Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 7, 2009, Pages 612-618

  Lou, Li Xia ^a,b   Geng, Bin ^a,c   Chen, Yu ^c   Yu, Fang ^c   Zhao, Jing ^c   Tang, Chao Shu ^a,c  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Endoplasmic reticulum stress; Iron load; Oxidative stress; Rat

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CASPASE 12; GLUCOSE REGULATED PROTEIN 78; IRON DEXTRAN; LACTATE DEHYDROGENASE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DAMAGE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART INJURY; IRON OVERLOAD; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER INJURY; MALE; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; TISSUE INJURY; UPREGULATION;

ANIMALS; DRUG-INDUCED LIVER INJURY; ENDOPLASMIC RETICULUM; IRON; IRON OVERLOAD; MALE; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PHYSIOLOGICAL;

EID: 67650711767     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05114.x     Document Type: Article

References (44)

1. Sofic E, Riederer P, Heinsen H, Backmann H. Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J. Neural Transm. 1988 74 : 199 205. (Pubitemid 18276713)
2. Weinberg ED. Roles of iron in neoplasia. Promotion, prevention and therapy. Biol. Trace Elem. Res. 1992 34 : 123 40.
3. Snover DC. Hepatitis C, iron, and hemochromatosis gene mutations. A meaningful relationship or simple cohabitation? Am. J. Clin. Pathol. 2000 113 : 475 8.
4. Wood RJ. The iron-heart disease connection: Is it dead or just hiding? Ageing Res. Rev. 2004 3 : 355 67.
5. Palmer C, Menzies SL, Roberts RL, Pavlick G, Connor JR. Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat. J. Neurosci. Res. 1999 56 : 60 71. (Pubitemid 29190617)
6. Mehta SH, Webb RC, Ergul A, Tawfik A, Dorrance AM, Tawak A. Neuroprotection by tempol in a model of iron-induced oxidative stress in acute ischemic stroke. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004 286 : R283 8.
7. Chevion M, Jiang Y, Har-El R, Berenshtein E, Uretzky G, Kitrossky N. Copper and iron are mobilized following myocardial ischemia: Possible predictive criteria for tissue injury. Proc. Natl Acad. Sci. USA 1993 90 : 1102 6.
8. Duffy SJ, Biegelsen ES, Holbrook M et al. Iron chelation improves endothelial function in patients with coronary artery disease. Circulation 2001 103 : 2799 804.
9. Henle ES, Luo Y, Gassmann W, Linn S. Oxidative damage to DNA constituents by iron-mediated Fenton reactions. The deoxyguanosine family. J. Biol. Chem. 1996 271 : 21 177 86.
10. Jacob AK, Hotchkiss RS, Swanson PE, Tinsley KW, Karl IE, Buchman TG. Injection of iron compounds followed by induction of the stress response causes tissue injury and apoptosis. Shock 2000 14 : 460 4.
11. Luo Y, Henle ES, Linn S. Oxidative damage to DNA constituents by iron-mediated Fenton reactions. The deoxycytidine family. J. Biol. Chem. 1996 271 : 21 167 76.
12. 2+ homeostasis in experimental iron overload: A possible factor in cell injury. Biochim. Biophys. Acta 1989 1014 : 133 40.
13. Anghileri LJ. Iron, intracellular calcium ion, lipid peroxidation and carcinogenesis. Anticancer Res. 1995 15 : 1395 400.
14. Paschen W. Mechanisms of neuronal cell death: Diverse roles of calcium in the various subcellular compartments. Cell Calcium 2003 34 : 305 10.
15. Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls. Genes Dev. 1999 13 : 1211 33.
16. Rao RV, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004 11 : 372 80.
17. Lindholm D, Wootz H, Korhonen L. ER stress and neurodegenerative diseases. Cell Death Differ. 2006 13 : 385 92.
