DNA genome size affects the stability of the adenovirus virion

Journal of Virology

Volumn 83, Issue 4, 2009, Pages 2025-2028

  Smith, Adam C ^a   Poulin, Kathy L ^a   Parks, Robin J ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA; VIRUS PROTEIN;

ADENOVIRUS; ARTICLE; DEFECTIVE VIRUS; GENETIC CODE; GENOME SIZE; GENOMIC INSTABILITY; HELPER VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRENGTH; THERMOSTABILITY; VIRION; VIRUS CAPSID; VIRUS GENOME; VIRUS REPLICATION;

ADENOVIRIDAE; DNA, VIRAL; MOLECULAR WEIGHT; VIRION;

ADENOVIRIDAE; MIRIDAE;

EID: 59649102993     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01644-08     Document Type: Article

References (32)

1. Addison, C. L., M. Hitt, D. Kunsken, and F. L. Graham. 1997. Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors. J. Gen. Virol. 78:1653-1661.
2. Amalfitano, A., and R. J. Parks. 2002. Separating fact from fiction: assessing the potential of modified adenovirus vectors for use in human gene therapy. Curr. Gene Ther. 2:111-133.
3. Bett, A. J., W. Haddara, L. Prevec, and F. L. Graham. 1994. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA 91:8802-8806.
4. Bett, A. J., L. Prevec, and F. L. Graham. 1993. Packaging capacity and stability of human adenovirus type 5 vectors. J. Virol. 67:5911-5921.
5. Bramson, J. L., N. Grinshtein, R. A. Meulenbroek, J. Lunde, D. Kottachchi, I. A. Lorimer, B. J. Jasmin, and R. J. Parks. 2004. Helper-dependent adenoviral vectors containing modified fibre for improved transduction of developing and mature muscle cells. Hum. Gene Ther. 15:179-188.
6. Brown, D. T., M. Westphal, B. T. Burlingham, U. Winterhoff, and W. Doerfler. 1975. Structure and composition of the adenovirus type 2 core. J. Virol. 16:366-387.
7. Chatterjee, P. K., M. E. Vayda, and S. J. Flint. 1986. Identification of proteins and protein domains that contact DNA within adenovirus nucleoprotein cores by ultraviolet light crosslinking of oligonucleotides 32P-labelled in vivo. J. Mol. Biol. 188:23-37.
8. Chatterjee, P. K., M. E. Vayda, and S. J. Flint. 1985. Interactions among the three adenovirus core proteins. J. Virol. 55:379-386.
9. Colby, W. W., and T. Shenk. 1981. Adenovirus type 5 virions can be assembled in vivo in the absence of detectable polypeptide IX. J. Virol. 39:977-980.
10. Everitt, E., L. Lutter, and L. Philipson. 1975. Structural proteins of adenoviruses. XII. Location and neighbor relationship among proteins of adenovirion type 2 as revealed by enzymatic iodination, immunoprecipitation and chemical cross-linking. Virology 67:197-208.
11. Everitt, E., B. Sundquist, U. Pettersson, and L. Philipson. 1973. Structural proteins of adenoviruses. X. Isolation and topography of low molecular weight antigens from the virion of adenovirus type 2. Virology 52:130-147.
12. Fabry, C. M., M. Rosa-Calatrava, J. F. Conway, C. Zubieta, S. Cusack, R. W. Ruigrok, and G. Schoehn. 2005. A quasi-atomic model of human adenovirus type 5 capsid. EMBO J. 24:1645-1654.
13. Greber, U. F., M. Willetts, P. Webster, and A. Helenius. 1993. Stepwise dismantling of adenovirus 2 during entry into cells. Cell 75:477-486.
14. Hubberstey, A. V., M. Pavliv, and R. J. Parks. 2002. Cancer therapy utilizing an adenoviral vector expressing only E1A. Cancer Gene Ther. 9:321-329.
15. Lieber, A., C. Y. He, I. Kirillova, and M. A. Kay. 1996. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J. Virol. 70:8944-8960.
16. Maelandsmo, G. M., P. J. Ross, M. Pavliv, R. A. Meulenbroek, C. Evelegh, D. A. Muruve, F. L. Graham, and R. J. Parks. 2005. Use of a murine secreted alkaline phosphatase as a non-immunogenic reporter gene in mice. J. Gene Med. 7:307-315.
17. Maizel, J. V., Jr., D. O. White, and M. D. Scharff. 1968. The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion. Virology 36:126-136.
18. Matthews, D. A., and W. C. Russell. 1998. Adenovirus core protein V is delivered by the invading virus to the nucleus of the infected cell and later in infection is associated with nucleoli. J. Gen. Virol. 79:1671-1675.
19. Mirza, M. A., and J. Weber. 1982. Structure of adenovirus chromatin. Biochim. Biophys. Acta 696:76-86.
20. Newcomb, W. W., J. W. Boring, and J. C. Brown. 1984. Ion etching of human adenovirus 2: structure of the core. J. Virol. 51:52-56.
21. Palmer, D., and P. Ng. 2003. Improved system for helper-dependent adenoviral vector production. Mol. Ther. 8:846-852.
22. Parks, R. J. 2005. Adenovirus protein IX: a new look at an old protein. Mol. Ther. 11:19-25.
23. Parks, R. J., L. Chen, M. Anton, U. Sankar, M. A. Rudnicki, and F. L. Graham. 1996. A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Natl. Acad. Sci. USA 93:13565-13570.
24. Parks, R. J., and F. L. Graham. 1997. A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging. J. Virol. 71:3293-3298.
25. Ross, P. J., and R. J. Parks. 2006. Construction of first-generation adenoviral vectors, p. 149-165. In T. Freidman and J. Rossi (ed.), Gene therapy vectors: a techniques manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
26. Russell, W. C., W. G. Laver, and P. J. Sanderson. 1968. Internal components of adenovirus. Nature 219:1127-1130.
27. Sargent, K., R. A. Meulenbroek, and R. J. Parks. 2004. Activation of adenoviral gene expression by protein IX is not required for efficient virus replication. J. Virol. 78:5032-5037.
28. Shayakhmetov, D. M., Z. Y. Li, A. Gaggar, H. Gharwan, V. Ternovoi, V. Sandig, and A. Lieber. 2004. Genome size and structure determine efficiency of postinternalization steps and gene transfer of capsid-modified adenovirus vectors in a cell-type-specific manner. J. Virol. 78:10009-10022.
29. Stewart, P. L., S. D. Fuller, and R. M. Burnett. 1993. Difference imaging of adenovirus: bridging the resolution gap between X-ray crystallography and electron microscopy. EMBO J. 12:2589-2599.
30. Ugai, H., A. V. Borovjagin, L. P. Le, M. Wang, and D. T. Curiel. 2007. Thermostability/infectivity defect caused by deletion of the core protein V gene in human adenovirus type 5 is rescued by thermo-selectable mutations in the core protein X precursor. J. Mol. Biol. 366:1142-1160.
31. Wickham, T. J., P. Mathias, D. A. Cheresh, and G. R. Nemerow. 1993. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73:309-319.
32. Wiethoff, C. M., H. Wodrich, L. Gerace, and G. R. Nemerow. 2005. Adenovirus protein VI mediates membrane disruption following capsid disassembly. J. Virol. 79:1992-2000.