Aging and cancer: Converging routes to disease prevention

Integrative Cancer Therapies

Volumn 8, Issue 2, 2009, Pages 115-122

  Chobotova, Katya ^a,b  

^a WOLFSON COLLEGE   (United Kingdom)

^b UNIVERSITI TEKNOLOGI MALAYSIA   (Malaysia)

Author keywords

Aging; Antioxidants; Caloric restriction; Cancer; Integrative; Oxidative stress; Physical activity; Psychological stress

Indexed keywords

AGING; ARTICLE; CALORIC RESTRICTION; CANCER PREVENTION; CANCER RESEARCH; DNA DAMAGE; ENERGY; HUMAN; MENTAL STRESS; NUTRIENT; NUTRITION; OXIDATIVE STRESS; PHYSICAL ACTIVITY; PHYSICAL STRESS; PRIORITY JOURNAL; SENSOR; STRESS MANAGEMENT; WELLBEING;

AGING; ANTIOXIDANTS; CALORIC RESTRICTION; DNA DAMAGE; HUMANS; NEOPLASMS; OXIDATIVE STRESS; STEM CELLS; STRESS, PSYCHOLOGICAL;

EID: 68949107868     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735409335505     Document Type: Article

References (89)

1. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008 ; 585: 325-337.
2. Sato N. Central role of mitochondria in metabolic regulation of liver pathophysiology. J Gastroenterol Hepatol. 2007 ; 22 (suppl 1). S1-S6.
3. Barja G. Free radicals and aging. Trends Neurosci. 2004 ; 27: 595-600.
4. Opresko PL, Fan J., Danzy S., Wilson DM 3rd, Bohr VA Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res. 2005 ; 33: 1230-1239.
5. Guillen MD, Goicoechea E. Toxic oxygenated alpha,beta-unsaturated aldehydes and their study in foods: a review. Crit Rev Food Sci Nutr. 2008 ; 48: 119-136.
6. Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2007 ; 2: 219-236.
7. Valko M., Leibfritz D., Moncol J., Cronin MT, Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007 ; 39: 44-84.
8. Levine AJ, Hu W., Feng Z. The P53 pathway: what questions remain to be explored? Cell Death Differ. 2006 ; 13: 1027-1036.
9. Janicke RU, Sohn D., Schulze-Osthoff K. The dark side of a tumor suppressor: anti-apoptotic p53. Cell Death Differ. 2008 ; 15: 959-976.
10. Liu B., Chen Y., St Clair DK ROS and p53: a versatile partnership. Free Radic Biol Med. 2008 ; 44: 1529-1535.
11. Bensaad K., Tsuruta A., Selak MA, et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell. 2006 ; 126: 107-120.
12. Bartosz G. Reactive oxygen species: destroyers or messengers? Biochem Pharmacol. 2009 ; 77: 1303-1315.
13. Vardatsikos G., Sahu A., Srivastava A. The insulin-like growth factor family: molecular mechanisms, redox regulation and clinical implications. Antioxid Redox Signal. 2009 ; 11: 1165-1190.
14. Liu L., Wise DR, Diehl JA, Simon MC Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem. 2008 ; 283: 31153-31162.
15. Martin GM Genetic modulation of senescent phenotypes in Homo sapiens. Cell. 2005 ; 120: 523-532.
16. Hakem R. DNA-damage repair; the good, the bad, and the ugly. EMBO J. 2008 ; 27: 589-605.
17. Campisi J. Aging, tumor suppression and cancer: high wire-act! Mech Ageing Dev. 2005 ; 126: 51-58.
18. Blasco MA Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet. 2005 ; 6: 611-622.
19. De Lange T. Telomere-related genome instability in cancer. Cold Spring Harb Symp Quant Biol. 2005 ; 70: 197-204.
20. Cawthon RM, Smith KR, O'Brien E., Sivatchenko A., Kerber RA Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003 ; 361: 393-395.
21. Ogami M., Ikura Y., Ohsawa M., et al. Telomere shortening in human coronary artery diseases. Arterioscler Thromb Vasc Biol. 2004 ; 24: 546-550.
22. Samani NJ, Boultby R., Butler R., Thompson JR, Goodall AH Telomere shortening in atherosclerosis. Lancet. 2001 ; 358: 472-473.
23. Serrano AL, Andres V. Telomeres and cardiovascular disease: does size matter? Circ Res. 2004 ; 94: 575-584.
24. Demissie S., Levy D., Benjamin EJ, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006 ; 5: 325-330.
25. Panossian LA, Porter VR, Valenzuela HF, et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging. 2003 ; 24: 77-84.
26. Epel ES, Blackburn EH, Lin J., et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004 ; 101: 17312-17315.
27. Valdes AM, Andrew T., Gardner JP, et al. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005 ; 366: 662-664.
28. von Zglinicki T., Martin-Ruiz CM Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med. 2005 ; 5: 197-203.
