Dehydroepiandrosterone modifies rat fatty acid composition of serum and different adipose tissue depots and lowers serum insulin levels

Journal of Endocrinology

Volumn 201, Issue 1, 2009, Pages 67-74

  de Heredia, Fátima Pérez ^a   Larqué, Elvira ^a   Zamora, Salvador ^a   Garaulet, Marta ^a,b  

^a UNIVERSITY OF MURCIA   (Spain)

^b Ulniversidad de Murcia   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; INSULIN; MONOUNSATURATED FATTY ACID; OMEGA 6 FATTY ACID; PRASTERONE; FATTY ACID;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FEMALE; FOOD INTAKE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID COMPOSITION; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; SUBCUTANEOUS FAT; WHITE ADIPOSE TISSUE; ANIMAL; BLOOD; BLOOD ANALYSIS; BODY COMPOSITION; CHEMISTRY; COMPARATIVE STUDY; DOWN REGULATION; DRUG EFFECT; LIPID METABOLISM; METABOLISM;

ADIPOSE TISSUE; ANIMALS; BLOOD CHEMICAL ANALYSIS; BODY COMPOSITION; DEHYDROEPIANDROSTERONE; DOWN-REGULATION; FATTY ACIDS; FEMALE; INSULIN; LIPID METABOLISM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 67651022164     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0432     Document Type: Article

References (50)

