P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: Relevance to the hepatobiliary disposition of a model opioid peptide

Pharmaceutical Research

Volumn 21, Issue 7, 2004, Pages 1294-1302

  Hoffmaster, Keith A ^a   Turncliff, Ryan Z ^a   LeCluyse, Edward L ^a   Kim, Richard B ^b   Meier, Peter J ^c   Brouwer, Kim L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

biliary excretion; cell culture; drug transport; drug transport models; hepatocytes; P glycoprotein

Indexed keywords

5 CARBOXY 2',7' DICHLOROFLUORESCEIN; 6 CARBOXY 2',7' DICHLOROFLUORESCEIN; DIPEPTIDYL PEPTIDASE IV; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; FLUORESCEIN DERIVATIVE; GLYCOPROTEIN P; MARKER; MULTIDRUG RESISTANCE PROTEIN 2; OPIATE PEPTIDE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 8; ORGANIC ANION TRANSPORTING POLYPEPTIDE C; POLYPEPTIDE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BILIARY EXCRETION; CELL CULTURE; CELL TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORRELATION ANALYSIS; EVALUATION; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; MEASUREMENT; MICROSCOPY; MODEL; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SPECIES COMPARISON; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD26; BILE; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELLS, CULTURED; ENKEPHALIN, D-PENICILLAMINE (2,5)-; FLUORESCENT ANTIBODY TECHNIQUE; HEPATOCYTES; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORTERS; P-GLYCOPROTEIN; RATS; RATS, WISTAR; SPECIES SPECIFICITY;

EID: 3242699783     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000033018.97745.0d     Document Type: Article

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