Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 4, 1996, Pages 593-602

  Kuyper, Lee F ^a   Garvey, Janice M ^a   Baccanari, David P ^a   Champness, John N ^b   Stammers, David K ^b   Beddell, Christopher R ^b  

^a GLAXOSMITHKLINE   (United States)

^b WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; ANIMALIA; GALLUS GALLUS; NEISSERIA GONORRHOEAE; PLASMODIUM BERGHEI; STAPHYLOCOCCUS AUREUS;

2 AMINO 4 METHYL 3 (3,4,5 TRIMETHOXYPHENYL) 7H PYRROLO[2,3 D] PYRIMIDINE; ANTIINFECTIVE AGENT; DIHYDROFOLATE REDUCTASE; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; CHICKEN; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; ESCHERICHIA COLI; LIVER; NEISSERIA GONORRHOEAE; NONHUMAN; PLASMODIUM BERGHEI; RAT; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-INFECTIVE AGENTS, URINARY; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; HUMANS; HYDROGEN BONDING; LIVER; MOLECULAR CONFORMATION; NEISSERIA GONORRHOEAE; PLASMODIUM BERGHEI; RATS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIMETHOPRIM;

EID: 0030012880     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00045-4     Document Type: Article

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