Negative Regulation of the EGFR-MAPK Cascade by Actin-MAL-Mediated Mig6/Errfi-1 Induction

Molecular Cell

Volumn 35, Issue 3, 2009, Pages 291-304

  Descot, Arnaud ^a   Hoffmann, Reinhard ^b   Shaposhnikov, Dmitry ^a   Reschke, Markus ^a   Ullrich, Axel ^a   Posern, Guido ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

CELLBIO; DNA; SIGNALING

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; G ACTIN; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MYOCARDIN RELATED TRANSCRIPTION FACTOR A; SERUM RESPONSE FACTOR; SPHINGOSINE 1 PHOSPHATE; TRANSCRIPTION FACTOR; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MIG6 GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C FOS; REGULATOR GENE; SIGNAL TRANSDUCTION; UPREGULATION;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; CELL PROLIFERATION; CYCLOHEXIMIDE; CYTOCHALASIN D; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; MAP KINASE SIGNALING SYSTEM; MEMBRANE TRANSPORT PROTEINS; MICE; MYELIN PROTEINS; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEOLIPIDS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; THIAZOLIDINES;

EID: 68349136921     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2009.07.015     Document Type: Article

References (50)

1. Anastasi S., Baietti M.F., Frosi Y., Alemà S., and Segatto O. The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity. Oncogene 26 (2007) 7833-7846
2. Arsenian S., Weinhold B., Oelgeschläger M., Rüther U., and Nordheim A. Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 17 (1998) 6289-6299
3. Balza Jr. R.O., and Misra R.P. Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes. J. Biol. Chem. 281 (2006) 6498-6510
4. Buchwalter G., Gross C., and Wasylyk B. Ets ternary complex transcription factors. Gene 324 (2004) 1-14
5. Busche S., Descot A., Julien S., Genth H., and Posern G. Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling. J. Cell Sci. 121 (2008) 1025-1035
6. Chen J., Kitchen C.M., Streb J.W., and Miano J.M. Myocardin: a component of a molecular switch for smooth muscle differentiation. J. Mol. Cell. Cardiol. 34 (2002) 1345-1356
7. Cooper S.J., Trinklein N.D., Nguyen L., and Myers R.M. Serum response factor binding sites differ in three human cell types. Genome Res. 17 (2007) 136-144
8. Descot A., Rex-Haffner M., Courtois G., Bluteau D., Menssen A., Mercher T., Bernard O.A., Treisman R., and Posern G. OTT-MAL is a deregulated activator of serum response factor-dependent gene expression. Mol. Cell. Biol. 28 (2008) 6171-6181
9. Du K.L., Chen M., Li J., Lepore J.J., Mericko P., and Parmacek M.S. Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. J. Biol. Chem. 279 (2004) 17578-17586
10. Etkin A., Alarcon J.M., Weisberg S.P., Touzani K., Huang Y.Y., Nordheim A., and Kandel E.R. A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 50 (2006) 127-143
11. Ferby I., Reschke M., Kudlacek O., Knyazev P., Pantè G., Amann K., Sommergruber W., Kraut N., Ullrich A., Fässler R., and Klein R. Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat. Med. 12 (2006) 568-573
12. Fiorentino L., Pertica C., Fiorini M., Talora C., Crescenzi M., Castellani L., Alemà S., Benedetti P., and Segatto O. Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain. Mol. Cell. Biol. 20 (2000) 7735-7750
13. Gineitis D., and Treisman R. Differential usage of signal transduction pathways defines two types of serum response factor target gene. J. Biol. Chem. 276 (2001) 24531-24539
14. Hackel P.O., Gishizky M., and Ullrich A. Mig-6 is a negative regulator of the epidermal growth factor receptor signal. Biol. Chem. 382 (2001) 1649-1662
15. Knöll B., Kretz O., Fiedler C., Alberti S., Schütz G., Frotscher M., and Nordheim A. Serum response factor controls neuronal circuit assembly in the hippocampus. Nat. Neurosci. 9 (2006) 195-204
16. Koegel H., von Tobel L., Schäfer M., Alberti S., Kremmer E., Mauch C., Hohl D., Wang X.J., Beer H.D., Bloch W., et al. Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice. J. Clin. Invest. 119 (2009) 899-910
17. Kuwahara K., Barrientos T., Pipes G.C., Li S., and Olson E.N. Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol. Cell. Biol. 25 (2005) 3173-3181
18. Li J., Zhu X., Chen M., Cheng L., Zhou D., Lu M.M., Du K., Epstein J.A., and Parmacek M.S. Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proc. Natl. Acad. Sci. USA 102 (2005) 8916-8921
19. Li S., Chang S., Qi X., Richardson J.A., and Olson E.N. Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells. Mol. Cell. Biol. 26 (2006) 5797-5808
20. Lockman K., Hinson J.S., Medlin M.D., Morris D., Taylor J.M., and Mack C.P. Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. J. Biol. Chem. 279 (2004) 42422-42430
