Amyloid-β interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons

Journal of Neuroscience Research

Volumn 87, Issue 10, 2009, Pages 2297-2307

  Chen, Tsan Ju ^a   Wang, Dean Chuan ^a   Chen, Shun Sheng ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Alzheimer's disease; Cultured cortical neurons; eEF2; Synaptic plasticity

Indexed keywords

ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; ELONGATION FACTOR 2; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S6 KINASE; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); APOPTOSIS REGULATORY PROTEIN; ENZYME INHIBITOR; MUSCLE PROTEIN; NOL3 PROTEIN, RAT; ONCOPROTEIN; PEPTIDE FRAGMENT; PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; NERVE CELL PLASTICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANALYSIS OF VARIANCE; ANIMAL; BRAIN CORTEX; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT; TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS REGULATORY PROTEINS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; MUSCLE PROTEINS; NEURONS; ONCOGENE PROTEIN V-AKT; PEPTIDE FRAGMENTS; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 69249203877     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22057     Document Type: Article

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