Effects of Activation Peptide Bond Cleavage and Fragment 2 Interactions on the Pathway of Exosite I Expression during Activation of Human Prethrombin 1 to Thrombin

Journal of Biological Chemistry

Volumn 278, Issue 45, 2003, Pages 44482-44488

  Anderson, Patricia J ^a   Nesse, Anna ^c   Bock, Paul E ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL BONDS; CONFORMATIONS; ENZYMES; POLYPEPTIDES; SPECTROSCOPIC ANALYSIS;

BOND CLEAVAGE;

BIOCHEMISTRY;

6 CARBOXYFLUORESCEIN; ARGININE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; ENZYME PRECURSOR; HIRUDIN DERIVATIVE; HIRUDIN[54-65]; ISOLEUCINE; MEIZOTHROMBIN; PEPTIDE; PRETHROMBIN 1; PRETHROMBIN 2; PROTEIN; PROTHROMBIN; THREONINE; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME SUBSTRATE; HUMAN; MACROMOLECULE; NONHUMAN; PEPTIDE BOND CLEAVAGE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; SPECTROSCOPY;

ARGININE; BINDING SITES; ENZYME PRECURSORS; FACTOR XA; FLUORESCEINS; FLUORESCENT DYES; HIRUDINS; HUMANS; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTHROMBIN; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS; THREONINE; THROMBIN;

EID: 0242666308     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306917200     Document Type: Article

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