Effect of fenofibrate on oxidative DNA damage and on gene expression related to cell proliferation and apoptosis in rats

Toxicological Sciences

Volumn 97, Issue 1, 2007, Pages 44-54

  Nishimura, Jihei ^a,b   Dewa, Yasuaki ^a,b   Muguruma, Masako ^a   Kuroiwa, Yuichi ^b,c   Yasuno, Hiroaki ^a   Shima, Tomomi ^a   Jin, Mailan ^d   Takahashi, Miwa ^c   Umemura, Takashi ^c   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

DNA damage; Fenofibrate; Hepatocarcinogenesis; Liver; Oxidative stress; Peroxisome proliferators activated receptor alpha agonist; Rat; ROS

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACYL COENZYME A; ACYL COENZYME A OXIDASE; ACYL COENZYME A OXIDASE 1; CARNITINE ACETYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE; CATALASE; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 25A; CHECKPOINT KINASE 1; CYCLIN D1; CYTOCHROME P450 4A1; DEOXYRIBONUCLEOPROTEIN; DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE 1; FENOFIBRATE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE YC2; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45ALPHA; LIPOFUSCIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NIBRIN; PROTEIN MLH1; PROTEIN XRCC5; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; 8-HYDROXY-2'-DEOXYGUANOSINE; APOPTOSIS REGULATORY PROTEIN; DEOXYGUANOSINE; DRUG DERIVATIVE; KI 67 ANTIGEN; MESSENGER RNA; PEROXISOME PROLIFERATOR; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIETARY INTAKE; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; ENZYME ACTIVITY; FISCHER 344 RAT; GENE EXPRESSION; HISTOPATHOLOGY; IN VITRO STUDY; LIVER CARCINOGENESIS; LIVER MICROSOME; MALE; MICROARRAY ANALYSIS; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BIOTRANSFORMATION; CELL TRANSFORMATION; DNA MICROARRAY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENETICS; LIPID METABOLISM; LIVER; METABOLISM; METHODOLOGY; PATHOLOGY; TIME;

RATTUS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BIOTRANSFORMATION; CATALASE; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DEOXYGUANOSINE; DNA DAMAGE; DNA REPAIR ENZYMES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; KI-67 ANTIGEN; LIPID METABOLISM; LIVER; MALE; MICROSOMES, LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PEROXISOME PROLIFERATORS; PROCETOFEN; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 34347219468     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm011     Document Type: Article

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