Cell proliferation and replacement following contusive spinal cord injury

GLIA

Volumn 50, Issue 3, 2005, Pages 247-257

  Zai, Laila J ^a   Wrathall, Jean R ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NRB EG20 ^*  (United States)

Author keywords

Astrocyte; BrdU; Differentiation; Glia; NG2; Oligodendrocyte; Precursors; Progenitors

Indexed keywords

BIOLOGICAL MARKER; BROXURIDINE; CELL ANTIGEN; CELL MARKER; GLIAL FIBRILLARY ACIDIC PROTEIN; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; PROTEOCHONDROITIN SULFATE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ASSAY; CELL DENSITY; CELL DIVISION; CELL LABELING; CELL LOSS; CELL MATURATION; CELL PROLIFERATION; CELL RENEWAL; CELL STIMULATION; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; GLIA CELL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MICROGLIA; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; SPINAL CORD INJURY; WHITE MATTER;

ANIMALS; ANTIGENS, SURFACE; ASTROCYTES; BIOLOGICAL MARKERS; BROMODEOXYURIDINE; CELL DIFFERENTIATION; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE FIBERS, MYELINATED; NERVE REGENERATION; NEUROGLIA; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; STEM CELLS; THORACIC VERTEBRAE;

EID: 20044362061     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.20176     Document Type: Article

References (34)

1. Barres BA, Raff MC. 1993. Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons. Nature 361:258-260.
2. Barres BA, Raff MC. 1999. Axonal control of oligodendrocyte development. J Cell Biol 147:1123-1128.
3. Basso DM, Beattie MS, Bresnahan JC. 1995. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21.
4. Beattie MS, Bresnahan JC, Komon J, Tovar CA, Van Meter M, Anderson DK, Faden AI, Hsu CY, Noble LJ, Salzman S, Young W. 1997. Endogenous repair after spinal cord contusion injuries in the rat. Exp Neurol 148:453-463.
5. Beattie MS, Hermann GE, Rogers RC, Bresnahan JC. 2002. Cell death in models of spinal cord injury. Prog Brain Res 137:37-47.
6. Belachew S, Chittajallu R, Aguirre AA, Yuan X, Kirby M, Anderson S, Gallo V. 2003. Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons. J Cell Biol 161:169-186.
7. Blakemore WF, Patterson RC. 1978. Suppression of remyelination in the CNS by X-irradiation. Acta Neuropathol (Berl) 42:105-13.
8. Blight AR. 1983. Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling. Neuroscience 10:521-543.
9. Bu J, Akhtar N, Nishiyama A. 2001. Transient expression of the NG2 proteoglycan by a subpopulation of activated macrophages in an excitotoxic hippocampal lesion. Glia 34:296-310.
10. Canoll PD, Kraemer R, Teng KK, Marchionni MA, Salzer JL. 1999. GGF/neuregulin induces a phenotypic reversion of oligodendrocytes. Mol Cell Neurosci 13:79-94.
11. Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Seattle MS. 1997. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 3:73-76.
12. Dawson MR, Levine JM, Reynolds R. 2000. NG2-expressing cells in the central nervous system: are they oligodendroglial progenitors? J Neurosci Res 61:471-479.
13. Fernandez PA, Tang DG, Cheng L, Prochiantz A, Mudge AW, Raff MC. 2000. Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Neuron 28:81-90.
14. Gale K, Kerasidis H, Wrathall JR. 1985. Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment. Exp Neurol 88:123-134.
15. Grossman SD, Rosenberg LJ, Wrathall JR. 2001. Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion. Exp Neurol 168:273-282.
16. Horner PJ, Power AE, Kempermann G, Kuhn HG, Palmer TD, Winkler J, Thal LJ, Gage FH. 2000. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J Neurosci 20:2218-2228.
17. Ishii K, Toda M, Nakai Y, Asou H, Watanabe M, Nakamura M, Yato Y, Fujimura Y, Kawakami Y, Toyama Y, Uyemura K. 2001. Increase of oligodendrocyte progenitor cells after spinal cord injury. J Neurosci Res 65:500-507.
18. Jones LL, Yamaguchi Y, Stallcup WB, Tuszynski MH. 2002. NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci 22:2792-2803.
19. Kondo T, Raff M. 2000. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289:1754-1757.
20. Levine JM, Reynolds R, Fawcett JW. 2001. The oligodendrocyte precursor cell in health and disease. Trends Neurosci 24:39-47.
21. Levison SW, Young GM, Goldman JE. 1999. Cycling cells in the adult rat neocortex preferentially generate oligodendroglia. J Neurosci Res 57:435-446.
22. McTigue DM, Wei P, Stokes BT. 2001. Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. J Neurosci 21:3392-3400.
23. Mocchetti I, Wrathall JR. 1995. Neurotrophic factors in central nervous system trauma. J Neurotrauma 12:853-870.
24. Murakami Y, Furukawa S, Nitta A, Furukawa Y. 2002. Accumulation of nerve growth factor protein at both rostral and caudal stumps in the transected rat spinal cord. J Neurol Sci 198:63-69.
25. Neuberger TJ, De Vries GH. 1993. Distribution of fibroblast growth factor in cultured dorsal root ganglion neurons and Schwann cells. II. Redistribution after neural injury. J Neurocytol 22:449-460.
26. Nishiyama A, Lin XH, Giese N, Heldin CH, Stallcup WB. 1996. Colocalization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain. J Neurosci Res 43:299-314.
27. Ohta K, Inokuchi T, Gen E, Chang J. 2001. Ultrastructural study of anterograde transport of glial cell line-derived neurotrophic factor from dorsal root ganglion neurons of rats towards the nerve terminal. Cells Tissues Organs 169:410-421.
28. Rosenberg LJ, Zai LJ, Wrathall JR. 2005. Chronic alterations in the cellular composition of spinal cord white matter following contusion injury. Glia 49:107-120.
29. Shihabuddin LS, Horner PJ, Ray J, Gage FH. 2000. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci 20:8727-8735.
30. Stegmuller J, Schneider S, Hellwig A, Garwood J, Trotter J. 2002. AN2, the mouse homologue of NG2, is a surface antigen on glial precursor cells implicated in control of cell migration. J Neurocytol 31:497-505.
31. Tator CH, Fehlings MG. 1991. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75:15-26.
32. Tzeng SF, Bresnahan JC, Beattie MS, de Vellis J. 2001. Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injury. J Neurosci Res 66:1161-1172.
33. Wrathall JR, Pettegrew RK, Harvey F. 1985. Spinal cord contusion in the rat: production of graded, reproducible, injury groups. Exp Neurol 88:108-122.
34. Wrathall JR, Li W, Hudson LD. 1998. Myelin gene expression after experimental contusive spinal cord injury. J Neurosci 18:8780-8793.