18. Ozcan U, Cao Q, Yilmaz E et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004 306 : 457 61.
19. Ma Y, Hendershot LM. The role of the unfolded protein response in tumour development: Friend or foe? Nat. Rev. Cancer 2004 4 : 966 77.
20. Ji C, Kaplowitz N. ER stress: Can the liver cope? J. Hepatol. 2006 45 : 321 33.
21. Lou LX, Geng B, Yu F et al. Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats. Life Sci. 2006 79 : 1856 64.
22. Kaufman RJ. Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 2002 110 : 1389 98.
23. Lieu PT, Heiskala M, Peterson PA, Yang Y. The roles of iron in health and disease. Mol. Aspects Med. 2001 22 : 1 87. (Pubitemid 32143801)
24. Mandalunis PM, Cabrini RL, Ubios AM. Iron overloading inhibits endochondral ossification. Acta Odontol. Latinoam. 1997 10 : 55 61.
25. Puntarulo S. Iron, oxidative stress and human health. Mol. Aspects Med. 2005 26 : 299 312. (Pubitemid 41225354)
26. Morris CM, Candy JM, Oakley AE, Bloxham CA, Edwardson JA. Histochemical distribution of non-haem iron in the human brain. Acta Anat. 1992 144 : 235 57.
27. Focht SJ, Snyder BS, Beard JL, Van Gelder W, Williams LR, Connor JR. Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains. Neuroscience 1997 79 : 255 61.
28. Askawa T, Matashushita S. Thiobarbituric acid test for detecting lipid peroxide. Lipids 1979 14 : 401 6.
29. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976 72 : 248 54.
30. Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes 2002 51 : 2348 54.
31. 2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat. Med. 2003 9 : 1187 94.
32. Bartfay WJ, Hou D, Lehotay DC et al. Cytotoxic aldehyde generation in heart following acute iron-loading. J. Trace Elem. Med. Biol. 2000 14 : 14 20. (Pubitemid 30323941)
33. Tapia G, Troncoso P, Galleano M, Fernandez V, Puntarulo S, Videla LA. Time course study of the influence of acute iron overload on Kupffer cell functioning and hepatotoxicity assessed in the isolated perfused rat liver. Hepatology 1998 27 : 1311 16.
34. Lucesoli F, Caligiuri M, Roberti MF, Perazzo JC, Fraga CG. Dose-dependent increase of oxidative damage in the testes of rats subjected to acute iron overload. Arch. Biochem. Biophys. 1999 372 : 37 43.
35. Limdi JK, Crampton JR. Hereditary haemochromatosis. Q. J. Med. 2004 97 : 315 24.
36. Khan MF, Wu X, Tipnis UR, Ansari GA, Boor PJ. Protein adducts of malondialdehyde and 4-hydroxynonenal in livers of iron loaded rats: Quantitation and localization. Toxicology 2002 173 : 193 201. (Pubitemid 34311855)
37. Sochaski MA, Bartfay WJ, Thorpe SR et al. Lipid peroxidation and protein modification in a mouse model of chronic iron overload. Metabolism 2002 51 : 645 51.
38. Bartfay WJ, Butany J, Lehotay DC et al. Biochemical, histochemical, and electron microscopic study on the effects of iron-loading on the hearts of mice. Cardiovasc. Pathol. 1999 8 : 305 14.
39. Halliday JW, Searle J. Hepatic iron deposition in human disease and animal models. Biometals 1996 9 : 205 9.
40. Hendershot LM. The ER function BiP is a master regulator of ER function. Mt Sinai. J. Med. 2004 71 : 289 97.
41. Rao RV, Hermel E, Castro-Obregon S et al. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J. Biol. Chem. 2001 276 : 33 869 74.
42. Kim R, Emi M, Tanabe K, Murakami S. Role of the unfolded protein response in cell death. Apoptosis 2006 11 : 5 13. (Pubitemid 43151639)
43. Mori K. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 2000 101 : 451 4.
44. Faye A, Ramey G, Foretz M, Vaulont S. Haptoglobin is degraded by iron in C57BL/6 mice: A possible link with endoplasmic reticulum stress. Blood Cells Mol. Dis. 2007 39 : 229 37.