Extracellular potassium dependency of block of heRG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation

Channels

Volumn 3, Issue 4, 2009, Pages 240-249

  Barrows, Brad ^a   Cheung, Krystin ^a   Bialobrzeski, Tim ^a   Foster, Jamison ^a   Schulze, John ^a   Miller, Alan ^a  

^a Touro University California   (United States)

Author keywords

Acquired long QT; Drug block; HERG; Inactivation; Permeation

Indexed keywords

CALCIUM ION; CESIUM ION; CISAPRIDE; POTASSIUM CHANNEL HERG; POTASSIUM ION; QUINIDINE; RUBIDIUM ION; TETRYLAMMONIUM;

ALCOHOLISM; ANIMAL CELL; ARTICLE; CHANNEL GATING; CLINICAL FEATURE; CONTROLLED STUDY; DIGESTIVE SYSTEM FUNCTION DISORDER; DIURETIC THERAPY; DRUG EFFECT; ELECTROLYTE BLOOD LEVEL; ENDOCRINE DISEASE; EXTRACELLULAR CALCIUM; HEART OUTPUT; HEART RATE; ION PERMEABILITY; ION TRANSPORT; KIDNEY DISEASE; LONG QT SYNDROME; MEMBRANE PERMEABILITY; NERVE BLOCK; NONHUMAN; QT PROLONGATION; SYMPATHETIC BLOCKING; TORSADE DES POINTES; VOLTAGE CLAMP;

EID: 68949181268     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.3.4.9254     Document Type: Article

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