Voltage-dependent blockade of HERG channels expressed in Xenopus oocytes by external Ca2+ and Mg2+

Journal of Physiology

Volumn 507, Issue 3, 1998, Pages 631-638

  Ho, Won Kyung ^a   Kim, Injune ^b   Lee, Chin O ^b   Earm, Yung E ^a  

^a Seoul National University   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; ION CHANNEL; MAGNESIUM ION; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DEPOLARIZATION; DISSOCIATION CONSTANT; HEART MUSCLE; HYPERPOLARIZATION; MICROELECTRODE; NONHUMAN; OOCYTE; POTASSIUM CELL LEVEL; POTASSIUM CURRENT; PRIORITY JOURNAL; REPOLARIZATION; VOLTAGE CLAMP; XENOPUS; BINDING SITE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION (PARAMETERS); EAG RELATED GENE; FEMALE; MEMBRANE CONDUCTANCE; PROTEIN EXPRESSION; RECEPTOR BLOCKING; VOLTAGE CLAMP TECHNIQUE;

ANIMALS; CALCIUM; CATION TRANSPORT PROTEINS; DNA-BINDING PROTEINS; ELECTRIC CONDUCTIVITY; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HUMANS; KINETICS; MAGNESIUM; MEMBRANE POTENTIALS; OOCYTES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RECOMBINANT PROTEINS; TIME FACTORS; TRANS-ACTIVATORS; XENOPUS LAEVIS;

EID: 0032521120     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.631bs.x     Document Type: Article

References (23)

1. ARELLANO, R. O., WOODWARD, R. M. & MILEDI, R. (1995). A monovalent cationic conductance that is blocked by extracellular divalent cations in Xenopus oocytes. Journal of Physiology 484, 593-604.
2. ARMSTRONG, C. M. & LOPEZ-BARNES, J. (1987). External calcium ions are required for potassium channel gating in squid neurons. Science 236, 712-714.
3. +]: A tale of two inactivation mechanisms. Neuron 15, 951-960.
4. FRANKENHAEUSER, B. & HODGKIN, A. L. (1957). The action of calcium on the electrical properties of squid axons. Journal of Physiology 137, 218-244.
5. GREEN, W. N. & ANDERSEN, O. S. (1991). Surface charges and ion channel function. Annual Review of Physiology 53, 341-359.
6. HILLE, B. (1992). Ionic Channels of Excitable Membranes. Sinauer Associate Inc., Sunderland, MA, USA.
7. 2+. Journal of Physiology 494, 727-742.
8. IRISAWA, H., BROWN, H. F. & GILES, W. (1993). Cardiac pacemaking in the sinoatrial node. Physiological Reviews 73, 197-227.
9. KIEHN, J., LACERDA, A. E., WIBLE, B. & BROWN, A. M. (1996). Molecular physiology and pharmacology of HERG: Single-channel current and block by dofetilide. Circulation 94, 2572-2579.
10. LOPATIN, A. N., MAKHINA, E. N. & NICHOLS, C. G. (1994). Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372, 366-369.
11. 2+ Nature 325, 156-159.
12. NOWAK, L., BREGESTOVSKI, R, ASCHER, P., HERBET, A. & PROCHIANTZ, A. (1984). Magnesium gates glutamate-activated channels in mouse central neurons. Nature 307, 462-465.
13. Kr potassium channel. Cell 81, 299-307.
14. SHIBASAKI, T. (1987). Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. Journal of Physiology 387, 227-250.
15. SMITH, P. L., BAUKROWITZ, T. & YELLEN, G. (1996). The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379, 833-836.
16. kr channel. Journal of General Physiology 107, 611-619.
17. SPIRES, S. & BEGENISICH, T. (1992). Chemical properties of the divalent cation binding site on potassium channels. Journal of General Physiology 100, 181-193.
18. SPIRES, S. & BEGENISICH, T. (1994). Modulation of potassium channel gating by external divalent cations. Journal of General Physiology 104, 675-692.
19. TRUDEAU, M. C., WARMKE, J. W., GANETZKY, B. & ROBERTSON, G. A. (1995). HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269, 92-95.
20. WANG, S., LIU, S., MORALES, M. J., STRAUSS, H. C. & RASMUSSON, R. L. (1997). A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. Journal of Physiology 502, 45-60.
21. WANG, S., MORALES, M. J., LIU, S., STRAUSS, H. C. & RASMUSSON, R. L. (1996). Time, voltage and ionic concentration dependence of rectification of h-erg expressed in Xenopus oocytes. FEBS Letters 389, 167-173.
22. WOODHULL, A. M. (1973). Ionic blockage of sodium channels in nerve. Journal of General Physiology 61, 687-708.
23. + current in cardiac cells. Circulation Research 80, 783-789.