Mass spectrometric investigation of molecular variability of grass pollen group 1 allergens

Journal of Proteome Research

Volumn 8, Issue 8, 2009, Pages 4014-4027

  Fenaille, François ^a   Nony, Emmanuel ^b   Chabre, Henri ^b   Lautrette, Aurélie ^b   Couret, Marie Noëlle ^b   Batard, Thierry ^b   Moingeon, Philippe ^b   Ezan, Eric ^a  

^a SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^b Stallergenes SA   (France)

Author keywords

Amino acid sequence; ESI Orbitrap; Group 1 grass pollen allergens; MALDI TOF; N and O glycosylation; Post translational modifications; Proline hydroxylation; Species specific peptides

Indexed keywords

GLYCOPEPTIDE; HYDROXYPROLINE; POLLEN ANTIGEN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DEAMINATION; ENZYME METABOLISM; GRASS POLLEN; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; SPECIES DIFFERENCE;

ALLERGENS; AMINO ACID SEQUENCE; CHROMATOGRAPHY, LIQUID; GLYCOSYLATION; HYDROXYLATION; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PLANT PROTEINS; POACEAE; POLLEN; PROTEIN PROCESSING, POST-TRANSLATIONAL; SPECIES SPECIFICITY;

POA;

EID: 68549089151     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr900359p     Document Type: Article

References (55)

