α-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 5933-5949

  Orrling, Kristina M ^a   Marzahn, Melissa R ^b   Gutiérrez de Terán, Hugo ^c   Åqvist, Johan ^d   Dunn, Ben M ^b   Larhed, Mats ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c Pediatric Nutrition Research Group Health Research Institute of Santiago de Compostela   (Spain)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Inhibitors; Linear interaction energy mehtod; Malaria; Microwave assisted synthesis; Molecular dynamics; Plasmepsin

Indexed keywords

ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; CATHEPSIN D; NORSTATINE DERIVATIVE; PLASMEPSIN II; PLASMEPSIN INHIBITOR; PLASMEPSIN IV; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM OVALE;

AMINOCAPROIC ACIDS; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; COMPUTER SIMULATION; HUMANS; PLASMODIUM; PROTEASE INHIBITORS; PROTOZOAN PROTEINS; STEREOISOMERISM; THERMODYNAMICS;

PLASMODIUM FALCIPARUM; PLASMODIUM OVALE;

EID: 68149091436     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.065     Document Type: Article

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