-
1
-
-
33845380541
-
The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion
-
Althaus J, Siegelin MD, Dehghani F, Cilenti L, Zervos AS, Rami A. 2007. The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion. Neurochem Int 50:172-180.
-
(2007)
Neurochem Int
, vol.50
, pp. 172-180
-
-
Althaus, J.1
Siegelin, M.D.2
Dehghani, F.3
Cilenti, L.4
Zervos, A.S.5
Rami, A.6
-
2
-
-
0036598992
-
-
Ashkenazi A. 2002. Targeting death and decoy receptors of the tumour necrosis factor superfamily. Nat Rev Cancer 2:420-430. Bannerman DD, Eiting KT, Winn RK, Harlan JM. 2004. Flice-like inhibitory protein (FLIP) protects against apoptosis and suppresses NF-kB activation induced by bacterial lipopolysaccharide. Am J Pathol 165:1423-1431.
-
Ashkenazi A. 2002. Targeting death and decoy receptors of the tumour necrosis factor superfamily. Nat Rev Cancer 2:420-430. Bannerman DD, Eiting KT, Winn RK, Harlan JM. 2004. Flice-like inhibitory protein (FLIP) protects against apoptosis and suppresses NF-kB activation induced by bacterial lipopolysaccharide. Am J Pathol 165:1423-1431.
-
-
-
-
3
-
-
33846612761
-
Inhibition of HtrA2/Omi ameliorates heart dysfuction following ischemia/reperfusion injury in rat heart in vivo
-
Bhuiyan MS, Fukunaga K. 2007. Inhibition of HtrA2/Omi ameliorates heart dysfuction following ischemia/reperfusion injury in rat heart in vivo. Eur J Pharmacol 557:168-177.
-
(2007)
Eur J Pharmacol
, vol.557
, pp. 168-177
-
-
Bhuiyan, M.S.1
Fukunaga, K.2
-
4
-
-
38349094199
-
Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats
-
Bi FF, Xiao B, Hu YQ, Tian FF, Wu ZG, Ding L, Zhou XF. 2008. Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats. Brain Res 1191:30-38
-
(2008)
Brain Res
, vol.1191
, pp. 30-38
-
-
Bi, F.F.1
Xiao, B.2
Hu, Y.Q.3
Tian, F.F.4
Wu, Z.G.5
Ding, L.6
Zhou, X.F.7
-
5
-
-
0030273118
-
Ischemia-induced neuronal apoptosis
-
Cilenti L, Kyriazis GA, Soundarapandian MM, Stratico V, Yerkes A
-
Choi DW. 1996. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6:667-672. Cilenti L, Kyriazis GA, Soundarapandian MM, Stratico V, Yerkes A,
-
(1996)
Curr Opin Neurobiol
, vol.6
, pp. 667-672
-
-
Choi, D.W.1
-
6
-
-
19944427658
-
Omi/ HtrA2 protease mediates cisplatin-induced cell death in renal cells
-
Park KM, Sheridan AM, Alnemri ES, Bonventre JV, Zervos AS. 2005. Omi/ HtrA2 protease mediates cisplatin-induced cell death in renal cells. Am J Physiol Renal Physiol 288:F371-F379.
-
(2005)
Am J Physiol Renal Physiol
, vol.288
-
-
Park, K.M.1
Sheridan, A.M.2
Alnemri, E.S.3
Bonventre, J.V.4
Zervos, A.S.5
-
7
-
-
0037562009
-
Characterization of a novel and specific inhibitor for the pro-apoptotic protease HtrA2/Omi
-
Cilenti L, Lee Y, Hess S, Srinivasula S, Park KM, Junqueira D, Davis H, Bonventre JV, Alnemri ES, Zervos AS. 2003. Characterization of a novel and specific inhibitor for the pro-apoptotic protease HtrA2/Omi. J Biol Chem 278:11489-11494.
-
(2003)
J Biol Chem
, vol.278
, pp. 11489-11494
-
-
Cilenti, L.1
Lee, Y.2
Hess, S.3
Srinivasula, S.4
Park, K.M.5
Junqueira, D.6
Davis, H.7
Bonventre, J.V.8
Alnemri, E.S.9
Zervos, A.S.10
-
8
-
-
18544386724
-
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitors of apoptosis proteincaspase interaction
-
Hegde R, Srinivasula SM, Zhang Z, Wassell R, Cilenti L, DuBois G, Lazebnik Y, Zervos AS, Fernandes-Alnemri T, Alnemri ES. 2002. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitors of apoptosis proteincaspase interaction. J Biol Chem 277:432-438.