1. Andersson, K.; Lidholm, J. Characteristics and immunobiology of grass pollen allergens. Int. Arch. Allergy Immunol. 2003, 130 (2), 87-107.
2. Mohapatra, S. S.; Lockey, R. F.; Shirley, S. Immunobiology of grass pollen allergens. Curr. Allergy Asthma Rep. 2005, 5 (5), 381-387.
3. Altmann, F. The role of protein glycosylation in allergy. Int. Arch. Allergy Immunol. 2007, 142 (2), 99-115.
4. Chardin, H.; Senechal, H.; Wal, J. M.; Desvaux, F. X.; Godfrin, D.; Peltre, G. Characterization of peptidic and carbohydrate cros-sreactive determinants in pollen polysensitization. Clin. Exp. Allergy 2008, 38 (4), 680-685.
5. Moingeon, P.; Hrabina, M.; Bergmann, K. C.; Jaeger, S.; Frati, F.; Bordas, V.; Peltre, G. Specific immunotherapy for common grass pollen allergies: pertinence of a five grass pollen vaccine. Int. Arch. Allergy Immunol. 2008, 146 (4), 338-342.
6. van Oort, E.; de Heer, P. G.; Dieker, M.; van Leeuwen, A. W.; Aalberse, R. C.; van Ree, R. Characterization of natural Dac g 1 variants: an alternative to recombinant group 1 allergens. J. Allergy Clin. Immunol. 2004, 114 (5), 1124-1130.
7. Petersen, A.; Grobe, K.; Lindner, B.; Schlaak, M.; Becker, W. M. Comparison of natural and recombinant isoforms of grass pollen allergens. Electrophoresis 1997, 18 (5), 819-825.
8. Petersen, A.; Becker, W. M.; Schlaak, M. Characterization of grass group I allergens in timothy grass pollen. J. Allergy Clin. Immunol. 1993, 92 (6), 789-796.
9. Griffith, I. J.; Smith, P. M.; Pollock, J.; Theerakulpisut, P.; Avjioglu, A.; Davies, S.; Hough, T.; Singh, M. B.; Simpson, R. J.; Ward, L. D. Cloning and sequencing of Lol pI, the major allergenic protein of rye-grass pollen. FEBS Lett. 1991, 279 (2), 210-215.
10. Petersen, A.; Schramm, G.; Bufe, A.; Schlaak, M.; Becker, W. M. Structural investigations of the major allergen Phl p I on the complementary DNA and protein level. J. Allergy Clin. Immunol. 1995, 95 (5), 987-994.
11. Corti, V.; Cattaneo, A.; Bachi, A.; Rossi, R. E.; Monasterolo, G.; Paolucci, C.; Burastero, S. E.; Alessio, M. Identification of grass pollen allergens by two-dimensional gel electrophoresis and serological screening. Proteomics 2005, 5 (3), 729-736.
12. Iraneta, S. G.; Acosta, D. M.; Duran, R.; Apicella, C.; Orlando, U. D.; Seoane, M. A.; Alonso, A.; Duschak, V. G. MALDI-TOF MS analysis of labile Lolium perenne major allergens in mixes. Clin. Exp. Allergy 2008, 38 (8), 1391-1399.
13. van Oort, E.; de Heer, P. G.; Dieker, M.; van Leeuwen, A. W.; Aalberse, R. C.; van Ree, R. Characterization of natural Dac g 1 variants: an alternative to recombinant group 1 allergens. J. Allergy Clin. Immunol. 2004, 114 (5), 1124-1130.
14. van Oort, E.; de Heer, P. G.; Dieker, M.; van Leeuwen, A. W.; Aalberse, R. C.; van Ree, R. Characterization of natural Dac g 1 variants: an alternative to recombinant group 1 allergens. J. Allergy Clin. Immunol 2004, 114 (5), 1124-1130.
15. Wicklein, D.; Lindner, B.; Moll, H.; Kolarich, D.; Altmann, F.; Becker, W. M.; Petersen, A. Carbohydrate moieties can induce mediator release: a detailed characterization of two major timothy grass pollen allergens. Biol. Chem. 2004, 385 (5), 397-407.
16. Wilson, I. B.; Altmann, F. Structural analysis of N-glycans from allergenic grass, ragweed and tree pollens: core alpha1,3-linked fucose and xylose present in all pollens examined. Glycoconjugate J. 1998, 15 (11), 1055-1070.
17. van Ree, R.; Cabanes-Macheteau, M.; Akkerdaas, J.; Milazzo, J. P.; Loutelier-Bourhis, C.; Rayon, C.; Villalba, M.; Koppelman, S.; Aalberse, R.; Rodriguez, R.; Faye, L.; Lerouge, P. Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens. J. Biol. Chem. 2000, 275 (15), 11451-11458.
18. Leonard, R.; Petersen, B. O.; Himly, M.; Kaar, W.; Wopfner, N.; Kolarich, D.; van, Ree, R.; Ebner, C.; Duus, J. O.; Ferreira, F.; Altmann, F. Two novel types of O-glycans on the mugwort pollen allergen Art v 1 and their role in antibody binding. J. Biol. Chem. 2005, 280 (9), 7932-7940.
