A biochemical, histochemical, and electron microscopic study on the effects of iron-loading on the hearts of mice

Cardiovascular Pathology

Volumn 8, Issue 6, 1999, Pages 305-314

  Bartfay, Wally J ^a   Butany, Jagdish ^a   Lehotay, Denis C ^b   Sole, Michael J ^a   Hou, David ^a   Bartfay, Emma ^c   Liu, Peter P ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; FREE RADICAL; GLUTATHIONE PEROXIDASE; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HEART FAILURE; HEART MUSCLE INJURY; IRON OVERLOAD; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CARDIOMYOPATHIES; FREE RADICALS; GLUTATHIONE PEROXIDASE; HEART; HISTOCYTOCHEMISTRY; IRON; IRON OVERLOAD; IRON-DEXTRAN COMPLEX; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON; MYOCARDIUM; ORGANELLES;

EID: 0032715141     PISSN: 10548807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1054-8807(99)00008-3     Document Type: Article

References (49)

1. Tenenbein M., Kopelow M.L., deSa D.J. Myocardial failure and shock in iron poisoning. Human Toxicol. 7:1988;281-284.
2. Artman M., Olsen R.D., Bancek R.J. Jr., Ghishan F.K., Boieth R.C. Acute effects of iron on contractile function in isolated rabbit myocardium. Dev Pharmacol Ther. 7:1984;50-60.
3. Liu P., Olivieri N. Iron overload cardiomyopathy. new insights into an old disease Cardiovasc Drugs Ther. 8:1994;101-110.
4. McCord J.M. Effects of positive iron status at a cellular level. Nutr Rev. 54:1996;85-88.
5. Herbert V., Shaw S., Jayatilleke E., Stopler-Kasdan T. Most free radial injury is iron mediated. it is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin Stem Cells. 12:1994;289-303.
6. Lesnefsky E.J. Tissue iron overload and mechanisms of iron-catalyzed oxidative injury. Adv Exp Med Biol. 366:1994;129-146.
7. Burkitt M.J., Mason R.P. Direct evidence for in vivo hydroxyl radical generation in experimental iron overload. an ESR spin-trapping investigation Proc Natl Acad Sci USA. 88:1991;8440-8444.
8. Kang J.O., Slivka A., Slater G., Cohen G. In vivo formation of hydroxyl radicals following intragastric administration of ferrous salts in rats. J Inorg Biochem. 35:1989;55-69.
9. Young I.S., Trouton T.G., Torney J.J., McMaster D., Callender M.E., Trimble E.R. Antioxidant status and lipid peroxidation in hereditary haemochromotosis. Free Radical Biol Med. 16:1994;393-397.
10. Livrea M.A., Tesoriere L., Pintaudi A.M.et al. Oxidative stress and antioxidant status in beta-thalassemia major. iron-overload and depletion of lipid-soluble antioxidants Blood. 88:1996;3608-3614.
11. Parkkila S., Niemela O., Britton R.S.et al. Vitamin E decreases hepatic levels of aldehyde-derived peroxidation products in rats with iron-overload. Am J Physiol. 270:1996;G376-G384.
12. Houglum K., Filip M., Witzutum B., Choiker M. Malondialdehyde and 4-hydroxynoneal protein adducts in plasma and liver of rat with iron overload. J Clin Invest. 86:1990;1991-1998.
13. Batist G., Norton J., Katki A.G.et al. Cardiac and red blood cell glutathione peroxidase. results of a prospective randomized trail in patients on total parenteral nutrition Cancer Res. 45:1985;5900-5903.
14. Marklund S.L., Westgate N.G., Lundgren E., Roos G. Copper- and zinc-containing superoxide dismutase, maganese-containing superoxide dismutase, catalase and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res. 42:1982;1955-1961.
15. nd ed.). Ottawa: Bradda Printing Services, 1993:207.
16. Bartfay W.J., Dawood F., Wen W.H.et al. Cardiac function and cytotoxic aldehyde production in a murine model of chronic iron-overload. Cardiovasc Res. in press:1999.
17. Bartfay W.J., Hou D., Brittenham G.M.et al. The synergistic effects of vitamin E and selenium in iron-overloaded mouse hearts. Can J Cardiol. 14:1988;937-941.
18. Liu P., Henkelman R.M., Joshi J.et al. Quantification of tissue iron by nuclear magnetic resonance relaxometry in a novel murine thalassemia cardiac iron overload model. Can J Cardiol. 12:1996;155-164.
19. Brittenham G.M., Farrell D.E., Harris J.W.et al. Magnetic-susceptibility measurements of human iron stores. N Engl J Med. 307:1982;1671-1675.
20. McMaster D., Bell N., Anderson P., Love A.H. Automated measurements of two indicators of human selenium status and applicablity to population study. Clin Chem. 36:1990;211-216.
21. Luo X.P., Yazdanpanah M., Bhooi N., Lehotay D.C. Determination of aldehydes and other lipid peroxidation products in biological samples by gas chromatography-mass spectrometry. Anal Biochem. 228:1995;294-298.