-
(2002)
J Biol Chem
, vol.277
, pp. 432-438
-
-
Hegde, R.1
Srinivasula, S.M.2
Zhang, Z.3
Wassell, R.4
Cilenti, L.5
DuBois, G.6
Lazebnik, Y.7
Zervos, A.S.8
Fernandes-Alnemri, T.9
Alnemri, E.S.10
-
9
-
-
0036547417
-
Death and anti-death:tumour resistance to apoptosis
-
Igney FH, Krammer PH. 2002. Death and anti-death:tumour resistance to apoptosis. Nat Rev Cancer 2:277-288.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 277-288
-
-
Igney, F.H.1
Krammer, P.H.2
-
10
-
-
0035209472
-
Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia
-
Jin K, Graham SH, Mao X, Nagayama T, Simon RP, Greenberg DA. 2001. Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia. J Cereb Blood Flow Metab 21:1411-1421.
-
(2001)
J Cereb Blood Flow Metab
, vol.21
, pp. 1411-1421
-
-
Jin, K.1
Graham, S.H.2
Mao, X.3
Nagayama, T.4
Simon, R.P.5
Greenberg, D.A.6
-
11
-
-
0033216124
-
Knockout of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNF-induced apoptosis
-
Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H. 1999. Knockout of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNF-induced apoptosis. J Neurosci 19:8244-8251.
-
(1999)
J Neurosci
, vol.19
, pp. 8244-8251
-
-
Kitsberg, D.1
Formstecher, E.2
Fauquet, M.3
Kubes, M.4
Cordier, J.5
Canton, B.6
Pan, G.7
Rolli, M.8
Glowinski, J.9
Chneiweiss, H.10
-
12
-
-
0035827569
-
Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
-
Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S. 2001. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem 276:20633-20640.
-
(2001)
J Biol Chem
, vol.276
, pp. 20633-20640
-
-
Krueger, A.1
Schmitz, I.2
Baumann, S.3
Krammer, P.H.4
Kirchhoff, S.5
-
13
-
-
0037162768
-
APOPTOSIS:A Cinderella caspase takes center stage
-
Kumar S, Vaux DL. 2002. APOPTOSIS:A Cinderella caspase takes center stage. Science 297:1290-1291.
-
(2002)
Science
, vol.297
, pp. 1290-1291
-
-
Kumar, S.1
Vaux, D.L.2
-
14
-
-
1942521024
-
Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats
-
Lei B, Popp S, Capuano-waters C, Cottrell JE, Kass IS. 2004. Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats. Neuroscience 125:691-701.
-
(2004)
Neuroscience
, vol.125
, pp. 691-701
-
-
Lei, B.1
Popp, S.2
Capuano-waters, C.3
Cottrell, J.E.4
Kass, I.S.5
-
15
-
-
0036263973
-
Structural insights into the proapoptotic function of mitochondrial serine protease HtrA2/Omi
-
Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y. 2002. Structural insights into the proapoptotic function of mitochondrial serine protease HtrA2/Omi. Nat Struct Biol 9: 436-441.
-
(2002)
Nat Struct Biol
, vol.9
, pp. 436-441
-
-
Li, W.1
Srinivasula, S.M.2
Chai, J.3
Li, P.4
Wu, J.W.5
Zhang, Z.6
Alnemri, E.S.7
Shi, Y.8
-
16
-
-
0028905230
-
Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat
-
Li Y, Chopp M, Jiang N, Zaloga C. 1995. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397.
-
(1995)
J Cereb Blood Flow Metab
, vol.15
, pp. 389-397
-
-
Li, Y.1
Chopp, M.2
Jiang, N.3
Zaloga, C.4
-
17
-
-
10044264403
-
Multiple effects of hyperbaric oxygen on the expression of HIF-1 alpha and apoptotic genes in a global ischemia-hypotension rat model
-
Li Y, Zhou C, Calvert JW, Colohan ART, Zhang JH, 2005. Multiple effects of hyperbaric oxygen on the expression of HIF-1 alpha and apoptotic genes in a global ischemia-hypotension rat model. Exp Neurol 191:198-210.
-
(2005)
Exp Neurol
, vol.191
, pp. 198-210
-
-
Li, Y.1
Zhou, C.2
Calvert, J.W.3
Colohan, A.R.T.4
Zhang, J.H.5
-
18
-
-
0024494427
-
Reversible middle cerebral artery occlusion without craniectomy in rats
-
Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Longa EZ, Weinstein PR, Carlson S, Cummins R. 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91.
