Simple detection of chemical mutagens by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow)

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 391, Issue 3, 1997, Pages 215-231

  Sasaki, Yu F ^a   Nishidate, Emi ^a   Izumiyama, Fusako ^a   Matsusaka, Naonori ^b   Tsuda, Shuji ^b  

^a HACHINOHE NATIONAL COLLEGE OF TECHNOLOGY   (Japan)

^b IWATE UNIVERSITY   (Japan)

Author keywords

Alkaline single cell gel electrophoresis (SCG) assay; Comet assay; Genotoxicity; Micronucleus inducing mutagen; Mouse; Multiple organ

Indexed keywords

AROMATIC AMINE; BENZO[A]PYRENE; BUFFER; CHEMICAL MUTAGEN; COLCHICINE; DNA; DNA FRAGMENT; EDETATE SODIUM; FLUOROURACIL; INORGANIC COMPOUND; MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER; METAL; METHYLNITRONITROSOGUANIDINE; MITOMYCIN C; PHENACETIN; POLYCYCLIC AROMATIC HYDROCARBON; POTASSIUM BROMATE; POTASSIUM CHROMATE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL NUCLEUS; CONTROLLED STUDY; DNA ALKYLATION; DNA CROSS LINKING; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG MECHANISM; GEL ELECTROPHORESIS; GENOTOXICITY; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIVER; LUNG; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TECHNIQUE; TISSUE HOMOGENATE;

ALKYLATING AGENTS; ANIMALS; BONE MARROW; COLCHICINE; CROSS-LINKING REAGENTS; ELECTROPHORESIS; FLUOROURACIL; KIDNEY; LIVER; LUNG; MALE; MICE; MICE, INBRED STRAINS; MITOMYCIN; MUTAGENICITY TESTS; MUTAGENS; PHENACETIN; POLYCYCLIC HYDROCARBONS, AROMATIC; SPLEEN;

ANIMALIA;

EID: 0030839678     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00073-9     Document Type: Article

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