Arsenite and its metabolites, MMAIII and DMAIII, modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice

Toxicology and Applied Pharmacology

Volumn 239, Issue 2, 2009, Pages 162-168

  Medina Diaz I M ^a   Estrada Muniz E ^b   Reyes Hernandez O D ^b   Ramirez P ^c   Vega, L ^b   Elizondo, G ^b  

^a UNIVERSIDAD AUTÓNOMA DE NAYARIT   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

CYP3A4; PXR; RXR alpha; Sodium arsenite; Transgenic mice; Ubiquitin proteasome pathway

Indexed keywords

ARSENIC TRIOXIDE; CACODYLIC ACID; CYTOCHROME P450 3A4; MESSENGER RNA; METHANEARSONIC ACID; PREGNANE X RECEPTOR; PROTEASOME; RETINOID X RECEPTOR ALPHA; UBIQUITIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME MODIFICATION; LIVER PARENCHYMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SMALL INTESTINE; TRANSGENIC MOUSE;

ANIMALS; ARSENITES; BLOTTING, WESTERN; CACODYLIC ACID; CYTOCHROME P-450 CYP3A; DUODENUM; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; ORGANOMETALLIC COMPOUNDS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, STEROID; RETINOID X RECEPTOR ALPHA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM COMPOUNDS; UBIQUITIN;

MUS MUSCULUS;

EID: 68949209308     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.11.009     Document Type: Article

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