Role of Nrf2 and oxidative stress on fenofibrate-induced hepatocarcinogenesis in rats

Toxicological Sciences

Volumn 106, Issue 2, 2008, Pages 339-349

  Nishimura, Jihei ^a,b   Dewa, Yasuaki ^a,b   Okamura, Toshiya ^b,c   Jin, Meilan ^a,d   Saegusa, Yukie ^a,b   Kawai, Masaomi ^a,b   Umemura, Takashi ^d   Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Fenofibrate; GST P; Hepatocarcinogenesis; Laser microdissection; Liver; Nrf2; Oxidative stress; Peroxisome proliferator; Rat

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DIETHYLNITROSAMINE; FENOFIBRATE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; FISCHER 344 RAT; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER RESECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; TUMOR PROMOTION;

ANIMALS; BODY WEIGHT; FEEDING BEHAVIOR; GENE EXPRESSION PROFILING; GLUTATHIONE PEROXIDASE; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NF-E2-RELATED FACTOR 2; ORGAN SIZE; OXIDATIVE STRESS; PROCETOFEN; RATS; RATS, INBRED F344;

ANIMALIA; RATTUS;

EID: 56649093048     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn174     Document Type: Article

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