (2005) Arch. Toxicol. , vol.79 , pp. 547-553
    • Malekinejad, H.1    Maas-Bakker, R.2    Fink-Gremmels, J.3
  • 29
    • 24944445105 scopus 로고    scopus 로고
    • Bioactivation of zearalenone by porcine hepatic biotransformation
    • Malekinejad H., Maas-Bakker R., and Fink-Gremmels J. Bioactivation of zearalenone by porcine hepatic biotransformation. Vet. Res. 36 (2005) 799-810
    • (2005) Vet. Res. , vol.36 , pp. 799-810
    • Malekinejad, H.1    Maas-Bakker, R.2    Fink-Gremmels, J.3
  • 30
    • 33645235792 scopus 로고    scopus 로고
    • Expression of 3α- and 3β-hydroxysteroid dehydrogenase mRNA in COCs and granulose cells determines zearalenone biotransformation
    • Malekinejad H., Van Tol H.T.A., Colenbrander B., and Fink-Gremmels J. Expression of 3α- and 3β-hydroxysteroid dehydrogenase mRNA in COCs and granulose cells determines zearalenone biotransformation. Toxicol. In Vitro 20 (2006) 458-463
    • (2006) Toxicol. In Vitro , vol.20 , pp. 458-463
    • Malekinejad, H.1    Van Tol, H.T.A.2    Colenbrander, B.3    Fink-Gremmels, J.4
  • 31
    • 0028786481 scopus 로고
    • The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications
    • Meunier V., Bourrie M., Berger Y., and Fabre G. The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications. Cell Biol. Toxicol. 11 (1995) 187-194
    • (1995) Cell Biol. Toxicol. , vol.11 , pp. 187-194
    • Meunier, V.1    Bourrie, M.2    Berger, Y.3    Fabre, G.4
  • 32
    • 18244390013 scopus 로고    scopus 로고
    • Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas
    • Nakamura T., Sakaeda T., Ohmoto N., Tamura T., et al. Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas. Drug Metab. Dispos. 30 (2002) 4-6
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 4-6
    • Nakamura, T.1    Sakaeda, T.2    Ohmoto, N.3    Tamura, T.4
  • 33
    • 0019364821 scopus 로고
    • Reduction of zearalenone to zearalenol in female rat liver by 3α-hydroxysteroid dehydrogenase
    • Olsen M., Pettersson H., and Kiessling K.H. Reduction of zearalenone to zearalenol in female rat liver by 3α-hydroxysteroid dehydrogenase. Acta Pharmacol. Toxicol. (Copenhagen) 48 (1981) 157-161
    • (1981) Acta Pharmacol. Toxicol. (Copenhagen) , vol.48 , pp. 157-161
    • Olsen, M.1    Pettersson, H.2    Kiessling, K.H.3
  • 37
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 9 (2001) e45
    • (2001) Nucleic Acids Res. , vol.29 , Issue.9
    • Pfaffl, M.W.1
  • 38
    • 6344242987 scopus 로고    scopus 로고
    • Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells
    • Prime-Chapman H.M., Fearn R.A., Cooper A.E., Moore A.E., and Hirst B.H. Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells. J. Pharmacol. Exp. Ther. 311 (2004) 476-484
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , pp. 476-484
    • Prime-Chapman, H.M.1    Fearn, R.A.2    Cooper, A.E.3    Moore, A.E.4    Hirst, B.H.5
  • 40
    • 0035794228 scopus 로고    scopus 로고
    • Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1
    • Qian Y.M., Song W.C., Cui H., Cole P.C., and Deeley R.G. Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. J. Biol. Chem. 9 (2001) 6404-6411
    • (2001) J. Biol. Chem. , vol.9 , pp. 6404-6411
    • Qian, Y.M.1    Song, W.C.2    Cui, H.3    Cole, P.C.4    Deeley, R.G.5
  • 41
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
    • Schinkel A.H., and Jonker J.W. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv. Drug Deliv. Rev. 55 (2003) 3-29
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 42
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel A.H., Wagenaar E., Van Deemter L., Mol C.A.A.M., and Borst P. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 96 (1995) 1698-1705
    • (1995) J. Clin. Invest. , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    Van Deemter, L.3    Mol, C.A.A.M.4    Borst, P.5
  • 43
    • 33645885302 scopus 로고    scopus 로고
    • Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells
    • Schrickx J., Lektarau Y., and Fink-Gremmels J. Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells. Arch. Toxicol. 80 (2006) 243-249
    • (2006) Arch. Toxicol. , vol.80 , pp. 243-249
    • Schrickx, J.1    Lektarau, Y.2    Fink-Gremmels, J.3
  • 44
    • 33747090656 scopus 로고    scopus 로고
    • Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells
    • Seithel A., Karlsson J., Hilgendorf C., Björquist A., and Ungell A.L. Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells. Eur. J. Pharm. Sci. 28 (2006) 291-299
    • (2006) Eur. J. Pharm. Sci. , vol.28 , pp. 291-299
    • Seithel, A.1    Karlsson, J.2    Hilgendorf, C.3    Björquist, A.4    Ungell, A.L.5
  • 46
    • 0034811602 scopus 로고    scopus 로고
    • Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers
    • Taipalensuu J., Törnblom H., Lindberg G., Einarsson C., Sjökvist F., Melhus H., Garberg P., Sjöström B., Lundgren B., and Artursson P. Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J. Pharmacol. Exp. Ther. 299 (2001) 164-170
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 164-170
    • Taipalensuu, J.1    Törnblom, H.2    Lindberg, G.3    Einarsson, C.4    Sjökvist, F.5    Melhus, H.6    Garberg, P.7    Sjöström, B.8    Lundgren, B.9    Artursson, P.10
  • 47
    • 28444484982 scopus 로고    scopus 로고
    • Expression and function of efflux transporters in the intestine
    • Takano M., Yumoto R., and Murakami T. Expression and function of efflux transporters in the intestine. Pharmacol. Ther. 109 (2006) 137-161
    • (2006) Pharmacol. Ther. , vol.109 , pp. 137-161
    • Takano, M.1    Yumoto, R.2    Murakami, T.3
  • 48
    • 34248172465 scopus 로고    scopus 로고
    • Transepithelial transport of fusariotoxin nivalenol: mediation of secretion by ABC transporters
    • Tep J., Videmann B., Mazallon M., Balleydier S., Cavret S., and Lecoeur S. Transepithelial transport of fusariotoxin nivalenol: mediation of secretion by ABC transporters. Toxicol. Lett. 170 (2007) 248-258
    • (2007) Toxicol. Lett. , vol.170 , pp. 248-258
    • Tep, J.1    Videmann, B.2    Mazallon, M.3    Balleydier, S.4    Cavret, S.5    Lecoeur, S.6
  • 49
    • 0142241274 scopus 로고    scopus 로고
    • Cellular uptake and efflux of the tea flavonoid (-)epicatechin-3-gallate in the human intestinal cell line Caco-2
    • Vaidyanathan J.B., and Walle T. Cellular uptake and efflux of the tea flavonoid (-)epicatechin-3-gallate in the human intestinal cell line Caco-2. J. Pharmacol. Exp. Ther. 307 (2003) 745-752
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 745-752
    • Vaidyanathan, J.B.1    Walle, T.2
  • 50
    • 34547810884 scopus 로고    scopus 로고
    • Epithelial transport of deoxynivalenol: involvement of human p-glycoprotein (ABCB1) and multidrug resistance associated protein 2 (ABCC2)
    • Videmann B., Tep J., Cavret S., and Lecoeur S. Epithelial transport of deoxynivalenol: involvement of human p-glycoprotein (ABCB1) and multidrug resistance associated protein 2 (ABCC2). Food Chem. Toxicol. 45 (2007) 1938-1947
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1938-1947
    • Videmann, B.1    Tep, J.2    Cavret, S.3    Lecoeur, S.4
  • 51
    • 52949100974 scopus 로고    scopus 로고
    • Metabolism and transfer of the mycotoxin zearalenone in human intestinal Caco-2 cells
    • Videmann B., Mazallon M., Tep J., and Lecoeur S. Metabolism and transfer of the mycotoxin zearalenone in human intestinal Caco-2 cells. Food Chem. Toxicol. 46 (2008) 3279-3286
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 3279-3286
    • Videmann, B.1    Mazallon, M.2    Tep, J.3    Lecoeur, S.4
  • 52
    • 0033051339 scopus 로고    scopus 로고
    • Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2
    • Walle U.K., Galijatovic A., and Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem. Pharmacol. 58 (1999) 431-438
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 431-438
    • Walle, U.K.1    Galijatovic, A.2    Walle, T.3
  • 53
    • 0029142558 scopus 로고
    • Heterogeneity in the human intestinal cell line Caco-2 leads to differences in transepithelial transport
    • Walter E., and Kissel T. Heterogeneity in the human intestinal cell line Caco-2 leads to differences in transepithelial transport. Eur. J. Pharm. Sci. 3 (1995) 230
    • (1995) Eur. J. Pharm. Sci. , vol.3 , pp. 230
    • Walter, E.1    Kissel, T.2
  • 56
    • 0032951089 scopus 로고    scopus 로고
    • Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds
    • Yumoto R., Murakami T., Nakamoto Y., Hasegawa R., Nagai J., and Takano M. Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds. J. Pharmacol. Exp. Ther. 289 (1999) 149-155
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 149-155
    • Yumoto, R.1    Murakami, T.2    Nakamoto, Y.3    Hasegawa, R.4    Nagai, J.5    Takano, M.6
  • 57
    • 33847660937 scopus 로고    scopus 로고
    • Detection fo Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line
    • Zaja R., Klobucar R.S., and Smital T. Detection fo Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line. Aquat. Toxicol. 81 (2007) 365-376
    • (2007) Aquat. Toxicol. , vol.81 , pp. 365-376
    • Zaja, R.1    Klobucar, R.S.2    Smital, T.3
  • 58
    • 33751251394 scopus 로고    scopus 로고
    • Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin
    • Zinedine A., Soriano J.M., Molto J.C., and Mañes J. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food Chem. Toxicol. 45 (2007) 1-18
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1-18
    • Zinedine, A.1    Soriano, J.M.2    Molto, J.C.3    Mañes, J.4


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