Expression of 3α- and 3β-hydroxy steroid dehydrogenase mRNA in COCs and granulosa cells determines Zearalenone biotransformation

Toxicology in Vitro

Volumn 20, Issue 4, 2006, Pages 458-463

  Malekinejad, H ^a   Van Tol, H T A ^a   Colenbrander, B ^a   Fink Gremmels, J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

zearalenol; zearalenol; Granulosa cells (GCs); Hydroxysteroid dehydrogenase (HSD); Zearalenone (ZEA)

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; ALPHA ZEARALENOL; ANDROSTANOLONE; MESSENGER RNA; PROGESTERONE; ZEARALENONE; 3 ALPHA HYDROXYSTEROID DEHYDROGENASE (B SPECIFIC); ESTROGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CELL ISOLATION; CONTROLLED STUDY; ENZYME SUBSTRATE; GRANULOSA CELL; LIVER MICROSOME; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; ANIMAL; CELL CULTURE; CYTOLOGY; ENZYMOLOGY; FEMALE; GENE EXPRESSION; GENETICS; METABOLISM; OOCYTE; PHYSIOLOGY;

ANIMALIA; SUIDAE; SUS SCROFA; ZEA MAYS;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); ANIMALS; BIOTRANSFORMATION; CELLS, CULTURED; ESTROGENS, NON-STEROIDAL; FEMALE; GENE EXPRESSION; GRANULOSA CELLS; OOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWINE; ZEARALENONE;

EID: 33645235792     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2005.09.007     Document Type: Article

References (24)

1. B. Bao, and H.A. Garverick Expression of steroidogenic enzyme and gonadotropin receptor genes in bovine follicles during ovarian follicular waves: a review J. Anim. Sci. 76 1998 1903 1921
2. B. Bao, H.A. Garverick, G.W. Smith, M.F. Smith, B.E. Salfen, and R.S. Youngquist Expression of messenger ribonucleic acid (mRNA) encoding 3beta-hydroxysteroid dehydrogenase delta4, delta5 isomerase (3beta-HSD) during recruitment and selection of bovine ovarian follicles: identification of dominant follicles by expression of 3beta-HSD mRNA within the granulosa cell layer Biol. Reprod. 56 1997 1466 1473
3. P.A. Boyd, and J.L. Wittliff Mechanism of Fusarium mycotoxin action in mammary gland J. Toxicol. Environ. Health 4 1978 1 8
4. W.G. Degtiar, and N.E. Kushlinsky 3alpha-Hydroxysteroid dehydrogenase in animal and human tissues Biochemistry (Moscow) 66 2001 256 266
5. N. Isobe, T. Nakao, and Y. Yoshimura Immunohistochemical localization of 3beta-hydroxysteroid dehydrogenase in the granulosa and theca interna layers of bovine cystic follicles J. Reprod. Dev. 49 2003 227 233
6. H. Jornvall, B. Persson, M. Krook, S. Atrian, R. Gonzalez-Duarte, J. Jeffery, and D. Ghosh Short-chain dehydrogenases/reductases (SDR) Biochemistry 34 1995 6003 6013
7. G.G. Kuiper, J.G. Lemmen, B. Carlsson, J.C. Corton, S.H. Safe, P.T. van der Saag, B. van der Burg, and J.A. Gustafsson Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta Endocrinology 139 1998 4252 4263
8. Y. Li, S. Ganta, F.B. Von Stein, D.E. Mason, B.M. Mitchell, and L.C. Freeman 4-Aminopyridine Decreases Progesterone Production by Porcine Granulosa Cells Reprod. Biol. Endocrinol. 1 2003 31
9. Malekinejad, H., Maas-Bakker, R.F., Fink-Gremmels, J., 2005. Species differences in the hepatic biotransformation of zearalenone. Vet. J. May 18 epub ahead of print.
10. R. Miura, K. Shiota, K. Noda, S. Yagi, T. Ogawa, and M. Takahashi Molecular cloning of cDNA for rat ovarian 20alpha-hydroxysteroid dehydrogenase (HSD1) Biochem. J. 299 Pt 2 1994 561 567
11. M. Olsen, and K.H. Kiessling Species differences in zearalenone-reducing activity in subcellular fractions of liver from female domestic animals Acta Pharmacol. Toxicol. (Copenh.) 52 1983 287 291
12. M. Olsen, H. Pettersson, and K.H. Kiessling Reduction of zearalenone to zearalenol in female rat liver by 3alpha-hydroxysteroid dehydrogenase Acta Pharmacol. Toxicol. (Copenh.) 48 1981 157 161
13. J.E. Pawlowski, M. Huizinga, and T.M. Penning Cloning and sequencing of the cDNA for rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase J. Biol. Chem. 266 1991 8820 8825
14. A.H. Payne, I.G. Abbaszade, T.R. Clarke, P.A. Bain, and C.H. Park The multiple murine 3beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression Steroids 62 1997 169 175
15. T.M. Penning Molecular endocrinology of hydroxysteroid dehydrogenases Endocr. Rev. 18 1997 281 305
16. T.M. Penning Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action Hum. Reprod. Update 9 2003 193 205
17. T.M. Penning, Y. Jin, S. Steckelbroeck, T. Lanisnik Rizner, and M. Lewis Structure-function of human 3alpha-hydroxysteroid dehydrogenases: genes and proteins Mol. Cell. Endocrinol. 215 2004 63 72
18. M.G. Redinbaugh, and R.B. Turley Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions Anal. Biochem. 153 1986 267 271
19. K.E. Richardson, W.M. Hagler Jr., C.L. Campbell, and P.B. Hamilton Production of zearalenone, T-2 toxin, and deoxynivalenol by Fusarium spp. isolated from plant materials grown in North Carolina Mycopathologia 90 1985 155 160
20. J. Simard, A.M. Moisan, and Y. Morel Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency Semin. Reprod. Med. 20 2002 255 276
21. P.K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson, and D.C. Klenk Measurement of protein using bicinchoninic acid Anal. Biochem. 150 1985 76 85
22. U. Tiemann, W. Tomek, F. Schneider, and J. Vanselow Effects of the mycotoxins alpha- and beta-zearalenol on regulation of progesterone synthesis in cultured granulosa cells from porcine ovaries Reprod. Toxicol. 17 2003 673 681
23. A. Von Teichman, H. Joerg, P. Werner, B. Brenig, and G. Stranzinger cDNA cloning and physical mapping of porcine 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase Anim. Genet. 32 2001 298 302
24. WHO (2000). International Programme on Chemical Safety: Safety Evaluation of certain Food Additives and Contaminants: Zearalenone, Series 44.