TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients

Clinical Immunology

Volumn 129, Issue 1, 2008, Pages 40-48

  Wu, Pingping ^a,b   Wu, Jiang ^c   Liu, Shuxun ^a   Han, Xinghai ^a   Lu, Jianqiang ^a   Shi, Yeqing ^a   Wang, Jianli ^b   Lu, Liwei ^d   Cao, Xuetao ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

BDCA2; Plasmacytoid dendritic cells; Systemic lupus erythematosus; TLR7; TLR9

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; BLOOD DENDRITIC CELL ANTIGEN 2; CD40 ANTIGEN; CD86 ANTIGEN; CELL ANTIGEN; CHEMOKINE RECEPTOR CCR7; CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE ACTIVITY; DOWN REGULATION; HUMAN; HUMAN CELL; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

ANTIGEN-ANTIBODY COMPLEX; CYTOKINES; DENDRITIC CELLS; DOWN-REGULATION; HUMANS; LECTINS, C-TYPE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEMBRANE GLYCOPROTEINS; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, IMMUNOLOGIC; TH1 CELLS; TH2 CELLS; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9; UP-REGULATION;

EID: 51249104878     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2008.06.004     Document Type: Article

References (35)

1. Krieg A.M., and Vollmer J. Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity. Immunol. Rev 220 (2007) 251-269
2. Tian J., Avalos A.M., Mao S.Y., Chen B., Senthil K., Wu H., Parroche P., Drabic S., Golenbock D., Sirois C., Hua J., An L.L., Audoly L., La Rosa G., Bierhaus A., Naworth P., Marshak-Rothstein A., Crow M.K., Fitzgerald K.A., Latz E., Kiener P.A., and Coyle A.J. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol 8 (2007) 487-496
3. Blanco P., Palucka A.K., Gill M., Pascual V., and Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 294 (2001) 1540-1543
4. Gilliet M., Conrad C., Geiges M., Cozzio A., Thürlimann W., Burg G., Nestle F.O., and Dummer R. Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch Dermatol 140 (2004) 1490-1495
5. Viglianti G.A., Lau C.M., Hanley T.M., Miko B.A., Shlomchik M.J., and Marshak-Rothstein A. Activation of autoreactive B cells by CpG dsDNA. Immunity 19 (2003) 837-847
6. Liu Y.J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol 23 (2005) 275-306
7. Theofilopoulos A.N., Baccala R., Beutler B., and Kono D.H. Type I interferons (a/β) in immunity and autoimmunity. Annu. Rev. Immunol 23 (2005) 307-335
8. Hanabuchi S., Watanabe N., Wang Y.H., Wang Y.H., Ito T., Shaw J., Cao W., Qin F.X., and Liu Y.J. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood 107 (2006) 3617-3623
9. de Waal Malefyt R. The role of type I interferons in the differentiation and function of Th1 and Th2 cells. Semin. Oncol 24 (1997) S9-94-S9-98
10. Jego G., Palucka A.K., Blanck J.P., Chalouni C., Pascual V., and Banchereau J. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19 (2003) 225-234
11. Su L., and David M. Inhibition of B cell receptor-mediated apoptosis by IFN. J. Immunol 162 (1999) 6317-6321
12. Fiore N., Castellano G., Blasi A., Capobianco C., Loverre A., Montinaro V., Netti S., Torres D., Manno C., Grandaliano G., Ranieri E., Schena F.P., and Gesualdo L. Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritis. Mol. Immunol 45 (2008) 259-265
13. Gottenberg J.E., Cagnard N., Lucchesi C., Letourneur F., Mistou S., Lazure T., Jacques S., Ba N., Ittah M., Lepajolec C., Labetoulle M., Ardizzone M., Sibilia J., Fournier C., Chiocchia G., and Mariette X. Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome. Proc. Natl. Acad. Sci. U S A 103 (2006) 2770-2775
14. Nestle F.O., Conrad C., Tun-Kyi A., Homey B., Gombert M., Boyman O., Burg G., Liu Y.J., and Gilliet M. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J. Exp. Med 202 (2005) 135-143