-
(1989)
Stroke
, vol.20
, pp. 84-91
-
-
Liu, H.R.1
Gao, E.2
Hu, A.3
Tao, L.4
Qu, Y.5
Most, P.6
Koch, W.J.7
Christopher, T.A.8
Longa, E.Z.9
Weinstein, P.R.10
Carlson, S.11
Cummins, R.12
-
19
-
-
19944429185
-
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion
-
Lopez BL, Alnemri ES, Zervos AS, Ma XL. 2005. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation 111:90-96.
-
(2005)
Circulation
, vol.111
, pp. 90-96
-
-
Lopez, B.L.1
Alnemri, E.S.2
Zervos, A.S.3
Ma, X.L.4
-
20
-
-
67651153370
-
-
Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C
-
Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C,
-
-
-
-
21
-
-
0037016707
-
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
-
Downward J. 2002. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J Biol Chem 277:439-444.
-
(2002)
J Biol Chem
, vol.277
, pp. 439-444
-
-
Downward, J.1
-
22
-
-
0034915133
-
Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke
-
Martin-Villalba A, Hahne M, Kleber S, Vogel J, Falk W, Schenkel J, Krammer PH. 2001. Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke. Cell Death Differ 8:679-686.
-
(2001)
Cell Death Differ
, vol.8
, pp. 679-686
-
-
Martin-Villalba, A.1
Hahne, M.2
Kleber, S.3
Vogel, J.4
Falk, W.5
Schenkel, J.6
Krammer, P.H.7
-
23
-
-
0033562658
-
CD95 ligand (FasL/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons
-
Martin-Villalba A, Herr I, Jeremias I, Hahne M, Brandt R, Vogel J, Schenkel J, Herdegen T, Debatin KM. 1999. CD95 ligand (FasL/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons. J Neurosci 19:3809-3817.
-
(1999)
J Neurosci
, vol.19
, pp. 3809-3817
-
-
Martin-Villalba, A.1
Herr, I.2
Jeremias, I.3
Hahne, M.4
Brandt, R.5
Vogel, J.6
Schenkel, J.7
Herdegen, T.8
Debatin, K.M.9
-
24
-
-
33644858948
-
Reduction of Caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70
-
Matsumori Y, Northington FJ, Hong SM, Kayama T, Sheldon RA, vexler ZS, Ferriero DM, Weinstein PR, Liu J. 2006. Reduction of Caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70. Stroke 37:507-512.
-
(2006)
Stroke
, vol.37
, pp. 507-512
-
-
Matsumori, Y.1
Northington, F.J.2
Hong, S.M.3
Kayama, T.4
Sheldon, R.A.5
vexler, Z.S.6
Ferriero, D.M.7
Weinstein, P.R.8
Liu, J.9
-
25
-
-
0030901498
-
Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice
-
Murakami K, Kondo T, Chan PH. 1997. Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice. Brain Res 751:160-164.
-
(1997)
Brain Res
, vol.751
, pp. 160-164
-
-
Murakami, K.1
Kondo, T.2
Chan, P.H.3
-
26
-
-
67651176671
-
-
Nagata S. 1997. Apoptosis by death factor. Cell 88:355-365. Nakka VP, Gusain A, Mehta SL, Raghubir R. 2008. Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol Neurobiol 37:7-38.
-
Nagata S. 1997. Apoptosis by death factor. Cell 88:355-365. Nakka VP, Gusain A, Mehta SL, Raghubir R. 2008. Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol Neurobiol 37:7-38.
-
-
-
-
27
-
-
4344660326
-
Neuroprotective effect of tacrolimus (FK506) on ischemic brain damage following permanent focal cerebral ischemia in the rat
-
Noto T, Ishiye M, Furuich Y, Keida Y, Katsuta K, Moriguchi A, Matsuoka N, Aramori I, Goto T, Yanagihara T. 2004. Neuroprotective effect of tacrolimus (FK506) on ischemic brain damage following permanent focal cerebral ischemia in the rat. Brain Res Mol Brain Res 128:30-38.
-
(2004)
Brain Res Mol Brain Res
, vol.128
, pp. 30-38
-
-
Noto, T.1
Ishiye, M.2
Furuich, Y.3
Keida, Y.4
Katsuta, K.5
Moriguchi, A.6
Matsuoka, N.7
Aramori, I.8
Goto, T.9
Yanagihara, T.10
-
28
-
-
0031915562
-
Transient global forebrain ischemia induces a prolonged expression of the caspase-3 MRNA in rat hippocampal CA1 pyramidal neurons
-
Ni B, Wu X, Su Y, Stephenson D, Smalstig EB, Clemens J, Paul SM. 1998. Transient global forebrain ischemia induces a prolonged expression of the caspase-3 MRNA in rat hippocampal CA1 pyramidal neurons. J Cereb Blood Flow Metab 18:248-256.