1. Abadie JM, Malcolm GT, Porter JR & Svec F 2001 Dehydroepiandrosterone alters Zucker rat soleus and cardiac muscle lipid profiles. Experimental Biology and Medicine 226 78278-78279.
2. Ailhaud G, Massiera F, Weill P, Legrand P, Alessandri JM & Guesnet P 2006 Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity. Progress in Lipid Research 45 203-236.
3. Aldámiz-Echevarría L, Prieto JA, Andrade F, Elorz J, Sanjurjo P & Rodríguez Soriano J 2007 Arachidonic acid content in adipose tissue is associated with insulin resistance in healthy children. Journal of Pediatric Gastroenterology and Nutrition 44 77-83.
4. Arlt W 2004 Dehydroepiandrosterone and aging. Best Practice and Research. Clinical Endocrinology and Metabolism 18 363-380.
5. Carluccio MA, Massaro M, Scoditti E & De Caterina R 2007 Vasculoprotective potential of olive oil components. Molecular Nutrition & Food Research 51 1225-1234.
6. Chávez JA & Summers SA 2003 Characterizing the effects of saturated fatty acids on insulin signalling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Archives of Biochemistry and Biophysics 419 101-109.
7. Das UN 2005 A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome. Prostaglandins, Leukotrienes and Essential Fatty Acids 72 343-350.
8. Depreter M, Vandesompele J, Espeel M, Speleman F & Roels F 2002 Modulation of the peroxisomal gene expression pattern by dehydroepiandrosterone and vitamin D: therapeutic implications. Journal of Endocrinology 175 779-792.
9. Dimopoulos N, Watson M, Sakamoto K & Hundal HS 2006 Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochemical Journal 399 473-481.
10. Dobrzyn A & Ntambi JM 2005 The role of stearoyl-CoA desaturase in the control of metabolism. Prostaglandins, Leukotrienes and Essential Fatty Acids 73 35-41.
11. Drevon CA 2005 Fatty acids and expression of adipokines. Biochimica et Biophysica Acta 1740 287-292.
12. Ebeling P & Koivisto VA 1994 Physiological importance of dehydroepiandrosterone. Lancet 343 1479-1481.
13. Folch J, Lees M & Stanley GH 1957 A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226 497-509.
14. Garaulet M, Pérez-Llamas F, Pérez-Ayala M, Martínez P, de Medina FS, Tebar FJ & Zamora S 2001 Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. American Journal of Clinical Nutrition 74 585-591.
15. Ghafoorunissa, Ibrahim A & Natarajan S 2005 Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats. Biochimica et Biophysica Acta 1733 67-75.
16. Gil-Campos M, Larqué E, Ramírez-Tortosa MC, Linde J, Villada I, Cañete R & Gil A 2008 Changes in plasma fatty acid composition after intake of a standardised breakfast in prepubertal obese children. British Journal of Nutrition 99 909-917.
17. Gómez FE, Miyazaki M, Kim YC, Marwah P, Lardy HA, Ntmabi JM & Fox BG 2002 Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA. Biochemistry 41 5473-5482.
18. de Heredia FP, Cerezo D, Zamora S & Garaulet M 2007 Effect of dehydroepiandrosterone on protein and fat digestibility, body protein and muscular composition in high-fat-diet-fed old rats. British Journal of Nutrition 97 464-470.
19. Hernández-Morante JJ, Pérez-de-Heredia F, Luján JA, Zamora S & Garaulet M 2008 Role of DHEA-S on body fat distribution: gender- and depot-specific stimulation of adipose tissue lipolysis. Steroids 73 209-215.
20. Imai K, Kudo N, Koyama M, Shirahata A & Kawashima Y 2001 Effects of dehydroepiandrosterone on oleic acid formation in the liver of rats, mice and guinea pigs. Japanese Journal of Pharmacology 86 437-447.
21. Kajita K, Ishizuka T, Mune T, Miura A, Ishiwaza M, Kanoh Y, Kawai Y, Natsume Y & Yasuda K 2003 Dehydroepiandrosterone down-regulates the expression of peroxisome proliferator-activated receptor-γ in adipocytes. Endocrinology 144 253-259.
22. Kawai S, Yahata N, Nishida S, Nagai K & Mizushima Y 1995 Dehydroepiandrosterone inhibits B16 mouse melanoma cell growth by induction of differentiation. Anticancer Research 15 427-431.
23. Kraegen EW, Cooney GJ, Ye J & Thompson AL 2001 Triglycerides, fatty acids and insulin resistance - hyperinsulinemia. Experimental and Clinical Endocrinology and Diabetes 109 S516-S526.
24. Lea-Currie YR, Wen P & McIntosh MK 1998 Dehydroepiandrosterone reduces proliferation and differentiation of 3T3-L1 preadipocytes. Biochemical and Biophysical Research Communications 248 497-504.
25. Liu D & Dillon JS 2004 Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor. Steroids 69 279-289.
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF & Turner RC 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 412-419.
27. Nestler JE, Clore JN & Blackard WG 1992 Dehydroepiandrosterone: the 'missing link' between hyperinsulinemia and atherosclerosis? FASEB Journal 6 3073-3075.
28. Nugent C, Prins JB, Whitehead JP, Wentworth JM, Chatterjee VK & O'Rahilly S 2001 Arachidonic acid stimulates glucose uptake in 3T3-L1 adipocytes by increasing GLUT1 and GLUT4 levels at the plasma membrane. Evidence for involvement of lipoxygenase metabolites and peroxisome proliferator-activated receptor gamma. Journal of Biological Chemistry 276 9149-9157.
29. Paillard F, Catheline D, Duff FL, Bouriel M, Deugnier Y, Pouchard M, Daubert JC & Legrand P 2008 Plasma palmitoleic acid, a product of stearoyl-CoA desaturase activity, is an independent marker of triglyceridemia and abdominal obesity. Nutrition, Metabolism, and Cardiovascular Diseases 18 436-440.
30. Pérez de Heredia F, Larque E, Portillo MP, Canteras M, Zamora S & Garaulet M 2008 Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin. Nutrition 24 1013-1022.
31. Powell DJ, Turban S, Gray A, Hajduch E & Hundal HS 2004 Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochemical Journal 382 619-629.
32. Raclot T, Groscolas R, Langin D & Ferré P 1997 Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. Journal of Lipid Research 38 1963-1972.
33. Ratko TA, Detrisac CJ, Mehta RG, Kelloff GJ & Moon RC 1991 Inhibition of rat mammary gland chemical carcinogenesis by dietary dehydroepiandrosterone or a fluorinated analogue of dehydroepiandrosterone. Cancer Research 51 481-486.
34. Reeves PG, Nielsen FH & Fahey GC Jr 1993 AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Writing Committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition 123 1939-1951.
35. Regelson W, Loria R & Kalimi M 1994 Dehydroepiandrosterone (DHEA) - the 'Mother Steroid.' I. Immunologic action. Annals of the New York Academy of Sciences 719 553-563.
36. Richards RJ, Porter JR & Svec F 2000 Serum leptin, lipids, free fatty acids and fat-pads in long-term dehydroepiandrosterone-treated Zucker rats. Proceedings of the Society for Experimental Biology and Medicine 223 258-262.
37. Riediger ND, Othman R, Fitz E, Pierce GN, Suh M & Moghadasian MH 2008 Low n-6:n-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in mice. European Journal of Nutrition 47 153-160.
38. Russell AP 2004 Lipotoxicity: the obese and endurance-trained paradox. International Journal of Obesity and Related Metabolic Disorders 28 S66-S71.
39. Ryu JW, Kim MS, Kim CH, Song KH, Park JY, Lee JD, Kim JB & Lee KU 2003 DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats. Biochemical and Biophysical Research Communications 303 726-731.
40. Sánchez J, Pérez-Heredia F, Priego T, Portillo MP, Zamora S, Garaulet M & Palou A 2008 Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity. Journal of Nutritional Biochemistry 19 809-818.
41. Saravanan N, Haseeb A, Ehtesham NZ & Ghafoorunissa 2005 Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue. European Journal of Endocrinology 153 159-165.
42. Sjögren P, Sierra-Johnson J, Gertow K, Rosell M, Vessby B, de Faire U, Hamsten A, Hellenius ML & Fisheret RM 2008 Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance. Diabetologia 51 328-335.
43. Steinberg GR 2007 Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance. Cell Cycle 6 888-894.
44. Tagliaferro AR, Ronan AM, Payne J, Meeker LD & Tse S 1995 Increased lipolysis to beta-adrenergic stimulation after dehydroepiandrosterone treatment in rats. American Journal of Physiology 268 1374-1380.
45. Takahashi Y & Ide T 2000 Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat. British Journal of Nutrition 84 175-184.
46. Vessby B, Aro A, Skarfors E, Berglund L, Salminen I & Lithell H 1994 The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters. Diabetes 43 1353-1357.
47. Waxman DJ 1996 Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. Journal of Endocrinology 150 S129-S147.
48. Wilding JP 2001 Leptin and the control of obesity. Current Opinion in Pharmacology 1 656-661.
49. Yanase T, Kukahori M, Taniguchi S, Nishi Y, Sakai Y, Takayanagi R, Haji M & Nawata H 1996 Serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) in Alzheimer's disease and in cerebrovascular dementia. Journal of Endocrinology 43 119-123.
50. Yaqoop P 2002 Monounsaturated fatty acids and immune function. European Journal of Clinical Nutrition 56 S9-S13.