Effects of dehydroepiandrosterone on oleic acid formation in the liver of rats, mice and guinea pigs

Japanese Journal of Pharmacology

Volumn 86, Issue 4, 2001, Pages 437-447

  Imai, K ^a   Kudo, N ^a   Koyama, M ^a   Shirahata, A ^a   Kawashima, Y ^a  

^a JOSAI UNIVERSITY   (Japan)

Author keywords

Dehydroepiandrosterone; Liver; Oleic acid; Palmitoyl CoA chain elongation; Stearoyl coenzyme A (CoA) desaturation

Indexed keywords

ACYL COENZYME A DESATURASE; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; CYTOCHROME B5; CYTOCHROME B5 REDUCTASE; LIPID; OLEIC ACID; PALMITOYL COENZYME A; PHOSPHATIDYLCHOLINE; PRASTERONE; PRASTERONE SULFATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DIET; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; FATTY ACID DESATURATION; FEEDING; GUINEA PIG; LIVER; MALE; MOUSE; NONHUMAN; RAT; STATISTICAL ANALYSIS;

EID: 0034832957     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.86.437     Document Type: Article

References (34)

1. Dehydroepiandrosterone in morbidly obese adolescents: Effects on weight, body composition, lipids, and insulin resistance
2. Dehydroepiandrosterone alters lipid profiles in Zucker rats
3. Dehydroepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbit
4. Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen; The possible role of nitric oxide
5. Amelioration of insulin resistance in diabetes with dehydroepiandrosterone
6. Effects of dehydroepiandrosterone in rats injected with streptozotocin during the neonatal period
7. Dehydroepiandrosterone and dehydroepiandrosterone sulfate: Their relation to cardiovascular disease
8. Relations between fasting serum insulin, glucose, and dihydroepiandrosterone-sulfate concentrations in obese patients with hypertension: Short-term effects of antihypertensive drugs
9. Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation
10. Carcinogenic and anticarcinogenic effects of dehydroepiandrosterone in the liver of male and female rats
11. Increase in hepatic content of oleic acid induced by dehydroepiandrosterone in the rat
12. The effect of two isomeric octadecenoic acids on the lipid metabolism and growth of Novikoff hepatoma cells
13. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes
14. Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals
15. Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase
16. Hypolipidemic effects in monkeys of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase
17. Protein measurement with the Folin phenol reagent
18. Regulation of palmitoyl-CoA chain elongation and linoleoyl-CoA chain elongation in rat liver microsomes and the differential effects of peroxisome proliferators, insulin and thyroid hormone
19. Purification and properties of long-chain acyl-coenzyme-A synthetase from rat liver
20. Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid
21. A rapid method of total lipid extraction and purification
22. A simple method for the assay of eight steroids in small volumes of plasma
23. Measurement of serum levels of dehydroepiandrosterone sulfate: A comparison of radio-immunoassay and enzymatic analysis
24. Fatty acid modification
25. The fatty acid chain elongation system of mammalian endoplasmic reticulum
26. Relationship between desaturation and chain elongation of palmityl-CoA in rat liver microsomes
27. Sex difference in the metabolism of dehydroepiandrosterone sulfate
28. A comparative study of dehydroepiandrosterone and dehydroepiandrosterone sulphate dynamics by the "urinary" and "blood approach" under physiological conditions
29. Sex differences in dehydroepiandrosterone metabolism in the rat: Different plasma levels following ingestion of DHEA-supplemented diet and different metabolite patterns in plasma, bile and urine
30. Studies on the metabolism of DHEA in rats and mice
31. Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cell
32. Regulation of the immune response by dehydroepiandrosterone and its metabolites
33. 3H]DHEA binding in rat liver
34. Specific binding of dehydroepiandrosterone sulfate to rat liver cytosol: A possible association with peroxisomal enzyme induction