The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 65, Issue 8, 2009, Pages 762-766

  Cody, Vivian ^a,b   Pace, Jim ^a   Lin, Lu ^c   Gangjee, Aleem ^c  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c DUQUESNE UNIVERSITY   (United States)

Author keywords

2,4 diaminofuro 2,3 d pyrimidine antifolate; Human dihydrofolate reductase

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; PYRIMIDINE DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; HUMAN; ISOMERISM; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID ANTAGONISTS; HUMANS; ISOMERISM; MODELS, MOLECULAR; PROTEIN CONFORMATION; PYRIMIDINES; RECOMBINANT PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 68649109825     PISSN: 17443091     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309109025548     Document Type: Article

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