S-homoadenosyl-L-cysteine and S-homoadenosyl-L-homocysteine. Synthesis and binding studies of non-hydrolyzed substrate analogues with S-adenosyl-L-homocysteine hydrolase

Journal of Organic Chemistry

Volumn 67, Issue 23, 2002, Pages 8258-8260

  Miles, Robert W ^a   Nielsen, Lars P C ^a   Ewing, Gregory J ^a,b   Yin, Daniel ^c   Borchardt, Ronald T ^c   Robins, Morris J ^a  

^a Brigham Young University   (United States)

^b Biota Inc   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOPHILIC DISPLACEMENTS;

ADSORPTION; AMINES; AMINO ACIDS; SUBSTRATES;

SYNTHESIS (CHEMICAL);

6' CHLORO 6' DEOXYHOMOADENOSINE; ACETONITRILE; ADENINE DERIVATIVE; ADENOSINE DERIVATIVE; AMINO ACID; CHLORIDE; CYSTEINE DERIVATIVE; HOMOCYSTEINE; HYDROLASE; NUCLEOSIDE DERIVATIVE; PYRIDINE DERIVATIVE; S HOMOADENOSYLCYSTEINE; S HOMOADENOSYLHOMOCYSTEINE; SODIUM HYDROXIDE; UNCLASSIFIED DRUG; ADENOSYLHOMOCYSTEINASE; CYSTEINE; DRUG DERIVATIVE; ENZYME INHIBITOR; S ADENOSYLMETHIONINE; S HOMOADENOSYL L CYSTEINE; S HOMOADENOSYL L HOMOCYSTEINE; S-HOMOADENOSYL-L-CYSTEINE; S-HOMOADENOSYL-L-HOMOCYSTEINE;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; BINDING SITE; CHEMICAL BINDING; HYDROLYSIS; SYNTHESIS; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; KINETICS; METABOLISM; PLACENTA; PROTEIN BINDING;

ADENOSYLHOMOCYSTEINASE; CYSTEINE; ENZYME INHIBITORS; HOMOCYSTEINE; HUMANS; HYDROLASES; KINETICS; PLACENTA; PROTEIN BINDING; S-ADENOSYLMETHIONINE;

EID: 0037111688     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo020478g     Document Type: Article

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