Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries

Biochemistry

Volumn 44, Issue 6, 2005, Pages 1768-1779

  Beyer, Bret B ^a   Johnson, Jodie V ^b   Chung, Alfred Y ^c   Li, Tang ^c   Madabushi, Amrita ^a   Agbandje McKenna, Mavis ^a   McKenna, Robert ^a   Dame, John B ^c   Dunn, Ben M ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYMES; HYDROPHOBICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEINS;

ASPARTIC PEPTIDASES; CLEAVAGE PRODUCTS; DIGESTIVE ENZYMES; SUBSTRATE INTERACTIONS;

AMINO ACIDS;

ASPARTIC PEPTIDASE; CHROMOGENIC SUBSTRATE; OCTAPEPTIDE; PEPTIDASE; PEPTIDE LIBRARY; PLASMEPSIN I; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CALCULATION; CATALYSIS; DIGESTION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROPHOBICITY; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PLASMODIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CHROMOGENIC COMPOUNDS; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HYDROLYSIS; MALARIA; MODELS, MOLECULAR; PEPTIDE LIBRARY; PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM VIVAX; PROTEASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 13644263256     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047886u     Document Type: Article

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