Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins

Cancer Research

Volumn 63, Issue 8, 2003, Pages 1798-1805

  Brady, Nicola ^a   Gaymes, Terry J ^a   Cheung, Manyee ^a   Mufti, Ghulam J ^a   Rassool, Feyruz V ^a,b  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NONHOMOLOGOUS END JOINING PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DRUG INDUCED DISEASE; GENOME; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; INTERMETHOD COMPARISON; MISMATCH REPAIR; MYELOID LEUKEMIA; PRIORITY JOURNAL;

ANTIBODIES; ANTIGENS, NUCLEAR; APHIDICOLIN; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA, NEOPLASM; DNA-BINDING PROTEINS; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA, MYELOID;

EID: 0037447303     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Olive, P. L. The role of single and double strand breaks in cell killing by ionizing radiation. Radiat. Res., 150: S42-S51, 2000.
2. Morgan, W. F., Corcoran, J., Hartmann, A., Kaplan, M. I., Limoli, C. L., and Ponnaiya, B. Double strand breaks, chromosomal rearrangements, and genomic instability. Mutat. Res., 404: 125-128, 1998.
3. Jeggo, P. A. DNA double strand breakage and repair. Adv. Genet., 38: 185-218, 1998.
4. Elliott, B. and Jasin, M. Double-strand breaks and translocations in cancer. Cell. Mol. Lif. Sci., 59: 373-385, 2002.
5. Khanna, K. K., and Jackson, S. P. DNA double strand breaks: signalling, repair and the cancer connection. Nat. Genet., 27: 247-254, 2001.
6. Zdzienicka, M. Z. Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. Mutat. Res., 336: 203-213, 1995.
7. Mimori, T., and Hardin, J. A. Mechanism of action between ku protein and DNA. J. Biol. Chem., 261: 10375-10379, 1986.
8. Falzon, M., Fewell, J. W., and Kuff, E. L. EBP-80, a transcription factor closely resembling the human autoantigen ku, recognizes single- to double-strand transitions in DNA. J. Biol. Chem., 268: 10546-10552, 1993.
9. Gottlieb, T., and Jackson, S. The DNA-dependent protein kinase: requirement for DNA ends and association with ku antigen. Cell, 72: 131-142, 1993.
10. Grawunder, U., Wilm, M., Wu, X. T., Kulesza, P., Wilson, T. E., Mann, M., and Lieber, M. R. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature (Lond.), 388: 492-495, 1997.
11. Roth, D. B., Porter, T. N., and Wilson, J. H. Mechanism of nonhomologous recombination in mammalian cells. Mol. Cell. Biol., 5: 2599-2607, 1985.
12. Roth, D. B., and Wilson, J. H. Nonhomologous recombination in mammalian cells: role for the short sequence homologies in the joining reaction. Mol. Cell. Biol., 6: 4295-4304, 1986.
13. Pierce, A. J., and Jasin, M. NHEJ deficiency and disease. Mol. Cell., 6: 1160-1161, 2001.
14. Difilipiantonio, M. J., Zhu, J., Chen, H. T., Meffre, E., Nussenzweig, M. C., Max, E. E., Ried, T., and Nussenzweig, A. DNA repair protein ku80 suppresses chromosomal aberrations and malignant transformation. Nature (Lond.), 400: 510-513, 2000.
15. Rothkamm, K., Kuhne, M., Jeggo, P. A., and Lobrich, M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res., 61: 3886-3893, 2001.
16. Rief, N., and Lobrich, M. Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells. J. Biol. Chem., 277: 20572-20582, 2002.
17. Elliott, B., and Jasin, M. Double-strand breaks and translocations in cancer. Cell. Mol. Lif. Sci., 59: 373-385, 2002.
18. Gaymes, T. J., North, P. S., Brady, N., Hickson, I. D., Mufti, G. J., and Rassool, F. V. Increased error-prone nonhomologous DNA end-joining: a proposed mechanism of chromosomal instability in Bloom's syndrome. Oncogene, 21: 2525-2533, 2002.
19. Gaymes, T. J., Mufti, G. J., and Rassool, F. V. Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependant on the Ku70/86 heterodimer. Cancer Res., 62: 2791-2797, 2002.
20. Yunis, J. J., Lee Soreng, L., and Bowe, A. E. Fragile sites are targets of diverse mutagens and carcinogens. Oncogene, 1: 59-69, 1987.
21. Baumann, P., and West, S. C. DNA end-joining catalyzed by human cell-free extracts. Proc. Natl. Acad. Sci. USA, 95: 14066-14070, 1998.
22. Raderschall, E., Golub, E. I., and Haaf, T. Nuclear foci of mammalian recombination proteins are located at DNA regions after DNA damage. Proc. Natl. Acad. Sci. USA, 96: 1921-1926, 1999.
23. Nagai, M., Seki, S., Kitahara, T., Abe, T., Minato, K., Watanabe, S., and Shimoyama, M. A novel human myelomonocytoid cell line, P39/Tsugane, derived from overt leukemia following myelodysplastic syndrome. Gann, 75: 1100-1107, 1984.
24. Koeffler, H. P., and Golde, D. W. Human myeloid leukemia cell lines. Blood, 56: 344-350, 1980.
25. Friedberg, E., Walker, G. and Siede W. (eds.) DNA repair and mutagenesis. Washington DC: ASM Press, 1995.
26. Preston, D. L., Kusumi, S., Tomanaga, M., Izumi, S., Ron, E., Kuramoto, A., Kamada, N., Dohy, H., Mtasui, T., Nonaka, H., Thompson, D. E., Soda, M., and Mabuchi, K. Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma, multiple myeloma, 1950-1987. Radiat. Res., 137: S68-S97, 1994.
27. Nakanishi, M., Tanaka, K., Shintani, T., Takahashi, T., and Kamada, N. Chromosomal instability in acute myelocytic leukemia and myelodysplastic syndrome patients among atomic bomb survivors. J. Rad. Res., 40: 159-167, 1999.
28. Philip, P., and Pedersen-Bjergaard, J. Cytogenetic, clinical, and cytologic characteristics of radiotherapy-related leukemias. Cancer Genet. Cytogenet., 31: 227-236, 1988.