The noncatalytic C-terminus of AtPOLK Y-family DNA polymerase affects synthesis fidelity, mismatch extension and translesion replication

FEBS Journal

Volumn 274, Issue 13, 2007, Pages 3340-3350

  García Ortiz, María Victoria ^a   Roldán Arjona, Teresa ^a   Ariza, Rafael R ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Arabidopsis thaliana; Base pair mismatch; DNA damage; DNA replication; Translesion DNA synthesis

Indexed keywords

8 HYDROXYGUANINE; DNA POLYMERASE; MUTANT PROTEIN; PROTEIN ATPOLK; UNCLASSIFIED DRUG;

ARABIDOPSIS; ARTICLE; BASE MISPAIRING; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPARATIVE STUDY; DNA BINDING; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; DNA TEMPLATE; ENZYME ACTIVITY; MISMATCH REPAIR; PLANT; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN STRUCTURE; STRUCTURAL GENE;

AMINO ACID MOTIFS; ARABIDOPSIS; BASE PAIR MISMATCH; BASE SEQUENCE; DNA; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; KINETICS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PROTEIN STRUCTURE, TERTIARY;

ARABIDOPSIS; ARABIDOPSIS THALIANA; MAMMALIA;

EID: 34347371785     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.05868.x     Document Type: Article

References (40)

