New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5101-5104

  Bharate, Sandip B ^a   Guo, Lilu ^b   Reeves, Tony E ^c   Cerasoli, Douglas M ^c   Thompson, Charles M ^a,b  

^a UNIVERSITY OF MONTANA   (United States)

^b ATERIS Technologies LLC   (United States)

^c USAMRICD   (United States)

Author keywords

2 PAM; Acetylcholinesterase; Monoquaternary pyridinium oximes; Organophosphorus; Pralidoxime; Reactivators

Indexed keywords

ACETIC ACID DERIVATIVE; ACETYLCHOLINESTERASE; FURAN DERIVATIVE; HETEROCYCLIC COMPOUND; ISOXAZOLE DERIVATIVE; MONOQUATERNARY PYRIDINIUM OXIME DERIVATIVE; OXIME DERIVATIVE; PARAOXON; PRALIDOXIME IODIDE; RECOMBINANT ENZYME; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; EEL; ENZYME INHIBITION; ENZYME REACTIVATION; HUMAN; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; ELECTROPHORUS; HUMANS; OXIMES; PARAOXON; PRALIDOXIME COMPOUNDS; RECOMBINANT PROTEINS;

ELECTROPHORUS ELECTRICUS;

EID: 68349144417     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.035     Document Type: Article

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