19. Petersen, A.; Schramm, G.; Schlaak, M.; Becker, W. M. Posttranslational modifications influence IgE reactivity to the major allergen Phl p 1 of timothy grass pollen. Clin. Exp. Allergy 1998, 28 (3), 315-321.
20. Esch, R. E. Allergen source materials and quality control of allergenic extracts. Methods 1997, 13 (1), 2-13.
21. Hermeling, S.; Aranha, L.; Damen, J. M.; Slijper, M.; Schellekens, H.; Crommelin, D. J.; Jiskoot, W. Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b. Pharm. Res. 2005, 22 (12), 1997-2006.
22. Houde, D.; Kauppinen, P.; Mhatre, R.; Lyubarskaya, Y. Determination of protein oxidation by mass spectrometry and method transfer to quality control. J. Chromatogr., A 2006, 1123 (2), 189-198.
23. Cohen, S. L.; Price, C.; Vlasak, J. Beta-elimination and peptide bond hydrolysis: two distinct mechanisms of human IgG1 hinge fragmentation upon storage. J. Am. Chem. Soc. 2007, 129 (22), 6976-6977.
24. Fenaille, F.; Groseil, C.; Ramon, C.; Riande, S.; Siret, L.; Chtourou, S.; Bihoreau, N. Mass spectrometric characterization of N- and O-glycans of plasma-derived coagulation factor VII. Glycoconjugate J. 2008, 25 (9), 827-842.
25. Gadgil, H. S.; Bondarenko, P. V.; Pipes, G.; Rehder, D.; McAuley, A.; Perico, N.; Dillon, T.; Ricci, M.; Treuheit, M. The LC/MS analysis of glycation of IgG molecules in sucrose containing formulations. J. Pharm. Sci. 2007, 96 (10), 2607-2621.
26. Domon, B.; Aebersold, R. Mass spectrometry and protein analysis. Science 2006, 312 (5771), 212-217.
27. Srebalus Barnes, C. A.; Lim, A. Applications of mass spectrometry for the structural characterization of recombinant protein pharmaceuticals. Mass Spectrom. Rev. 2007, 26 (3), 370-388.
28. Helsper, J. P.; Gilissen, L. J.; van Ree, R.; America, A. H.; Cordewener, J. H.; Bosch, D. Quadrupole time-of-flight mass spectrometry: a method to study the actual expression of allergen isoforms identified by PCR cloning. J. Allergy Clin. Immunol. 2002, 110 (1), 131-138.
29. Yu, Y. Q.; Gilar, M.; Lee, P. J.; Bouvier, E. S.; Gebler, J. C. Enzyme-friendly, mass spectrometry-compatible surfactant for in-solution enzymatic digestion of proteins. Anal. Chem. 2003, 75 (21), 6023-6028.
30. Thaysen-Andersen, M.; Thogersen, I. B.; Nielsen, H. J.; Lademann, U.; Brunner, N.; Enghild, J. J.; Hojrup, P. Rapid and individual-specific glycoprofiling of the low abundance N-glycosylated protein tissue inhibitor of metalloproteinases-1. Mol. Cell. Proteomics 2007, 6 (4), 638-647.
31. Duriez, E.; Fenaille, F.; Tabet, J. C.; Lamourette, P.; Hilaire, D.; Becher, F.; Ezan, E. Detection of ricin in complex samples by immunocapture and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Proteome Res. 2008, 7 (9), 4154-4163.
32. Frank, A.; Pevzner, P. PepNovo: de novo peptide sequencing via probabilistic network modeling. Anal. Chem. 2005, 77 (4), 964-973.
33. Frank, A. M.; Savitski, M. M.; Nielsen, M. L.; Zubarev, R. A.; Pevzner, P. A. De novo peptide sequencing and identification with precision mass spectrometry. J. Proteome Res. 2007, 6 (1), 114-123.
34. van Oort, E.; de Heer, P. G.; Dieker, M.; van Leeuwen, A. W.; Aalberse, R. C.; van Ree, R. Characterization of natural Dac g 1 variants: an alternative to recombinant group 1 allergens. J. Allergy Clin. Immunol. 2004, 114 (5), 1124-1130.
35. Carrera, M.; Canas, B.; Pineiro, C.; Vazquez, J.; Gallardo, J. M. De novo mass spectrometry sequencing and characterization of species-specific peptides from nucleoside diphosphate kinase B for the classification of commercial fish species belonging to the family Merlucciidae. J. Proteome Res. 2007, 6 (8), 3070-3080.
36. Selles-Marchart, S.; Luque, I.; Casado-Vela, J.; Martinez-Esteso, M. J.; Bru-Martinez, R. Proteomics of multigenic families from species underrepresented in databases: the case of loquat (Eriobotrya japonica Lindl.) polyphenol oxidases. J. Proteome Res. 2008, 7 (9), 4095-4106.
