Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice

Toxicologic Pathology

Volumn 36, Issue 7, 2008, Pages 950-957

  Kawai, Masaomi ^a,b   Jin, Meilan ^a,c   Nishimura, Jihei ^a,b   Dewa, Yasuaki ^a,b   Saegusa, Yukie ^a,b   Matsumoto, Sayaka ^a,b   Taniai, Eriko ^a   Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Cytokeratin 8 18; Fenofibrate; Liver; RasH2 mouse

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; CYCLIN D1; CYCLINE; CYTOKERATIN 18; CYTOKERATIN 8; FENOFIBRATE; MYC PROTEIN; N DIETHYLNITROSAMINE; NITROSAMINE; PROTEIN C JUN; UNCLASSIFIED DRUG; DIETHYLNITROSAMINE; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER STAGING; CANCER SUSCEPTIBILITY; CELL CYCLE; CONTROLLED STUDY; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; CARCINOGEN TESTING; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; LIVER; LIVER RESECTION; LIVER TUMOR; METABOLISM; METHODOLOGY; NONPARAMETRIC TEST; PATHOLOGY; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MUS;

ANIMALS; BODY WEIGHT; CARCINOGENICITY TESTS; DIETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; HEPATECTOMY; IMMUNOHISTOCHEMISTRY; KERATIN-18; KERATIN-8; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASES; PROCETOFEN; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC;

EID: 68149157498     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623308327118     Document Type: Article

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