Bromelain: Biochemistry, pharmacology and medical use

Cellular and Molecular Life Sciences

Volumn 58, Issue 9, 2001, Pages 1234-1245

  Maurer, H R ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Antiinflammation; Bromelain; Complementary tumor therapy; Edema prevention and destruction; Fibrinolysis; Immunomodulation; Proteinases; Skin debridement; Thrombosis and metastasis prophylaxis

Indexed keywords

BROMELAIN;

DEBRIDEMENT; DRUG EFFECT; DRUG USE; EDEMA; FIBRINOLYSIS; FIBRINOLYTIC THERAPY; FRUIT; HUMAN; METASTASIS; NONHUMAN; REVIEW; THROMBOSIS;

ANANAS COMOSUS; ANGINA; ANIMALIA;

EID: 0034843751     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000936     Document Type: Review

References (87)

1. VIII. Bromelain
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3. Characterization and structure of pineapple stem inhibitor of cysteine proteinases
4. Solution structure of bromelain inhibitor VI from pineapple stem: Structural similarity with Bowman-Birk trypsin/chymotrypsin inhibitor from soybean
5. L-Pyroglutamyl-L-phenylalanyl-L-leucine-p-nitroanilide - A chromogenic substrate for thiol proteinase assay
6. Isolation and partial characterization of basic proteinases from stem bromelain
7. Isolation and characterization of two forms of an acidic bromelain stem proteinase
8. Purification and characterization of multiple forms of the pineapple stem derived cysteine proteinases ananain and comosain
9. Complete amino acid sequence of ananain and a comparison with bromelain and other plant cysteine proteases
10. Inactivation kinetics of enzyme pharmaceuticals in aqueous solutions
11. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application, an update
12. On the pharmacology of bromelain: An update with special regard to animal studies on dose-dependent effects
13. Bromelain: A literature review and discussion of its therapeutic application
14. Bromelain in der komple mentären tumortherapie Z
15. Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8 and Leu8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation
16. Bromelains - The pharmacology of the enzymes
17. Antiinfiammatory action of proteolytic enzymes administered orally compared with antiphlogistic compounds. I1
18. Die wirkung proteolytischer enzyme auf das posttraumatische syndrom
19. A double blind study of bromelain in the treatment of edema and ecchymoses following surgical and non-surgical trauma to the face
20. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain
21. Die resorption von tetrazyklin in gegenwart von bromelain bei oraler applikation
22. Effect of bromelain on serum and tissue levels of amoxycillin
23. Tetracyclin-konzentration im prostata-sekret. Z. antimikrob, antineoplast
24. A plant protease for potentiation of and possible replacement of antibiotics
25. A double- blind clinical evaluation of bromelain in the treatment of acute sinusitis
26. Bromelain: Antiinflammatory and serum fibrinolytic activity after oral administration in the rat
27. Effect of bromelain on fibrinogen level, prothrombin complex and platelet aggregation in the rat - A preliminary report
28. Chromatographic fractionation and characterization of the active platelet aggregation inhibitory factor from bromelain
29. Effect of bromelain on human platelet aggregation
30. Isolation of a fibrinolysis enzyme activator from commercial bromelain
31. Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo
32. Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from breast cancer patients
33. 2-macroglobulin
34. Oral bioavailability of proteolytic enzymes
35. Effects of bromelain antiedema therapy on coagulation, bleeding and prothrombin times
36. Bromelain interaction with some protease inhibitors and rabbit specific antiserum
37. Bromelain, a thiolprotease from pineapple stem, depletes high molecular weight kininogen by activation of Hageman factor
38. Effect of bromelain on kaolin - Incluced inflammation in rats
39. Possible involvement of eicosanoids in the pharmacological action of bromelain
40. Therapeutique anti-cancereuse et bromelaine
41. Bromelain in der kontrolle malignen wachstums
42. Inhibition of tumor growth in vitro by bromelain, an extract of the pineapple (Ananas comosus)
43. Bromelain proteinase F9 augments human lymphocyte-mediated growth inhibition of various tumor cells in vitro
44. Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells
45. Bromelain induces the differentiation of leukemic cells in vitro: An explanation for its cytostatic effects?
46. Thrombosis and cancer
47. Venous thromboembolism and cancer
48. The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism
49. Potential role of platelets in the pathogenesis of tumor metastasis
50. Platelet contribution to the formation of metastatic foci: The role of cancer cell-induced platelet activation
51. Platelets and cancer metastasis: More than an epiphenomenon
52. The effect of platelets on invasiveness and protease production of human mammary tumor cells
53. Progress in anti-invasion and anti-metastasis research and treatment
54. Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity
55. Bromelain proteinases modulate the CD44 expression on human Molt4/8 leukemia and SK-Mel 28 melanoma cells in vitro
56. Proteolytic enzymes modulate the adhesion molecule CD44 on malignant cells in vitro
57. CD44 as a marker in human cancers
58. Bromelain protease F9 reduces the CD44 mediated adhesion of human peripheral blood lymphocytes to human umbilical vein endothelial cells
59. Selective modulation of cell adhesion molecules on lymphocytes by bromelain proteases
60. Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes
61. Proteolytic enzymes and amylase in human peripheral blood mononuclear cells in vitro
62. Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations
63. Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation
64. Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells
65. Isolation of an effective debriding agent from the stems of pineapple plants
66. Enzymatic frostbite eschar debridement by bromelain
67. Die resorption eines proteolytischen proteins pflanzlichen ursprungs aus dem Magen-Darm-Trakt in das blut und in die lymphe von erwachsenen ratten
68. Intestinal absorption of undegraded bromelain in humans
69. Antihypertensive wirkung oraler therapie mit kallikrein
70. Oral cytokine administration
71. Bioavailability of therapeutically used hydrolytic enzymes
72. Oral bioavailability of bromelain and trypsin after repeated oral administration of a commercial polyenzyme preparation
73. On the bioavailability of bromelain containing in two different formulas after multiple oral dosage
74. Dose-related bioavailability of bromelain and trypsin after repeated oral administration
75. Dose-related bioavailability of bromelain and trypsin after repeated oral administration
76. Sperimentazione clinica in doppio cieco delle bromelina in pazienti con fratture recenti degli arti inferiori
77. Behandlung posttraumatischer entzündungsund schwellungszustände
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79. Bromelain therapy for the prevention of episiotomy pain
80. A double-blind crossover-study of plant proteolytic enzyme in oral surgery
81. Stellungnahme zur kritik an enzympräparaten
82. Mechanosensors in plants
83. Signal transduction in the carnivorous plant Sarracenia purpurea