Manipulating neuropeptidergic pathways in humans: A novel approach to neuropharmacology?

European Journal of Pharmacology

Volumn 405, Issue 1-3, 2000, Pages 43-54

  Fehm, Horst Lorenz ^a   Perras, Boris ^a   Smolnik, Rüdiger ^a   Kern, Werner ^a   Born, Jan ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Cognition; Insulin; Intranasal administration; Melanocortin; Neuropeptide; Vasopressin

Indexed keywords

CORTICOTROPIN; INTERMEDIN DERIVATIVE; INTERMEDIN[4-10]; NEUROPEPTIDE; UNCLASSIFIED DRUG; VASOPRESSIN;

ATTENTION; BLOOD BRAIN BARRIER; BODY FAT; BODY WEIGHT; BRAIN; BRAIN FUNCTION; COGNITION; CONFERENCE PAPER; HUMAN; NEUROPHARMACOLOGY; PRIORITY JOURNAL; SHORT TERM MEMORY; SLEEP;

ADMINISTRATION, INTRANASAL; COGNITION; HUMAN; NEURAL PATHWAYS; NEUROPEPTIDES; NEUROPHARMACOLOGY;

EID: 0034730443     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00540-9     Document Type: Conference Paper

References (49)

1. Effects of chronic icv infusion of vasopressin on sleep-waking cycle in rats
2. Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey
3. The olfactory nerve and not the trigeminal nerve is the major site of CNS entry for mouse hepatitis virus, strain JHM
4. Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine
5. Insulin receptor substrate-1 (IRS-1) expression in rat brain
6. The behaviorally active peptide ACTH 4-10: measurement in plasma and pharmacokinetics in man
7. ACTH and attention in humans: a review
8. Dose-dependent influences on electrophysiological signs of attention in humans after neuropeptide ACTH 4-10
9. Gluco- and antimineralo-corticoid effects on human sleep: a role of central corticosteroid receptors
10. Vasopressin regulates human sleep by reducing rapid-eye-movement sleep
11. Neuropsychological effects of vasopressin in healthy humans
12. Vasopressin-deficient rats show a reduced amplitude of the circadian sleep rhythm
13. Memory improvment following induced hyperinsulinemia in Alzheimer's disease
14. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease
15. Sleep deficits in rats with hereditary diabetes insipidus
16. Neuropeptides: animal behaviour and human psychopathology
17. Effects of vasopressin on event-related potential indicators of cognitive stimulus processing in young and old humans
18. Effects of pulsatile cortisol infusion on sleep-EEG and nocturnal growth hormone release in healthy men
19. Short-term or long-term intracerebroventricular (i.c.v.) infusion of insulin exhibits a discrete anabolic effect on cerebral energy metabolism in the rat
20. Intranasal insulin. Clinical pharmacokinetics
21. Central nervous system effects of intranasally administered insulin during euglycemia in humans
22. Selective increase in cerebral spinal fluid concentrations of insulin after intranasal insulin administration
23. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
24. Effects of enhanced cerebrospinal fluid levels of vasopressin, vasopressin antagonist or vasoactive intestinal polypeptide on circadian sleep-wake rhythm in the rat
25. Changes in information processing during a hypoglycemic clamp in type-II-diabetic patients
26. Effect of hyperinsulinemia on local cerebral insulin binding and glucose utilization in normoglycemic awake rats
27. Processing negativity: an evoked-potential reflection of selective attention
28. The effect of vasopressin on memory in the healthy elderly
29. Memory search and visual spatial attention: an event related brain potential analysis
30. Sleep and signs of attention during 3 month of intranasal vasopressin: a pilot study in two elderly subjects
31. Beneficial treatment of age-related sleep disturbances with prolonged intranasal vasopressin
32. Brain potential changes after intranasal versus intravenous administration of vasopressin: functional evidence for a facilitated nose-brain passage for peptides
33. Action of the diabetogenic drug streptozotocin on glycolytic metabolism in adult brain and hippocampus
34. Geriatrics: sleep disorders and aging
35. Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid
36. Insulin in the brain: a hormonal regulator of energy balance
37. Differentiation of hypoglycemia induced cognitive impairments
38. Brain potentials and attention after acute and subchronic intranasal administration of ACTH 4-10 and desacetyl-α-MSH in humans
39. Does DGAVP influence memory, attention and mood in young healthy men?
40. Ageing of the human hypothalamus
41. Isolation of specific interference processing in the stroop task: PET activation studies
42. Action of lysin vasopressin on human electroencephalographic activity
43. Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects
44. Neuropeptides: effects on paradoxical sleep and theta rhythm in rats
45. Behavioral effects of vasopressin
46. Vasopressin-related peptides increase the hippocampal corticosterone receptor capacity of diabetes insipidus (Brattleboro) rats
47. The hippocampus and the orienting reflex