Selective Pneumocystis carinii dihydrofolate reductase inhibitors: Design, synthesis, and biological evaluation of new 2,4-diamino-5- substituted-furo[2,3-d]pyrimidines

Journal of Medicinal Chemistry

Volumn 41, Issue 8, 1998, Pages 1263-1271

  Gangjee, Aleem ^a   Guo, Xin ^a   Queener, Sherry F ^b   Cody, Vivian ^c   Galitsky, Nikolai ^c   Luft, Joe R ^c   Pangborn, Walter ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 [(2' NAPHTHYLTHIO)METHYL]FURO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [(2' PHENYLANILINO)METHYL]FURO[2,3 D]PYRIMIDINE; ANTIPROTOZOAL AGENT; DIHYDROFOLATE REDUCTASE INHIBITOR; EPIROPRIM; PYRIMIDINE DERIVATIVE; TRIMETHOPRIM; TRIMETREXATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LIVER; NONHUMAN; PNEUMOCYSTIS CARINII; RAT; STRUCTURE ACTIVITY RELATION; TOXOPLASMA GONDII;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FOLIC ACID ANTAGONISTS; LIVER; MODELS, MOLECULAR; NAD; NAPHTHALENES; PHENYLALANINE; PNEUMOCYSTIS; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA;

EID: 0032499289     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970537w     Document Type: Article

References (26)

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