Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 24, Issue 2, 2009, Pages 499-505

  Morsy, Salwa M I ^a   Badawi, Abdelfattah M ^a   Cecchi, Alessandro ^b   Scozzafava, Andrea ^b   Supuran, Claudiu T ^b  

^a Egyptian Petroleum Research Institute   (Egypt)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

CA IX; Cancer cell lines; Carbonic anhydrase; Cytotoxic; H460; HCT 116; Inhibitors; MCF 7

Indexed keywords

BIPHENYLSULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE; ISOENZYME; SULFONAMIDE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; BREAST TUMOR; CELL STRAIN HCT116; CHEMISTRY; COLON TUMOR; DOSE RESPONSE; DRUG ANTAGONISM; ENZYMOLOGY; FEMALE; LUNG TUMOR; METABOLISM;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HCT116 CELLS; HUMANS; ISOENZYMES; LUNG NEOPLASMS; SULFONAMIDES;

EID: 68049113519     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802218441     Document Type: Article

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