29. Greenberg RA, Rudolph KL Telomere structural dynamics in genome integrity control and carcinogenesis. Adv Exp Med Biol. 2005 ; 570: 311-341.
30. van Heemst D., den Reijer PM, Westendorp RG Ageing or cancer: a review on the role of caretakers and gatekeepers. Eur J Cancer. 2007 ; 43: 2144-2152.
31. Matheu A., Maraver A., Klatt P., et al. Delayed ageing through damage protection by the Arf/p53 pathway. Nature. 2007 ; 448: 375-379.
32. Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, Chumakov PM The antioxidant function of the p53 tumor suppressor. Nat Med. 2005 ; 11: 1306-1313.
33. Matheu A., Maraver A., Serrano M. The Arf/p53 pathway in cancer and aging. Cancer Res. 2008 ; 68: 6031-6034.
34. Gan L., Mucke L. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron. 2008 ; 58: 10-14.
35. Sasaki T., Maier B., Bartke A., Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell. 2006 ; 5: 413-422.
36. Cohen HY, Miller C., Bitterman KJ, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004 ; 305: 390-392.
37. Ungvari Z., Parrado-Fernandez C., Csiszar A., de Cabo R. Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res. 2008 ; 102: 519-528.
38. Fraga MF, Agrelo R., Esteller M. Cross-talk between aging and cancer: the epigenetic language. Ann NY Acad Sci. 2007 ; 1100: 60-74.
39. Taylor DM, Maxwell MM, Luthi-Carter R., Kazantsev AG Biological and potential therapeutic roles of sirtuin deacetylases. Cell Mol Life Sci. 2008 ; 65: 4000-4018.
40. Rossi DJ, Jamieson CH, Weissman IL Stems cells and the pathways to aging and cancer. Cell. 2008 ; 132: 681-696.
41. Denham M., Conley B., Olsson F., Cole TJ, Mollard R. Stem cells: an overview. Curr Protoc Cell Biol. 2005;Chapter 23:Unit 23.1.
42. Chambers SM, Shaw CA, Gatza C., Fisk CJ, Donehower LA, Goodell MA Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 2007 ; 5: e201.
43. Lombard DB, Chua KF, Mostoslavsky R., Franco S., Gostissa M., Alt FW DNA repair, genome stability, and aging. Cell. 2005 ; 120: 497-512.
44. Collado M., Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007 ; 130: 223-233.
45. Krtolica A., Campisi J. Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol. 2002 ; 34: 1401-1414.
46. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol. 2003 ; 38: 5-11.
47. Dean JP, Nelson PS Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis. Br J Cancer. 2008 ; 98: 245-249.
48. Blagosklonny MV Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells. Rejuvenation Res. 2008 ; 11: 801-808.
49. Devin JK, Young PP The effects of growth hormone and insulin-like growth factor-1 on the aging cardiovascular system and its progenitor cells. Curr Opin Investig Drugs. 2008 ; 9: 983-992.
50. Barbieri M., Gambardella A., Paolisso G., Varricchio M. Metabolic aspects of the extreme longevity. Exp Gerontol. 2008 ; 43: 74-78.
51. Chen YH, Lin SJ, Lin FY, et al. High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes. 2007 ; 56: 1559-1568.
52. McEwen BS Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging. 2002 ; 23: 921-939.
53. Irie M., Asami S., Ikeda M., Kasai H. Depressive state relates to female oxidative DNA damage via neutrophil activation. Biochem Biophys Res Commun. 2003 ; 311: 1014-1018.
54. McEwen BS Sleep deprivation as a neurobiologic and physiologic stressor: allostasis and allostatic load. Metabolism. 2006 ; 55 (10, suppl 2). S20-S23.
55. Dallman MF, Pecoraro N., Akana SF, et al. Chronic stress and obesity: a new view of "comfort food ". Proc Natl Acad Sci USA. 2003 ; 100: 11696-11701.
56. Godbout JP, Glaser R. Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. J Neuroimmune Pharmacol. 2006 ; 1: 421-427.
57. Tausk F., Elenkov I., Moynihan J. Psychoneuroimmunology. Dermatol Ther. 2008 ; 21: 22-31.
58. Sepa A., Ludvigsson J. Psychological stress and the risk of diabetes-related autoimmunity: a review article. Neuroimmunomodulation. 2006 ; 13: 301-308.
59. Blundell J., Kouser M., Powell CM Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation. Neurobiol Learn Mem. 2008 ; 90: 28-35.
60. Erabi K., Morinobu S., Kawano K., Tsuji S., Yamawaki S. Neonatal isolation changes the expression of IGF-IR and IGFBP-2 in the hippocampus in response to adulthood restraint stress. Int J Neuropsychopharmacol. 2007 ; 10: 369-381.
