TNF-α blockage in a mouse model of SCI: Evidence for improved outcome

Shock

Volumn 29, Issue 1, 2008, Pages 32-41

  Genovese, Tiziana ^a,b   Mazzon, Emanuela ^a,b   Crisafulli, Concetta ^a   Di Paola, Rosanna ^a,b   Muià, Carmelo ^a,b   Esposito, Emanuela ^b,c   Bramanti, Placido ^b   Cuzzocrea, Salvatore ^a,b  

^a UNIVERSITY OF MESSINA   (Italy)

^b IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Apoptosis; Cytokine expression; Neutrophil infiltration; Trauma

Indexed keywords

FAS LIGAND; INFLIXIMAB; MYELOPEROXIDASE; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CLIP; CONTROLLED STUDY; ENZYME ACTIVITY; GENE THERAPY; LAMINECTOMY; MOUSE; MYELITIS; NEUTROPHIL CHEMOTAXIS; NICK END LABELING; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; SCORING SYSTEM; SPINAL CORD INJURY;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; DISEASE MODELS, ANIMAL; FAS LIGAND PROTEIN; INTERLEUKIN-1BETA; MICE; MICE, KNOCKOUT; MODELS, NEUROLOGICAL; NEUTROPHILS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SPINAL CORD; SPINAL CORD INJURIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 37549029154     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/shk.0b013e318059053a     Document Type: Article

References (37)

1. Bartholdi D, Schwab ME: Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat. Brain Res 672:177-186, 1995.
2. Harrington JF, Messier AA, Levine A, Szmydynger-Chodobska J, Chodobski A: Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury. J Neurotrauma 22:919-928, 2005.
3. Hsu H, Shu HB, Pan MG, Goeddel DV: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84:299-308, 1996.
4. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U, Brenner D, Manns M, Trautwein C: Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology 119:446-460, 2000.
5. Grell M, Wajant H, Zimmermann G, Scheurich P: The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc Natl Acad Sci U S A 95:570-575, 1998.
6. Tartaglia LA, Weber RF, Figari IS, Reynolds C, Palladino MA Jr, Goeddel DV: The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc Natl Acad Sci U S A 88:9292-9296, 1991.
7. Liu ZG, Hsu H, Goeddel DV, Karin M: Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87:565-576, 1996.
8. Kapadia S, Torre-amione G, Yokoyama T, Mann DL: Soluble tumor necrosis factor binding proteins modulate the negative inotropic effects of TNF-α in vitro. Am J Physiol 37:517-525, 1995.
9. Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muia C, Bramanti P, Cuzzocrea S: Immunomodulatory effects of etanercept in an experimental model of spinal cord injury. J Pharmacol Exp Ther 316:1006-1016, 2006.
10. Chaudhari U, Romano P, Mulcahy LD, Dooley LT, Baker DG, Gottlieb AB: Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial. Lancet 357:1842-1847, 2001.
11. Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ: A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. N Engl J Med 337:1029-1035, 1997.
12. Nikolaus S, Raedler A, Kuhbacher T, Sfikas N, Folsch UR, Schreiber S: Mechanisms in failure of infliximab for Crohn's disease. Lancet 356:1475-1479, 2000.
13. Scallon BJ, Moore MA, Trinh H, Knight DM, Ghrayeb J: Chimeric anti-TNF-alpha monoclonal-antibody CA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions. Cytokine 7:251-259, 1995.
14. Lugering A, Schmidt M, Lugering N, Pauels HG, Domschke W, Kucharzik T: Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology 121:1145-1157, 2001.
15. ten Hove T, van Montfrans C, Peppelenbosch MP, van Deventer SJH: Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut 50:206-211, 2002.
16. Mullane KM, Kraemer R, Smith B: Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167, 1985.
17. Hamada Y, Ikata T, Katoh S, Tsuchiya K, Niwa M, Tsutsumishita Y, Fukuzawa K: Roles of nitric oxide in compression injury of rat spinal cord. Free Radic Biol Med 20:1-9, 1996.
18. Shea TB: Technical report. An inexpensive densitometric analysis system using a Macintosh computer and a desktop scanner. Biotechniques 16:1126-1128, 1994.
19. Cuzzocrea S, Riley DP, Caputi AP, Salvemini D: Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev 53:135-159, 2001.
20. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995.
21. Joshi M, Fehlings MG: Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 1. Clip design, behavioral outcomes, and histopathology. J Neurotrauma 19:175-190, 2002.
22. Joshi M, Fehlings MG: Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor recovery. J Neurotrauma 19:191-203, 2002.
23. Streit WJ, Semple-Rowland SL, Hurley SD, Miller RC, Popovich PG, Stokes BT: Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol 152:74-87, 1998.
24. Taoka Y, Okajima K, Uchiba M, Murakami K, Kushimoto S, Johno M, Naruo M, Okabe H, Takatsuki K: Role of neutrophils in spinal cord injury in the rat. Neuroscience 79:1177-1182, 1997.
25. Carlson SL, Parrish ME, Springer JE, Doty K, Dossett L: Acute inflammatory response in spinal cord following impact injury. Exp Neurol 151:77-88, 1998.
26. Tator CH: Update on the pathophysiology and pathology of acute spinal cord injury. Brain Pathol 5:407-413, 1995.
27. Chatham WW, Swaim R, Frohsin H Jr, Heck LW, Miller EJ, Blackburn WD Jr: Degradation of human articular cartilage by neutrophils in synovial fluid. Arthritis Rheum 36:51-58, 1993.
28. Xu W, Chi L, Xu R, Ke Y, Luo C, Cai J, Qiu M, Gozal D, Liu R: Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury. Spinal Cord 43:204-213, 2005.
29. Beattie MS, Hermann GE, Rogers RC, Bresnahan JC: Cell death in models of spinal cord injury. Prog Brain Res 137:37-47, 2002.
30. Beattie MS, Farooqui AA, Bresnahan JC: Review of current evidence for apoptosis after spinal cord injury. J Neurotrauma 17:915-925, 2000.
31. Armstrong RC, Aja TJ, Hoang KD, Gaur S, Bai X, Alnemri ES, Litwack G, Karanewsky DS, Fritz LC, Tomaselli KJ: Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis. J Neurosci 17:553-562, 1997.
32. Muzio M, Salvesen GS, Dixit VM: FLICE induced apoptosis in a cell-free system. J Biol Chem 272:2952-2956, 1997.
33. Hisahara S, Shoji S, Okano H, Miura M: ICE/CED-3 family executes oligodendrocyte apoptosis by tumor necrosis factor. J Neurochem 69:10-20, 1997.
34. Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC: Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374:733-736, 1995.
35. Bar-Peled O, Knudson M, Korsmeyer SJ, Rothstein JD: Motor neuron degeneration is attenuated in Bax-deficient neurons in vitro. J Neurosci Res 55:542-556, 1999.
36. Nesic-Taylor O, Cittelly D, Ye Z, Xu GY, Unabia G, Lee JC, Svrakic NM, Liu XH, Youle RJ, Wood TG, et al.: Exogenous Bcl-xL fusion protein spares neurons after spinal cord injury. J Neurosci Res 79:628-637, 2005.
37. Casha S, Yu WR, Fehlings MG: Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat. Neuroscience 103:203-218, 2001.