Serum leptin, lipids, free fatty acids, and fat pads in long-term dehydroepiandrosterone-treated Zucker rats

Proceedings of the Society for Experimental Biology and Medicine

Volumn 223, Issue 3, 2000, Pages 258-262

  Richards, Robert J ^a   Porter, Johnny R ^a   Svec, Frank ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; LEPTIN; LIPID; PRASTERONE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CORTICOSTERONE BLOOD LEVEL; DIET RESTRICTION; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYPERLIPIDEMIA; HYPERPHAGIA; INSULIN BLOOD LEVEL; MALE; NONHUMAN; OBESITY; RAT; TEST MEAL; WEIGHT REDUCTION;

EID: 0034115786     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.2000.22336.x     Document Type: Article

References (32)

1. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K. Substitution at codon 269 (glutamine - proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 224:597-604, 1996.
2. Hardie LJ, Rayner DV, Holmes S, Trayhurn P. Circulating leptin levels are modulated by fasting, cold exposure, and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun 223:660-665, 1996.
3. Pagano C, Englaro P, Granzotto M, Blum WF, Sagrillo E, Ferretti E, Federspil G, Vettor R. Insulin induces rapid changes of plasma leptin in lean but not in genetically obese (fa/fa) rats. Int J Obes 21:614-618, 1997.
4. Bray GA. The Zucker fatty rat: A review. Fed Proc 36:148-153, 1977.
5. Kasiske BL, O'Donnell MP, Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 19(Suppl I):I110-I115, 1992.
6. Kava R, Greenwood MR, Johnson PR. Zucker (fa/fa) rat. ILAR News 32:4-8, 1990.
7. Meierfrankenfeld B, Abelenda M, Jauker H, Klingenspor M, Kershaw EE, Chua SCJ, Leibel RL, Schmidt I. Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. Am J Physiol 270:E700-E708, 1996.
8. Johnson PR, Stern JS, Horwitz BA, Harris RE, Greene SF. Longevity in obese and lean male and female rats of the Zucker strain: Prevention of hyperphagia. Am J Clin Nutr 66:890-903, 1997.
9. Cleary MP, Zisk JF. Antiobesity effect of two different levels of dehydroepiandrosterone in lean and obese middle-aged female Zucker rats. Int J Obes 10:193-204, 1986.
10. Wang C, Fukuda N, Ontko JA. Studies on the mechanism of hypertriglyceridemia in the genetically obese Zucker rat. J Lipid Res 25:571-579, 1984.
11. Cleary MP, Vasselli JR, Greenwood MR. Development of obesity in Zucker obese (fa/fa) rat in absence of hyperphagia. Am J Physiol 238:E284-E292, 1980.
12. Misra A, Garg A. Leptin, its receptor, and obesity. J Invest Med 44:540-548, 1996.
13. Flier JS. Leptin expression and action: New experimental paradigms. Proc Natl Acad Sci U S A 94:4242-4245, 1997.
14. Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 274:1185-1188, 1996.
15. Ookuma M, Ookuma K, York DA. Effects of leptin on insulin secretion from isolated rat pancreatic islets. Diabetes 47:219-223, 1998.
16. Saladin R, DeVos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995.
17. De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 270:15958-15961, 1995.
18. Slieker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem 271:5301-5304, 1996.
19. Wright BE, Porter JR, Browne ES, Svec F. Antiglucocorticoid action of dehydroepiandrosterone in young obese Zucker rats. Int J Obes 16:579-583, 1992.
20. Cleary MP, Billheimer J, Finan A, Sartin JL, Schwartz AG. Metabolic consequences of dehydroepiandrosterone in lean and obese adult Zucker rats. Horm Metab Res 16(Suppl 1):43-46, 1984.
21. Cleary MP. The antiobesity effect of dehydroepiandrosterone in rats. Proc Soc Exp Biol Med 196:8-16, 1991.
22. Svec F, Hilton CW, Wright B, Browne E, Porter JR. The effect of DHEA given chronically to Zucker rats. Proc Soc Exp Biol Med 209:92-97, 1995.
23. Cleary MP, Shepherd A, Jenks B. Effect of dehydroepiandrosterone on growth in lean and obese Zucker rats. J Nutr 114:1242-1251, 1984.
24. Shepherd A, Cleary MP. Metabolic alterations after dehydroepiandrosterone treatment in Zucker rats. Am J Physiol 246:E123-E128, 1984.
25. Cleary MP, Fox N, Lazin B, Billheimer JT. A comparison of the effects of dehydroepiandrosterone treatment to ad libitum and pair-feeding in the obese Zucker rat. Nutr Res 5:1247-1257, 1985.
26. Guerre-Millo M. Regulation of ob gene and overexpression in obesity. Biomed Pharmacother 51:318-323, 1997.
27. Zhang Y, Olbort M, Schwarzer K, Nuesslein-Hildesheim B, Nicolson M, Murphy E, Kowalski TJ, Schmidt I, Leibel RL. The leptin receptor mediates apparent autocrine regulation of leptin gene expression. Biochem Biophys Res Commun 240:492-495, 1997.
28. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS. Role of leptin in fat regulation. Nature 380:677, 1996.
29. Klein S, Coppack SW, Mohamed-Ali V, Landt M. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45:984-987, 1996.
30. Gansler TS, Muller S, Cleary MP. Chronic administration of dehydroepiandrosterone reduces pancreatic β-cell hyperplasia and hyperinsulinemia in genetically obese Zucker rats. Proc Soc Exp Biol Med 180:155-162, 1985.
31. Bryson JM, Phuyal JL, Proctor DR, Blair SC, Caterson ID, Cooney GJ. Plasma insulin rise precedes rise in ob mRNA expression and plasma leptin in gold thioglucose-obese mice. Am J Physiol 276:E358-E364, 1999.
32. Swierczynski J, Bannasch P, Mayer D. Increase of lipid peroxidation in rat liver microsomes by dehydroepiandrosterone feeding. Biochem Biophys Acta 1315:193-198, 1996.