22. Dardick I, Eyden B, Federman M, et al. Handbook of Diagnostic Electron Microscopy for Pathologist-in-Training. Tokyo: Society for Ultrastructual Pathology. Igaku-Shoin Medical Publishers, 1996: 2-1, 2-3.
23. Morris C.M., Candy J.M., Oakley A.E., Boxham C.A., Edwardson J.A. Histochemical distribution of non-haem iron in the human brain. Acta Anatomica. 144:1992;235-257.
24. Sheehan DC, Hrapchak BB. Theory and Practice of Histotechnology (2nd ed.).Toronto: C.V. Mosby Company, 1980: 217-218.
25. Parmley R.T., Spicer S.S., Alvarez C.J. Ultrastructural localization of nonheme cellular iron with ferrocyanide. J Histochem Cytochem. 26:1978;729-741.
26. Esterbauer H. Cytotoxicity and genotoxicity of lipid-peroxidation products. Am J Clin Nutr. 57:1993;779S-786S.
27. Halliwell B., Chirico S. Lipid peroxidation. its mechanism, measurement, and significance Am J Clin Nutr. 57:1993;715S-725S.
28. Pucheu S., Coudray C., Tresallet N., Favier A., de Leiris J. Effect of iron overload in the isolated ischemic and reperfused rat heart. Cardiovasc Drugs Ther. 7:1993;701-711.
29. Kukreja R.C., Hess M.L. The oxygen free radical system. from equations through membrane/protein interactions to cardiovascular injury and protection Cardiovasc Res. 26:1992;641-655.
30. Burton K.P. Evidence of direct toxic effects of free radicals in myocardial ischemia and infarction. Free Radic Biol Med. 4:1988;5-7.
31. Faber N.E., Vercellotti G.M., Jacob H.S., Pieper G.M., Gross G.L. Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart. Circ Res. 63:1988;351-360.
32. Ambrosio G., Zweier J.L., Jacobus W.E., Weisfeldt M.L., Falherty J.T. Improvement of postischemic myocardial dysfunction and metabolism induced by administration of deferoxamine at the time of reflow. the role of iron in the pathogenesis of reperfusion injury Circulation. 76:1987;906-915.
33. Link G., Pinson A., Hersko C. Heart cells in culture. a model of myocardial iron overload and chelation J Lab Clin Med. 106:1985;147-153.
34. Michiels C., Raes M., Toussaint O., Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radic Biol Med. 17:1994;235-248.
35. Byer R.M., Sherman N.A., Wallner J.S., Horwitz L.D. Hydrogen peroxide cytotoxicity in cultured cardiac myocytes is iron dependent. Am J Physiol (Heart Circ Physiol). 35:1994;H121-H127.
36. Starke P.E., Faber J.L. Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide - evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction. J Biol Chem. 260:1985;10099-10104.
37. Storz G., Tartaglia L.A., Ames B.N. Transciptional regulator of oxidative stress-inducible genes. direct activation by oxidation Science. 248:1990;189-194.
38. Olsen L.J., Edwards W.D., McCall J.T., Ilstrup D.M., Gersh B.J. Cardiac iron deposition in idiopathic hemochromatosis. histologic and analytic assessment of 14 hearts from autopsy J Am Coll Cardiol. 10:1987;1239-1243.
39. Hershko C., Link G., Tzahor M., Pinson A. The role of iron and iron chelators inanthracycline cardiotoxicity. Leukemia Lymphoma. 11:1993;207-214.
40. Babcock M., de Silva D., Oaks R.et al. Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin. Science. 278:1997;1709-1712.
41. Lemasters J.J., Nieminen A.L. Mitochondrial oxygen radical formation during reductive and oxidative stress to intact hepatocytes. Biosci Reports. 17:1997;281-291.
42. Marcin-Garcia J., Goldenthal M.J., Ananthakrishnan R.et al. Specific mitochondrial DNA deletion in idiopathic dilated cardiomyopathy. Cardiovasc Res. 31:1996;306-316.
43. Marcin-Garcia J., Ananthakrishnan R., Korson M., Goldenthal M.J., Perez-Atayde A. Cardiac mitochondrial dysfunction in Leigh syndrome. Ped Cardiol. 17:1996;387-389.
44. Ichas F., Jouaville L.S., Mazat J.P. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell. 89:1997;1145-1153.
45. Bernardi P., Petronilli V. The permeability transition pore as a mitochondrial calcium release channel. a critical appraisal J Bioenergetic Biomembranes. 28:1996;131-138.
46. 4 on electrical and mechanical activity of guinea pig papillary muscles. Chung-Kuo-Yas-Li-Hsuesh-Pao. 10:1989;523-525.
47. Kim E., Giri S.N., Pessah I.N. Iron (II) is a modulator of ryanodine-sensitive calcium channels of cardiac muscle sarcoplasmic reticulum. Toxicol Applied Pharmacol. 130:1995;57-66.
48. Kaneko M., Matsumoto Y., Hayashi H., Kobayashi A., Yamazaki N. Oxygen free radicals and calcium homeostasis in the heart. Mol Cell Biochem. 139:1994;91-100.
49. 2+ pump by oxygen free radicals. Am J Physiol. 257:1989;H804-H811.