MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain

Molecular and Cellular Biology

Volumn 26, Issue 11, 2006, Pages 4134-4148

  Zaromytidou, Alexia Ileana ^a   Miralles, Francesc ^a   Treisman, Richard ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTATHIONE TRANSFERASE; MADS DOMAIN PROTEIN; MAL PROTEIN; MYOCARDIN; MYOCARDIN RELATED TRANSCRIPTION FACTOR; PROTEIN; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; REPORTER GENE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEUS; DNA; DNA-BINDING PROTEINS; HYDROPHOBICITY; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NIH 3T3 CELLS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SERUM RESPONSE FACTOR; TERNARY COMPLEX FACTORS; TRANS-ACTIVATORS;

EID: 33646864348     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01902-05     Document Type: Article

References (41)

1. Acton, T. B., J. Mead, A. M. Steiner, and A. K. Vershon. 2000. Scanning mutagenesis of Mcm1: residues required for DNA binding, DNA bending, and transcriptional activation by a MADS-box protein. Mol. Cell. Biol. 20:1-11.
2. Acton, T. B., H. Zhong, and A. K. Vershon. 1997. DNA-binding specificity of Mcm1: operator mutations that alter DNA-bending and transcriptional activities by a MADS box protein. Mol. Cell. Biol. 17:1881-1889.
3. Bruhn, L., and G. F. Sprague, Jr. 1994. MCM1 point mutants deficient in expression of α-specific genes: residues important for interaction with α1. Mol. Cell. Biol. 14:2534-2544.
4. Carr, E. A., J. Mead, and A. K. Vershon. 2004. Alpha1-induced DNA bending is required for transcriptional activation by the Mcm1-alpha1 complex. Nucleic Acids Res. 32:2298-2305.
5. Cen, B., A. Selvaraj, R. C. Burgess, J. K. Hitzler, Z. Ma, S. W. Morris, and R. Prywes. 2003. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol. Cell. Biol. 23:6597-6608.
6. Dalton, S., and R. Treisman. 1992. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell 68:597-612.
7. Gineitis, D., and R. Treisman. 2001. Differential usage of signal transduction pathways defines two types of serum response factor target gene. J. Biol. Chem. 276:24531-24539.
8. Hassler, M., and T. J. Richmond. 2001. The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex. EMBO J. 20:3018-3028.
9. Hill, C. S., R. Marais, S. John, J. Wynne, S. Dalton, and R. Treisman. 1993. Functional analysis of a growth factor-responsive transcription factor complex. Cell 73:395-406.
10. Hill, C. S., J. Wynne, and R. Treisman. 1994. Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain. EMBO J. 13:5421-5432.
11. Howell, M., and C. S. Hill. 1997. XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos. EMBO J. 16:7411-7421.
12. Iyer, D., N. Belaguli, M. Fluck, B. G. Rowan, L. Wei, N. L. Weigel, F. W. Booth, H. F. Epstein, R. J. Schwartz, and A. Balasubramanyam. 2003. Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription. Biochemistry 42:7477-7486.
13. Klejman, M. P., L. A. Pereira, H. J. van Zeeburg, S. Gilfillan, M. Meisterernst, and H. T. Timmers. 2004. NC2α interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein. Mol. Cell. Biol. 24:10072-10082.
14. Lim, F. L., A. Hayes, A. G. West, A. Pic-Taylor, Z. Darieva, B. A. Morgan, S. G. Oliver, and A. D. Sharrocks. 2003. Mcm1p-induced DNA bending regulates the formation of ternary transcription factor complexes. Mol. Cell. Biol. 23:450-461.
15. Ling, Y., J. H. Lakey, C. E. Roberts, and A. D. Sharrocks. 1997. Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain transcription factor Elk-1. EMBO J. 16:2431-2440.
16. Ling, Y., A. G. West, E. C. Roberts, J. H. Lakey, and A. D. Sharrocks. 1998. Interaction of transcription factors with serum response factor. Identification of the Elk-1 binding surface. J. Biol. Chem. 273:10506-10514.
17. Ma, Z., S. W. Morris, V. Valentine, M. Li, J. A. Herbrick, X. Cui, D. Bouman, Y. Li, P. K. Mehta, D. Nizetic, Y. Kaneko, G. C. Chan, L. C. Chan, J. Squire, S. W. Scherer, and J. K. Hitzler. 2001. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13)of acute megakaryoblastic leukemia. Nat. Genet. 28:220-221.
18. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381-393.
19. Mead, J., A. R. Bruning, M. K. Gill, A. M. Steiner, T. B. Acton, and A. K. Vershon. 2002. Interactions of the Mcm1 MADS box protein with cofactors that regulate mating in yeast. Mol. Cell. Biol. 22:4607-4621.
20. Mead, J., H. Zhong, T. B. Acton, and A. K. Vershon. 1996. The yeast α2 and Mcm1 proteins interact through a region similar to a motif found in homeodomain proteins of higher eukaryotes. Mol. Cell. Biol. 16:2135-2143.
21. Mercher, T., M. B. Coniat, R. Monni, M. Mauchauffe, F. N. Khac, L. Gressin, F. Mugneret, T. Leblanc, N. Dastugue, R. Berger, and O. A. Bernard. 2001. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc. Natl. Acad. Sci. USA. 98:5776-5779.
22. Messenguy, F., and E. Dubois. 2003. Role of MADS box proteins and their cofactors in combinatorial control of gene expression and cell development. Gene 316:1-21.
23. Miralles, F., G. Posern, A. I. Zaromytidou, and R. Treisman. 2003. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113:329-342.
24. Murai, K., and R. Treisman. 2002. Interaction of serum response factor (SRF) with the Elk-1 B-box inhibits RhoA-actin signalling to SRF and potentiates transcriptional activation by Elk-1. Mol. Cell. Biol. 22:7083-7092.
25. Nurrish, S. J., and R. Treisman. 1995. DNA binding specificity determinants in MADS-box transcription factors. Mol. Cell. Biol. 15:4076-4085.
26. Pellegrini, L., S. Tan, and T. J. Richmond. 1995. Structure of serum response factor core bound to DNA. Nature 376:490-498.
27. Sasazuki, T., T. Sawada, S. Sakon, T. Kitamura, T. Kishi, T. Okazaki, M. Katano, M. Tanaka, M. Watanabe, H. Yagita, K. Okumura, and H. Nakano. 2002. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J. Biol. Chem. 277:28853-28860.
28. Selvaraj, A., and R. Prywes. 2003. Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. J. Biol. Chem. 278:41977-41987.
29. Sharrocks, A. D., and P. Shore. 1995. DNA bending in the ternary nucleoprotein complex at the c-fos promoter. Nucleic Acids Res. 23: 2442-2449.
30. Shore, P., and A. D. Sharrocks. 1994. The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1. Mol. Cell. Biol. 14:3283-3291.
31. Shore, P., and A. D. Sharrocks. 1995. The MADS-box family of transcription factors. Eur. J. Biochem. 229:1-13.
32. Tan, S., and T. J. Richmond. 1998. Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex. Nature 391:660-666.
33. Treisman, R. 1986. Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell 46:567-574.
34. Treisman, R. 1994. Ternary complex factors: growth factor regulated transcriptional activators. Curr. Opin. Genet. Dev. 4:96-101.
35. Vershon, A. K., and A. D. Johnson. 1993. A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha 2 protein and the MCM1 protein. Cell 72:105-112.
36. Wang, D., P. S. Chang, Z. Wang, L. Sutherland, J. A. Richardson, E. Small, P. A. Krieg, and E. N. Olson. 2001. Activation of cardiac gene expression by myocardin, a transcriptionai cofactor for serum response factor. Cell 105: 851-862.
37. Wang, D. Z., S. Li, D. Hockemeyer, L. Sutherland, Z. Wang, G. Schratt, J. A. Richardson, A. Nordheim, and E. N. Olson. 2002. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc. Natl. Acad. Sci. USA 99:14855-14860.
38. Wang, Y., and R. Prywes. 2000. Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites. Oncogene 19:1379-1385.
39. Wang, Z., D. Z. Wang, D. Hockemeyer, J. McAnally, A. Nordheim, and E. N. Olson. 2004. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428:185-189.
40. West, A. G., and A. D. Sharrocks. 1999. MADS-box transcription factors adopt alternative mechanisms for bending DNA. J. Mol. Biol. 286:1311-1323.
41. West, A. G., P. Shore, and A. D. Sharrocks. 1997. DNA binding by MADS-box transcription factors: a molecular mechanism for differential DNA bending. Mol. Cell. Biol. 17:2876-2887.