Reduced infarct size in the rabbit heart in vivo by ethylisopropyl-amiloride. A role for Na+/H+ exchange

Basic Research in Cardiology

Volumn 91, Issue 3, 1996, Pages 203-209

  Bugge, E ^a   Munch Ellingsen, J ^a   Ytrehus, K ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Anesthetized rabbit; EIPA; Infarct size; Na+ H+ exchange; TTC

Indexed keywords

5 (N ETHYL N ISOPROPYL)AMILORIDE; PROTON; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NONHUMAN; PROTON SODIUM EXCHANGE; RABBIT;

AMILORIDE; ANALYSIS OF VARIANCE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; FEMALE; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL INFARCTION; RABBITS; SODIUM-HYDROGEN ANTIPORTER;

EID: 0029999419     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00788906     Document Type: Article

References (39)

1. Anderson SE, Murphy E, Steenbergen C, London RE, Cala PM (1990) Na/H exchange in myocardium: Effects of hypoxia and acidification on Na and Ca. Am J Physiol 259: C940-C948
2. Bugge E, Ytrehus K (1995) Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart - a protective additive to ischaemic preconditioning. Cardiovasc Res 29: 269-274
3. Burmeister WE, Reynolds RD, Lee RJ (1981) Limitation of myocardial infarct size by atenolol, nadolol and propranolol in dogs. Eur J Pharmacol 75: 7-10
4. + exchange. Circ Res 66: 1156-1159
5. Duan J, Karmazyn M (1992) Protective effects of amiloride on the ischemic reperfused rat heart. Relation to mitochondrial function. Eur J Pharmacol 210: 149-157
6. Duff HJ, Brown E, Cragoe EJ, Rahmberg M (1991) Antiarrhythmic activity of amiloride: Mechanisms. J Cardiovasc Pharmacol 17: 879-888
7. + concentration. J Biol Chem 259: 8880-8885
8. Gold MR, Stricharz GR (1991) Use-dependent block of atrial sodium current by ethylisopropylamiloride. J Cardiovasc Pharmacol 17: 792-799
9. 2 and their membrane substrates. Trends Cardiovasc Med 2: 115-121
10. 2 contributes to loss of plasma membrane integrity during chemical hypoxia in rat hepatocytes. Biochem Biophys Res Com 174: 654-659
11. 2+ overload in isolated perfused rabbit heart. Circulation 89: 2787-2798
12. Jennings RB, Reimer KA, Steenbergen C (1986) Myocardial ischemia revisited: The osmolar load, membrane damage, and reperfusion. J Mol Cell Cardiol 18: 769-780
13. + exchange. Am J Physiol 255: H608-H615
14. Karmazyn M (1991) The 1990 Merck Frosst Award. Ischemic and reperfusion injury in the heart. Cellular mechanisms and pharmacological interventions. Can J Physiol Pharmacol 69: 719-730
15. + exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox. Cardiovasc Res 27: 915-924
16. + exchange inhibitors against cardiac injury produced by ischemia/reperfusion, hypoxia/reoxygenation, and the calcium paradox. J Cardiovasc Pharmacol 21: 172-178
17. + exchange inhibition in ischemic, reperfused porcine hearts. Circulation 92: 912-917
18. Kleyman TR, Cragoe EJ (1988) Amiloride and its analogs as tools in the study of ion transport. J Membrane Biol 105: 1-21
19. Kloner RA, Braunwald E (1987) Effects of calcium antagonists on infarcting myocardium. Am J Cardiol 59: 84B-94B
20. Lazdunski M, Frelin C, Vigne P (1985) The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 17: 1029-1042
21. 1 Adenosine receptors in rabbit heart. Circulation 84: 350-356
22. Meng H-P, Lonsberry BB, Pierce GN (1991) Influence of perfusate pH on the postischemic recovery of cardiac contractile function: Involvement of sodium-hydrogen exchange. J Pharmacol Exp Ther 258: 772-777
23. Meng H-P, Pierce GN (1990) Protective effects of 5′-(N,N-dimethyl)amiloride on ischemia-reperfusion injury in hearts. Am J Physiol 258: H1615-H1619
24. Moffat MP, Karmazyn M (1993) Protective effect of the potent Na/H exchange inhibitor methylisobutyl amiloride against postischemic contractile dysfunction in rat and guinea-pig hearts. J Mol Cell Cardiol 25: 959-971
25. Otani H, Engelman RM, Rousou JA, Breyer RH, Das DK (1986) Enhanced prostaglandin synthesis due to phospholipid breakdown in ischemic-reperfused myocardium. J Mol Cell Cardiol 18: 953-961
26. Pierce GN, Cole WC, Liu K, Massaeli H, Maddaford TG, Chen YJ, McPherson CD, Jain S, Sontag D (1993) Modulation of cardiac performance by amiloride and several selected derivatives of amiloride. J Pharmacol Exp Ther 265: 1280-1291
27. Piwnica-Worms D, Jacob R, Horres R, Lieberman M (1985) Na/H exchange in cultured chick heart cells. pHi regulation. J Gen Physiol 85: 43-64
28. Piwnica-Worms D, Jacob R, Shigeto N, Horres R, Lieberman M (1986) Na/H exchange in cultured chick heart cells: Secondary stimulation of electrogenic transport during recovery from intracellular acidosis. J Mol Cell Cardiol 18: 1109-1116
29. Regan TJ, Broisman L, Haider B, Eaddy C, Oldewurtel HA (1980) Dissociation of myocardial sodium and potassium alterations in mild versus severe ischemia. Am J Physiol 238: H575-H580
30. + antiporter inhibitor on postischemic reperfusion in pig heart. J Cardiovasc Pharmacol 23: 72-78
31. + exchange inhibitors in cardiac ischemia. J Mol Cell Cardiol 24: 731-740
32. Siffert W (1995) Regulation of platelet function by sodium-hydrogen exchange. Cardiovasc Res 29: 160-166
33. 2+ exchange. Circ Res 65: 1045-1056
34. van den Bosch H (1980) Intracellular phospholipases A. Biochimica et Biophysica Acta 604: 191-246
35. + exchange system in various cell types. Biochem Biophys Res Com 116: 86-90
36. +-exchange system. Mol Pharm 25: 131-136
37. Yan G-X, Kléber AG (1992) Changes in extracellular and intracellular pH in ischemic rabbit papillary muscle. Circ Res 71: 460-470
38. + exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. Am J Physiol 267: H2430-H2440
39. Ytrehus K, Downey JM (1993) Experimental models assessing the physiology of myocardial ischemia. Curr Opin Cardiol 8: 581-588