Amiloride derivatives induce apoptosis by depleting ER Ca2+ stores in vascular endothelial cells

British Journal of Pharmacology

Volumn 156, Issue 8, 2009, Pages 1296-1304

  Park, K S ^b,c   Poburko, D ^b   Wollheim, C B ^b   Demaurex, N ^a,b  

^a Nicolas Demaurex ^*  (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c Yonsei University Wonju College of Medicine   (South Korea)

Author keywords

Amiloride derivatives; D1ER; ER calcium depletion; ER stress; Na + H+ exchanger

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 5 (N ETHYL N ISOPROPYL)AMILORIDE; 5 (N ISOBUTYL N METHYL)AMILORIDE; 5 (N,N HEXAMETHYLENE)AMILORIDE; AMILORIDE; AMILORIDE DERIVATIVE; CALCIUM ION; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; THAPSIGARGIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CELL PH; CELL STRESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; HEART PROTECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; REPERFUSION INJURY; SARCOPLASMIC RETICULUM; VASCULAR ENDOTHELIUM;

AMILORIDE; ANTIGENS, DIFFERENTIATION; APOPTOSIS; CALCIUM; CELL CYCLE PROTEINS; DIURETICS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GUANIDINES; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-HYDROGEN ANTIPORTER; SULFONES; THAPSIGARGIN; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION, GENETIC;

EID: 68749095178     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00133.x     Document Type: Article

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