15. Prinz M., Garbe F., Schmidt H., Mildner A., Gutcher I., Wolter K., Piesche M., Schroers R., Weiss E., Kirschning C.J., Rochford C.D., Brück W., and Becher B. Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. J. Clin. Invest 116 (2006) 456-464
16. Dzionek A., Fuchs A., Schmidt P., Cremer S., Zysk M., Miltenyi S., Buck D.W., and Schmitz J. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J.Immunol 165 (2000) 6037-6046
17. Dzionek A., Sohma Y., Nagafune J., Cella M., Colonna M., Facchetti F., Gunther G., Johnston I., Lanzavecchia A., Nagasaka T., Okada T., Vermi W., Winkels G., Yamamoto T., Zysk M., Yamaguchi Y., and Schmitz J. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J.Exp.Med 194 (2001) 1823-1834
18. Röck J., Schneider E., Grün J.R., Grützkau A., Küppers R., Schmitz J., and Winkels G. CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCgamma2. Eur. J. Immunol 37 (2007) 3564-3575
19. Fanning S.L., George T.C., Feng D., Feldman S.B., Megjugorac N.J., Izaguirre A.G., and Fitzgerald-Bocarsly P. Receptor cross-linking on human plasmacytoid dendritic cells leads to the regulation of IFN-alpha production. J. Immunol 177 (2006) 5829-5839
20. Verthelyi D., Ishii K.J., Gursel M., Takeshita F., and Klinman D.M. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J.Immunol 166 (2001) 2372-2377
21. Kadowaki N., Ho S., Antonenko S., de Waal Malefyt R., Kastelein R.A., Bazan F., and Liu Y.J. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med 194 (2001) 863-869
22. Sallusto F., and Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J.Exp.Med 179 (1994) 1109-1118
23. Liu S., Yu Y., Zhang M., Wang W., and Cao X. The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells. J. Immunol 166 (2001) 5407-5415
24. Wan T., Zhou X., Chen G., An H., Chen T., Zhang W., Liu S., Jiang Y., Yang F., Wu Y., and Cao X. Novel heat shock protein Hsp70 L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. Blood 103 (2004) 1747-1754
25. Mariani M., Lang R., Binda E., Panina-Bordignon P., and D'Ambrosio D. Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells. Eur. J. Immunol 34 (2004) 231-240
26. Loetscher P., Uguccioni M., Bordoli L., Baggiolini M., Moser B., Chizzolini C., and Dayer J.M. CCR5 is characteristic of Th1 lymphocytes. Nature 391 (1998) 344-345
27. Preble O.T., Black R.J., Friedman R.M., Klippel J.H., and Vilcek J. Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon. Science 216 (1982) 429-431
28. Ronnblom L., and Alm G.V. A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J.Exp.Med 194 (2001) F59-F63
29. van Liempt E., van Vliet S.J., Engering A., García Vallejo J.J., Bank C.M., Sanchez-Hernandez M., van Kooyk Y., and van Die I. Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation. Mol. Immunol 44 (2007) 2605-2615
30. Fujii S., Liu K., Smith C., Bonito A.J., and Steinman R.M. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J.Exp.Med 199 (2004) 1607-1618
31. Viola A., and Lanzavecchia A. T cell activation determined by T cell receptor number and tunable thresholds. Science 273 (1996) 104-106
32. Sato K., Yamashita N., Yamashita N., Baba M., and Matsuyama T. Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity 18 (2003) 367-379
33. Tamada K., Tamura H., Flies D., Fu Y.X., Celis E., Pease L.R., Blazar B.R., and Chen L. Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. J. Clin. Invest 109 (2002) 549-557
34. Chakrabarti D., Hultgren B., and Stewart T.A. IFN-alpha induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7.2. J. Immunol 157 (1996) 522-528
35. Banchereau J., and Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25 (2006) 383-392