61. Thaker PH, Lutgendorf SK, Sood AK The neuroendocrine impact of chronic stress on cancer. Cell Cycle. 2007 ; 6: 430-433.
62. Lehto US, Ojanen M., Vakeva A., Aromaa A., Kellokumpu-Lehtinen P. Noncancer life stresses in newly diagnosed cancer. Support Care Cancer. 2008 ; 16: 1231-1241.
63. Weaver CM, Barnes S., Wyss JM, et al. Botanicals for age-related diseases: from field to practice. Am J Clin Nutr. 2008 ; 87: 493S-497S.
64. Maurer HR Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001 ; 58: 1234-1245.
65. Khan N., Mukhtar H. Multitargeted therapy of cancer by green tea polyphenols. Cancer Lett. 2008 ; 269: 269-280.
66. Kunnumakkara AB, Anand P., Aggarwal BB Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008 ; 269: 199-225.
67. Hayes JD, Kelleher MO, Eggleston IM The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Nutr. 2008 ; 47 (suppl 2). 73-88.
68. Prasad KN, Edwards-Prasad J., Kumar S., Meyers A. Vitamins regulate gene expression and induce differentiation and growth inhibition in cancer cells. Their relevance in cancer prevention. Arch Otolaryngol Head Neck Surg. 1993 ; 119: 1133-1140.
69. Thomas DR Vitamins in aging, health, and longevity. Clin Interv Aging. 2006 ; 1: 81-91.
70. Leifert WR, Abeywardena MY Cardioprotective actions of grape polyphenols. Nutr Res. 2008 ; 28: 729-737.
71. Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ Potential of resveratrol in anticancer and anti-inflammatory therapy. Nutr Rev. 2008 ; 66: 445-454.
72. Bonnefoy M., Drai J., Kostka T. [Antioxidants to slow aging, facts and perspectives]. Presse Med. 2002 ; 31: 1174-1184.
73. Yu BP, Kang CM, Han JS, Kim DS Can antioxidant supplementation slow the aging process? Biofactors. 1998 ; 7: 93-101.
74. Heydari AR, Unnikrishnan A., Lucente LV, Richardson A. Caloric restriction and genomic stability. Nucleic Acids Res. 2007 ; 35: 7485-7496.
75. Kritchevsky D. Caloric restriction and cancer. J Nutr Sci Vitaminol (Tokyo). 2001 ; 47: 13-19.
76. Suzuki M., Wilcox BJ, Wilcox CD Implications from and for food cultures for cardiovascular disease: longevity. Asia Pac J Clin Nutr. 2001 ; 10: 165-171.
77. Fair AM, Montgomery K. Energy balance, physical activity, and cancer risk. Methods Mol Biol. 2009 ; 472: 57-88.
78. Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996 ; 273: 59-63.
79. Cao SX, Dhahbi JM, Mote PL, Spindler SR Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci USA. 2001 ; 98: 10630-10635.
80. Kruk J. Physical activity in the prevention of the most frequent chronic diseases: an analysis of the recent evidence. Asian Pac J Cancer Prev. 2007 ; 8: 325-338.
81. Taaffe DR, Irie F., Masaki KH, et al. Physical activity, physical function, and incident dementia in elderly men: the Honolulu-Asia Aging Study. J Gerontol A Biol Sci Med Sci. 2008 ; 63: 529-535.
82. Yang Y., Verkuilen J., Rosengren KS, et al. Effects of a Taiji and Qigong intervention on the antibody response to influenza vaccine in older adults. Am J Chin Med. 2007 ; 35: 597-607.
83. Ko GT, Tsang PC, Chan HC A 10-week Tai-Chi program improved the blood pressure, lipid profile and SF-36 scores in Hong Kong Chinese women. Med Sci Monit. 2006 ; 12: CR196 - CR199.
84. Wayne PM, Krebs DE, Wolf SL, et al. Can Tai Chi improve vestibulopathic postural control? Arch Phys Med Rehabil. 2004 ; 85: 142-152.
85. Lee MS, Pittler MH, Ernst E. Is Tai Chi an effective adjunct in cancer care? A systematic review of controlled clinical trials. Support Care Cancer. 2007 ; 15: 597-601.
86. Mustian KM, Palesh OG, Flecksteiner SA Tai Chi Chuan for breast cancer survivors. Med Sport Sci. 2008 ; 52: 209-217.
87. Brown RP, Gerbarg PL Sudarshan Kriya Yogic breathing in the treatment of stress, anxiety, and depression. Part II - clinical applications and guidelines. J Altern Complement Med. 2005 ; 11: 711-717.
88. Kochupillai V., Kumar P., Singh D., et al. Effect of rhythmic breathing (Sudarshan Kriya and Pranayam) on immune functions and tobacco addiction. Ann NY Acad Sci. 2005 ; 1056: 242-252.
89. Arias AJ, Steinberg K., Banga A., Trestman RL Systematic review of the efficacy of meditation techniques as treatments for medical illness. J Altern Complement Med. 2006 ; 12: 817-832.