21. Mandl M., Slack D.N., and Keyse S.M. Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5. Mol. Cell. Biol. 25 (2005) 1830-1845
22. Medjkane S., Perez-Sanchez C., Gaggioli C., Sahai E., and Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat. Cell Biol. 11 (2009) 257-268
23. Milyavsky M., Shats I., Cholostoy A., Brosh R., Buganim Y., Weisz L., Kogan I., Cohen M., Shatz M., Madar S., et al. Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect. Cancer Cell 11 (2007) 133-146
24. Miralles F., Posern G., Zaromytidou A.I., and Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113 (2003) 329-342
25. Muehlich S., Cicha I., Garlichs C.D., Krueger B., Posern G., and Goppelt-Struebe M. Actin-dependent regulation of connective tissue growth factor. Am. J. Physiol. Cell Physiol. 292 (2007) C1732-C1738
26. Muehlich S., Wang R., Lee S.M., Lewis T.C., Dai C., and Prywes R. Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization. Mol. Cell. Biol. 28 (2008) 6302-6313
27. Murai K., and Treisman R. Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-actin signaling to SRF and potentiates transcriptional activation by Elk-1. Mol. Cell. Biol. 22 (2002) 7083-7092
28. Oh J., Richardson J.A., and Olson E.N. Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation. Proc. Natl. Acad. Sci. USA 102 (2005) 15122-15127
29. Philippar U., Schratt G., Dieterich C., Muller J.M., Galgoczy P., Engel F.B., Keating M.T., Gertler F., Schule R., Vingron M., and Nordheim A. The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Mol. Cell 16 (2004) 867-880
30. Pipes G.C., Creemers E.E., and Olson E.N. The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev. 20 (2006) 1545-1556
31. Posern G., and Treisman R. Actin' together: serum response factor, its cofactors and the link to signal transduction. Trends Cell Biol. 16 (2006) 588-596
32. Posern G., Sotiropoulos A., and Treisman R. Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor. Mol. Biol. Cell 13 (2002) 4167-4178
33. Posern G., Miralles F., Guettler S., and Treisman R. Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL. EMBO J. 23 (2004) 3973-3983
34. Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C., and Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402 (1999) 884-888
35. Sasazuki T., Sawada T., Sakon S., Kitamura T., Kishi T., Okazaki T., Katano M., Tanaka M., Watanabe M., Yagita H., et al. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J. Biol. Chem. 277 (2002) 28853-28860
36. Schratt G., Philippar U., Berger J., Schwarz H., Heidenreich O., and Nordheim A. Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J. Cell Biol. 156 (2002) 737-750
37. Schratt G., Philippar U., Hockemeyer D., Schwarz H., Alberti S., and Nordheim A. SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. EMBO J. 23 (2004) 1834-1844
38. Selvaraj A., and Prywes R. Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent. BMC Mol. Biol. 5 (2004) 13
39. Sotiropoulos A., Gineitis D., Copeland J., and Treisman R. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell 98 (1999) 159-169
40. Sun Q., Chen G., Streb J.W., Long X., Yang Y., Stoeckert Jr. C.J., and Miano J.M. Defining the mammalian CArGome. Genome Res. 16 (2006) 197-207
41. Sun Y., Boyd K., Xu W., Ma J., Jackson C.W., Fu A., Shillingford J.M., Robinson G.W., Hennighausen L., Hitzler J.K., et al. Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol. Cell. Biol. 26 (2006) 5809-5826
42. Tang R.H., Zheng X.L., Callis T.E., Stansfield W.E., He J., Baldwin A.S., Wang D.Z., and Selzman C.H. Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression. Proc. Natl. Acad. Sci. USA 105 (2008) 3362-3367
43. Treisman R. Journey to the surface of the cell: Fos regulation and the SRE. EMBO J. 14 (1995) 4905-4913
44. Vartiainen M.K., Guettler S., Larijani B., and Treisman R. Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL. Science 316 (2007) 1749-1752
45. Wang Z., Wang D.Z., Hockemeyer D., McAnally J., Nordheim A., and Olson E.N. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428 (2004) 185-189
46. Xu D., Patten R.D., Force T., and Kyriakis J.M. Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling. Mol. Cell. Biol. 26 (2006) 5043-5054
47. Zaromytidou A.I., Miralles F., and Treisman R. MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain. Mol. Cell. Biol. 26 (2006) 4134-4148
48. Zhang X., Pickin K.A., Bose R., Jura N., Cole P.A., and Kuriyan J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature 450 (2007) 741-744
49. Zhang Y.W., Staal B., Su Y., Swiatek P., Zhao P., Cao B., Resau J., Sigler R., Bronson R., and Vande Woude G.F. Evidence that MIG-6 is a tumor-suppressor gene. Oncogene 26 (2007) 269-276
50. Zhou J., Hu G., and Herring B.P. Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1. Mol. Cell. Biol. 25 (2005) 9874-9885