Mutagenesis studies toward understanding allostery in thrombin

Biochemistry

Volumn 48, Issue 34, 2009, Pages 8261-8270

  Qureshi, Shabir H ^a   Yang, Likui ^a   Manithody, Chandrashekhara ^a   Iakhiaev, Alexei V ^b   Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SOUTH TEXAS COLLEGE OF LAW   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ACTIVE SITE; ALLOSTERY; AMIDOLYTIC ACTIVITIES; BINDING LOOP; CATALYTIC ACTIVITY; CATALYTIC RESIDUE; COFACTOR BINDING; COFACTORS; CYS RESIDUES; DISULFIDE BONDS; MAMMALIAN CELLS; SUBSTRATE SPECIFICITY; THROMBOMODULIN;

BINDING ENERGY; CONFORMATIONS; DYES; GLYCOPROTEINS; LABELS; MAMMALS; POLYSACCHARIDES; SODIUM;

BINDING SITES;

ACTIVATED PROTEIN C; HEPARIN; MUTANT PROTEIN; SODIUM ION; THROMBIN; THROMBOMODULIN;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; CATALYSIS; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; CATALYTIC DOMAIN; CATTLE; CRICETINAE; DISULFIDES; ENZYME ACTIVATION; HEPARIN; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS; MUTANT PROTEINS; MUTATION; PEPTIDE HYDROLASES; SODIUM; THROMBIN;

MAMMALIA;

EID: 69249094653     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900921t     Document Type: Article

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