-
(1998)
J Cereb Blood Flow Metab
, vol.18
, pp. 248-256
-
-
Ni, B.1
Wu, X.2
Su, Y.3
Stephenson, D.4
Smalstig, E.B.5
Clemens, J.6
Paul, S.M.7
-
29
-
-
0037276437
-
The CD95 (APO-1/Fas) DISC and beyond
-
Peter ME, Krammer PH. 2003. The CD95 (APO-1/Fas) DISC and beyond. Cell Death Differ 10:26-35.
-
(2003)
Cell Death Differ
, vol.10
, pp. 26-35
-
-
Peter, M.E.1
Krammer, P.H.2
-
30
-
-
30344438523
-
-
Sairanen T, Karjalainen-Lindsberg ML, Paetau A, Ijäs P, Lindsberg PJ. 2006. Apoptosis dominant in the periinfarct area of human ischemic stroke-a possible target of antiapoptotic treatments.Brain 129:189-199.
-
Sairanen T, Karjalainen-Lindsberg ML, Paetau A, Ijäs P, Lindsberg PJ. 2006. Apoptosis dominant in the periinfarct area of human ischemic stroke-a possible target of antiapoptotic treatments.Brain 129:189-199.
-
-
-
-
32
-
-
33645210857
-
Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
-
Song JH, Bellail A, Tse MCL, Yong VW, Hao C. 2006. Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. J Neurosci 26:3299-3308.
-
(2006)
J Neurosci
, vol.26
, pp. 3299-3308
-
-
Song, J.H.1
Bellail, A.2
Tse, M.C.L.3
Yong, V.W.4
Hao, C.5
-
33
-
-
0034785591
-
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, including cell death
-
Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R. 2001. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, including cell death. Mol Cell 8:613-621.
-
(2001)
Mol Cell
, vol.8
, pp. 613-621
-
-
Suzuki, Y.1
Imai, Y.2
Nakayama, H.3
Takahashi, K.4
Takio, K.5
Takahashi, R.6
-
34
-
-
34250799663
-
FLIP (L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death
-
Taoufik E, Valable S, Müller GJ, Roberts ML, Divoux D, Tinel A, Voulgari-Kokota A, Tseveleki V, Altruda F, Lassmann H, Petit E, Probert L. 2007. FLIP (L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death. J Neurosci 27:6633-6646.
-
(2007)
J Neurosci
, vol.27
, pp. 6633-6646
-
-
Taoufik, E.1
Valable, S.2
Müller, G.J.3
Roberts, M.L.4
Divoux, D.5
Tinel, A.6
Voulgari-Kokota, A.7
Tseveleki, V.8
Altruda, F.9
Lassmann, H.10
Petit, E.11
Probert, L.12
-
35
-
-
67651151795
-
-
Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P
-
Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P,
-
-
-
-
36
-
-
8744250363
-
Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15
-
Beguinot F. 2004. Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15. J Biol Chem 279:46566-46572.
-
(2004)
J Biol Chem
, vol.279
, pp. 46566-46572
-
-
Beguinot, F.1
-
38
-
-
0037016686
-
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
-
Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL. 2002. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem 277:445-454.
-
(2002)
J Biol Chem
, vol.277
, pp. 445-454
-
-
Verhagen, A.M.1
Silke, J.2
Ekert, P.G.3
Pakusch, M.4
Kaufmann, H.5
Connolly, L.M.6
Day, C.L.7
Tikoo, A.8
Burke, R.9
Wrobel, C.10
Moritz, R.L.11
Simpson, R.J.12
Vaux, D.L.13
-
39
-
-
33749020532
-
Humanin is a novel neuroprotective agent against Stroke
-
Xu XS, Chua CC, Gao JP, Hamdy RC, Chua BHL. 2006. Humanin is a novel neuroprotective agent against Stroke. Stroke 37:2613-2619.
-
(2006)
Stroke
, vol.37
, pp. 2613-2619
-
-
Xu, X.S.1
Chua, C.C.2
Gao, J.P.3
Hamdy, R.C.4
Chua, B.H.L.5
-
40
-
-
0035854549
-
DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats
-
Yao H, Takasawa R, Fukuda K, Shiokawa D, Sadanaga-Akiyoshi F, Ibayashi S, Tanuma S-l, Uchimura H. 2001. DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats. Mol Brain Res 91:112-118
-
(2001)
Mol Brain Res
, vol.91
, pp. 112-118
-
-
Yao, H.1
Takasawa, R.2
Fukuda, K.3
Shiokawa, D.4
Sadanaga-Akiyoshi, F.5
Ibayashi, S.6
Tanuma, S.-L.7
Uchimura, H.8
|