Host cell detection of noncoding stuffer DNA contained in helper-dependent adenovirus vectors leads to epigenetic repression of transgene expression

Journal of Virology

Volumn 83, Issue 17, 2009, Pages 8409-8417

  Ross, P Joel ^a,b,c   Kennedy, Michael A ^a,b   Parks, Robin J ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BACTERIAL DNA; DAXX PROTEIN; HELPER DEPENDENT ADENOVIRUS VECTOR; HIGH MOBILITY GROUP PROTEIN; HISTONE DEACETYLASE; NUCLEAR FACTOR; UNCLASSIFIED DRUG; VIRUS DNA; DNA; HISTONE;

ACETYLATION; ARTICLE; CHROMATIN; CHROMATIN STRUCTURE; CONTROLLED STUDY; CPG ISLAND; DEACETYLATION; DNA METHYLATION; EMBRYO; EPIGENETICS; EXPRESSION VECTOR; FEMALE; GENE EXPRESSION; GENE INSERTION; GENE REPRESSION; GENETIC ASSOCIATION; GENOME; HELPER VIRUS; HOST CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; INSULATOR ELEMENT; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROKARYOTE; TRANSGENE; ADENOVIRUS; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; METABOLISM; PROTEIN BINDING;

ADENOVIRIDAE; BACTERIA (MICROORGANISMS); EUKARYOTA; PROKARYOTA;

ADENOVIRIDAE; CHROMATIN; DNA; DNA, VIRAL; GENE EXPRESSION; GENETIC VECTORS; HELPER VIRUSES; HISTONE DEACETYLASES; HISTONES; PROTEIN BINDING; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 69249206786     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00796-09     Document Type: Article

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