1. Friedberg EC (2005) Suffering in silence: the tolerance of DNA damage. Nat Rev Mol Cell Biol 6, 943 953.
2. Prakash S, Johnson RE Prakash L (2005) Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem 74, 317 353.
3. Lehmann AR (2006) Translesion synthesis in mammalian cells. Exp Cell Res 312, 2673 2676.
4. Ohmori H, Friedberg EC, Fuchs RP, Goodman MF, Hanaoka F, Hinkle D, Kunkel TA, Lawrence CW, Livneh Z, Nohmi T, et al. (2001) The Y-family of DNA polymerases. Mol Cell 8, 7 8.
5. Yang W (2005) Portraits of a Y-family DNA polymerase. FEBS Lett 579, 868 872.
6. Kunkel TA (2004) DNA replication fidelity. J Biol Chem 279, 16895 16898.
7. Woodgate R (1999) A plethora of lesion-replicating DNA polymerases. Genes Dev 13, 2191 2195.
8. Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA Ellenberger T (2006) DNA Repair and Mutagenesis, 2nd edn. ASM Press, Washington, D.C.
9. Johnson RE, Washington MT, Prakash S Prakash L (1999) Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA. Proc Natl Acad Sci USA 96, 12224 12226.
10. Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K Dikic I (2005) Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 310, 1821 1824.
11. Plosky BS, Vidal AE, de Henestrosa AR, McLenigan MP, McDonald JP, Mead S Woodgate R (2006) Controlling the subcellular localization of DNA polymerases ι and ε via interactions with ubiquitin. EMBO J 25, 2847 2855.
12. García-Ortiz MV, Ariza RR, Hoffman PD, Hays JB Roldan-Arjona T (2004) Arabidopsis thaliana AtPOLK encodes a DinB-like DNA polymerase that extends mispaired primer termini and is highly expressed in a variety of tissues. Plant J 39, 84 97.
13. Gerlach VL, Feaver WJ, Fischhaber PL Friedberg EC (2001) Purification and characterization of pol κ, a DNA polymerase encoded by the human DINB1 gene. J Biol Chem 276, 92 98.
14. Mendez J, Blanco L, Lazaro JM Salas M (1994) Primer-terminus stabilization at the φ29 DNA polymerase active site. Mutational analysis of conserved motif TX2GR. J Biol Chem 269, 30030 30038.
15. Johnson RE, Washington MT, Haracska L, Prakash S Prakash L (2000) Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions. Nature 406, 1015 1019.
16. Johnson RE, Washington MT, Prakash S Prakash L (2000) Fidelity of human DNA polymerase ε. J Biol Chem 275, 7447 7450.
17. Washington MT, Johnson RE, Prakash S Prakash L (1999) Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase ε. J Biol Chem 274, 36835 36838.
18. Johnson RE, Prakash S Prakash L (2000) The human DINB1 gene encodes the DNA polymerase Polθ. Proc Natl Acad Sci USA 97, 3838 38343.
19. Zhang Y, Yuan F, Xin H, Wu X, Rajpal DK, Yang D Wang Z (2000) Human DNA polymerase κ synthesizes DNA with extraordinarily low fidelity. Nucleic Acids Res 28, 4147 4156.
20. Wolfle WT, Washington MT, Prakash L Prakash S (2003) Human DNA polymerase κ uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions. Genes Dev 17, 2191 2199.
21. Shibutani S, Takeshita M Grollman AP (1991) Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349, 431 434.
22. Miller H Grollman AP (1997) Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis. Biochemistry 36, 15336 15342.
23. Cordonnier AM Fuchs RP (1999) Replication of damaged DNA: molecular defect in xeroderma pigmentosum variant cells. Mutat Res 435, 111 119.
24. Pages V Fuchs RP (2002) How DNA lesions are turned into mutations within cells? Oncogene 21, 8957 8966.
25. Uljon SN, Johnson RE, Edwards TA, Prakash S, Prakash L Aggarwal AK (2004) Crystal structure of the catalytic core of human DNA polymerase kappa. Structure (Camb) 12, 1395 1404.
26. Ohashi E, Bebenek K, Matsuda T, Feaver WJ, Gerlach VL, Friedberg EC, Ohmori H Kunkel TA (2000) Fidelity and processivity of DNA synthesis by DNA polymerase κ, the product of the human DINB1 gene. J Biol Chem 275, 39678 39684.
27. Beard WA, Shock DD, Vande Berg BJ Wilson SH (2002) Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J Biol Chem 277, 47393 47398.
28. Showalter AK, Lamarche BJ, Bakhtina M, Su MI, Tang KH Tsai MD (2006) Mechanistic comparison of high-fidelity and error-prone DNA polymerases and ligases involved in DNA repair. Chem Rev 106, 340 360.
29. Haracska L, Kondratick CM, Unk I, Prakash S Prakash L (2001) Interaction with PCNA is essential for yeast DNA polymerase ε function. Mol Cell 8, 407 415.
30. Haracska L, Unk I, Johnson RE, Phillips BB, Hurwitz J, Prakash L Prakash S (2002) Stimulation of DNA synthesis activity of human DNA polymerase κ by PCNA. Mol Cell Biol 22, 784 791.
31. Moriya M (1993) Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoGuanine in DNA induces targeted G·C → T·A transversions in simian kidney cells. Proc Natl Acad Sci USA 90, 1122 1126.
32. Haracska LYuSL, Johnson RE, Prakash L Prakash S (2000) Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoGuanine by DNA polymerase ε. Nat Genet 25, 458 461.
33. Yuan F, Zhang Y, Rajpal DK, Wu X, Guo D, Wang M, Taylor JS Wang Z (2000) Specificity of DNA lesion bypass by the yeast DNA polymerase ε. J Biol Chem 275, 8233 8239.
34. Rechkoblit O, Malinina L, Cheng Y, Kuryavyi V, Broyde S, Geacintov NE Patel DJ (2006) Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. PLoS Biol 4, e11.
35. Zang H, Irimia A, Choi JY, Angel KC, Loukachevitch LV, Egli M Guengerich FP (2006) Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. J Biol Chem 281, 2358 2372.
36. Haracska L, Prakash L Prakash S (2002) Role of human DNA polymerase κ as an extender in translesion synthesis. Proc Natl Acad Sci USA 99, 16000 16005.
37. Zhang Y, Yuan F, Wu X, Wang M, Rechkoblit O, Taylor JS, Geacintov NE Wang Z (2000) Error-free and error-prone lesion bypass by human DNA polymerase κin vitro. Nucleic Acids Res 28, 4138 4146.
38. Jaloszynski P, Ohashi E, Ohmori H Nishimura S (2005) Error-prone and inefficient replication across 8-hydroxyguanine (8-oxoGuanine) in human and mouse ras gene fragments by DNA polymerase κ. Genes Cells 10, 543 550.
39. Zhang Y, Yuan F, Wu X, Taylor JS Wang Z (2001) Response of human DNA polymerase ι to DNA lesions. Nucleic Acids Res 29, 928 935.
40. Johnson RE, Haracska L, Prakash L Prakash S (2006) Role of hoogsteen edge hydrogen bonding at template purines in nucleotide incorporation by human DNA polymerase ι. Mol Cell Biol 26, 6435 6441.