37. Zubarev, R.; Mann, M. On the proper use of mass accuracy in proteomics. Mol. Cell. Proteomics 2007, 6 (3), 377-381.
38. Mann, M.; Kelleher, N. L. Precision proteomics: the case for high resolution and high mass accuracy. Proc. Natl. Acad. Sci. U.S.A. 2008, 105 (47), 18132-18138.
39. van Ree, R.; van Leeuwen, W. A.; Aalberse, R. C. How far can we simplify in vitro diagnostics for grass pollen allergy?: A study with 17 whole pollen extracts and purified natural and recombinant major allergens. J. Allergy Clin. Immunol. 1998, 102 (2), 184-190.
40. Pan, S.; Aebersold, R.; Chen, R.; Rush, J.; Goodlett, D. R.; McIntosh, M. W.; Zhang, J.; Brentnall, T. A. Mass spectrometry based targeted protein quantification: Methods and applications. J. Proteome Res. 2009, 8 (2), 787-797.
41. Fusaro, V. A.; Mani, D. R.; Mesirov, J. P.; Carr, S. A. Prediction of high-responding peptides for targeted protein assays by mass spectrometry. Nat. Biotechnol. 2009, 27 (2), 191-198.
42. Yen, C. Y.; Russell, S.; Mendoza, A. M.; Meyer-Arendt, K.; Sun, S.; Cios, K. J.; Ahn, N. G.; Resing, K. A. Improving sensitivity in shotgun proteomics using a peptide-centric database with reduced complexity: protease cleavage and SCX elution rules from data mining of MS/MS spectra. Anal. Chem. 2006, 78 (4), 1071-1084.
43. Rodriguez, J.; Gupta, N.; Smith, R. D.; Pevzner, P. A. Does trypsin cut before proline?:. J. Proteome Res. 2008, 7 (1), 300-305.
44. Barnidge, D. R.; Hall, G. D.; Stocker, J. L.; Muddiman, D. C. Evaluation of a cleavable stable isotope labeled synthetic peptide for absolute protein quantification using LC-MS/MS. J. Proteome Res 2004, 3 (3), 658-661.
45. Krokhin, O. V.; Antonovici, M.; Ens, W.; Wilkins, J. A.; Standing, K. G. Deamidation of -Asn-Gly- sequences during sample preparation for proteomics: Consequences for MALDI and HPLC-MALDI analysis. Anal. Chem. 2006, 78 (18), 6645-6650.
46. Gaza-Bulseco, G.; Li, B.; Bulseco, A.; Liu, H. Method to differentiate Asn deamidation that occurred prior to and during sample preparation of a monoclonal antibody. Anal. Chem. 2008, 80 (24), 9491-9498.
47. Swiderek, K. M.; Davis, M. T.; Lee, T. D. The identification of peptide modifications derived from gel-separated proteins using electrospray triple quadrupole and ion trap analyses. Electrophoresis 1998, 19 (6), 989-997.
48. Lapolla, A.; Fedele, D.; Reitano, R.; Arico, N. C.; Seraglia, R.; Traldi, P.; Marotta, E.; Tonani, R. Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides. J. Am. Soc. Mass Spectrom. 2004, 15 (4), 496-509.
49. Fenaille, F.; Morgan, F.; Parisod, V.; Tabet, J. C.; Guy, P. A. Solid-state glycation of beta-lactoglobulin by lactose and galactose: localization of the modified amino acids using mass spectrometric techniques. J. Mass Spectrom. 2004, 39 (1), 16-28.
50. Zhang, Q.; Ames, J. M.; Smith, R. D.; Baynes, J. W.; Metz, T. O. A Perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease. J. Proteome Res. 2009, 8 (2), 754-769.
51. Wuhrer, M.; Catalina, M. I.; Deelder, A. M.; Hokke, C. H. Glycoproteomics based on tandem mass spectrometry of glycopeptides. J. Chromatogr., B 2007, 849 (1-2), 115-128.
52. Macek, B.; Hofsteenge, J.; Peter-Katalinic, J. Direct determination of glycosylation sites in O-fucosylated glycopeptides using nanoelectrospray quadrupole time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2001, 15 (10), 771-777.
53. Dalpathado, D. S.; Desaire, H. Glycopeptide analysis by mass spectrometry. Analyst 2008, 133 (6), 731-738.
54. Hagglund, P.; Bunkenborg, J.; Elortza, F.; Jensen, O. N.; Roepstorff, P. A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation. J. Proteome Res. 2004, 3 (3), 556-566.
55. Kieliszewski, M. J.; O'Neill, M.; Leykam, J.; Orlando, R. Tandem mass spectrometry and structural elucidation of glycopeptides from a hydroxyproline-rich plant cell wall glycoprotein indicate that contiguous hydroxyproline residues are the major sites of hydroxyproline O-arabinosylation. J. Biol. Chem. 1995, 270 (6), 2541-2549.